Alginate in Wound Dressings

Aderibigbe, B. A.; Buyana, Buhle

doi:10.3390/pharmaceutics10020042

Cited by 550 publications

(394 citation statements)

References 75 publications

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“…When applied to a wound, the calcium in the alginate reacts with the sodium salts present in the wound exchanges, forming sodium alginate, which is a hydrophilic gel (Lee and Mooney, 2012). Alginate is a naturally occurring biopolymer that is sourced from brown algae (Phaeophyceae), including Ascophyllum nodosum, Laminaria hyperborea, Laminaria japonica, Macrocystis pyrifera, and Laminaria digitate (Aderibigbe and Buyana, 2018). Soluble sodium alginate gel forms as a result of an active ion exchange of calcium ions for sodium ions at the wound surface, resulting in absorption of fluid at the wound site (Aderibigbe and Buyana, 2018).…”

Section: General Description and Physical Propertiesmentioning

confidence: 99%

“…Alginates are processed to form a number of dressing types that vary in their shape and size. They can be adapted to form wafers, nanofibers and topical formulations (Aderibigbe and Buyana, 2018). Alginate dressings are available as freeze-dried porous sheets or flexible fiber dressings.…”

Section: Forms and Productsmentioning

confidence: 99%

“…They can absorb up to 20 times their weight in fluid, and are easy to remove from the wound . Algisite, Algoderm, Curasorb, Kaltostat, Seasorb Alginate, Suprasorb A, Sorbsan, and Tegaderm Alginate are manufactured as a surface sheet and/or a rope (Aderibigbe and Buyana, 2018).…”

Section: Forms and Productsmentioning

confidence: 99%

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First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician knowledge of dressing properties in wound care. Optimal wound management depends on accurate patient assessment, wound diagnosis, clinicians' knowledge of the wound healing process and properties of wound dressings. We conducted a comprehensive review of the physical properties of wound dressing products, including the advantages and disadvantages, indications and contraindications and effectiveness of first-line interactive/bioactive dressing groups commonly used in clinical practice. These include semipermeable films, foams, hydroactives, alginates, hydrofibers, hydrocolloids, and hydrogels. In making decisions regarding dressing product selection, clinicians need to ensure a holistic assessment of patient and wound etiology, and understand dressing properties when making clinical decisions using wound management guidelines to ensure optimal patient outcomes. This review has highlighted there is lack of high quality evidence and the need for future well designed trials.

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Section: General Description and Physical Propertiesmentioning

confidence: 99%

Section: Forms and Productsmentioning

confidence: 99%

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First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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“…This polysaccharide is biocompatible, relatively inexpensive, and its formulations have high absorption capacities [39]. These characteristics, associated with the fact that alginate forms gels with structural similarity to the extracellular tissue matrices, make alginate an interesting material for wound dressings [75]. Following, examples of healing action of alginate-based formulations in skin wound infection are provided.…”

Section: Alginate-based Formulationsmentioning

confidence: 99%

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

et al. 2019

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Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as Acinetobacter baumannii, Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections. Thus, the treatment of non-healing chronic wounds is a huge challenge for health services worldwide, imposing great socio-economic damage to the affected individuals. This scenario has encouraged the use of natural polymers, such as polysaccharide, in order to develop new formulations (membranes, nanoparticles, hydrogels, scaffolds) to be applied in the treatment of skin infections. In this non-exhaustive review, we discuss the applications of polysaccharide-based formulations in the healing of infected wounds in animal models and clinical trials. The formulations discussed in this review were prepared using alginate, cellulose, chitosan, and hyaluronic acid. In addition to have healing actions per se, these polysaccharide formulations can act as transdermal drug delivery systems, controlling the release of active ingredients (such as antimicrobial and healing agents). The papers show that these polysaccharides-based formulations are efficient in controlling infection and improve the healing, even in chronic infected wounds. These data should positively impact the design of new dressings to treat skin infections.

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“…Furthermore, was well demonstrated that alginate is biocompatible, not toxic and able to reduce bacterial infections [18]. For all these reasons, alginate-based dressings and auto-gelling devices [19] were studied and, in some cases, commercialized [20].…”

Section: Introductionmentioning

confidence: 99%

Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing

et al. 2020

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Standard treatments of chronic skin ulcers based on the direct application of dressings still present several limits with regard to a complete tissue regeneration. Innovative strategies in tissue engineering offer materials that can tune cell behavior and promote growth tissue favoring cell recruitment in the early stages of wound healing. A combination of Alginate (Alg), Sericin (SS) with Platelet Lysate (PL), as a freeze-dried sponge, is proposed to generate a bioactive wound dressing to care skin lesions. Biomembranes at different composition were tested for the release of platelet growth factors, cytotoxicity, protective effects against oxidative stress and cell proliferation induction. The highest level of the growth factors release occurred within 48 h, an optimized time to burst a healing process in vivo; the presence of SS differently modulated the release of the factors by interaction with the proteins composing the biomembranes. Any cytotoxicity was registered, whereas a capability to protect cells against oxidative stress and induce proliferation was observed when PL was included in the biomembrane. In a mouse skin lesion model, the biomembranes with PL promoted the healing process, inducing an accelerated and more pronounced burst of inflammation, formation of granulation tissue and new collagen deposition, leading to a more rapid skin regeneration.

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Alginate in Wound Dressings

Cited by 550 publications

References 75 publications

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing

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