2019
DOI: 10.3390/biom10010063
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Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

Abstract: Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as Acinetobacter baumannii, Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections… Show more

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Cited by 73 publications
(54 citation statements)
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“…During evolution, these organisms acquired the ability to synthesize a wide range of metabolites and biomolecules, many of which have a unique chemical structure that other organisms do not have [10,[53][54][55][56]76,77]. Polysaccharides from marine algae are of particular interest due to the high resistance, biological activity, and availability of these organisms in large numbers [21,59,61,69,74].…”
Section: Polysaccharides From Marine Algae Used In the Development Ofmentioning
confidence: 99%
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“…During evolution, these organisms acquired the ability to synthesize a wide range of metabolites and biomolecules, many of which have a unique chemical structure that other organisms do not have [10,[53][54][55][56]76,77]. Polysaccharides from marine algae are of particular interest due to the high resistance, biological activity, and availability of these organisms in large numbers [21,59,61,69,74].…”
Section: Polysaccharides From Marine Algae Used In the Development Ofmentioning
confidence: 99%
“…It consists of several successive and interrelated phases: coagulation (hemostasis), inflammation, fibroblast proliferation, and tissue remodeling [23,[27][28][29][30] (Figure 1). The initial stage is aimed at preventing excessive blood loss, for which it triggers the hemostatic mechanisms in response to bleeding [19,21,24]. This phase lasts for several minutes and mainly affects the epithelial and endothelial compartments, as well as blood cells.…”
Section: Introductionmentioning
confidence: 99%
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“…After this period, the receptacles were removed from the oven, cooled and weighed. The result was calculated using Equation (1).…”
Section: Fiber Content and Moisture Analysismentioning
confidence: 99%
“…Chronic wounds are severe breaks in the skin barrier that fail to heal in an acceptable time-frame, thus preventing the complete restoration of the tissue's anatomical and functional integrity, increasing the likelihood of infections and apoptosis. Wounds become chronic if they do not pass through all the phases of healing, that include hemostasis, inflammatory, proliferative, and remodeling [1,2]. Chronic wounds are an unsuspecting epidemic that affects a large fraction of the world's population [3].…”
Section: Introductionmentioning
confidence: 99%