Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing

Valentin, Thomas; Landauer, Alexander K.; Morales, Luke C.; DuBois, Eric M.; Shukla, Soham; Liu, Muchun; Valentin, Lauren H. Stephens; Franck, Christian; Chen, Po‐Yen; Wong, Ian Y.

doi:10.1016/j.carbon.2018.11.006

Cited by 48 publications

(25 citation statements)

References 33 publications

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“…Alginate (Alg), a polysaccharide extracted from brown algae, has been applied in various bio-related fields due to its cytocompatibility and attractive physicochemical properties ( Yang et al, 2011 ; Lee and Mooney, 2012 ). Efficient gelation of Alg by simple addition of divalent cations makes it an ideal candidate for 3D bioprinting ( Song et al, 2011 ; Valentin et al, 2019 ). Printed Alg structures have been used to engineer various human tissues such as aortic valve ( Hockaday et al, 2012 ), cardiac tissue ( Gaetani et al, 2012 ), bone tissue ( Wang et al, 2015 ), and blood vessels ( Shi et al, 2015 ; Yeo et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs

Liu

Crook

et al. 2020

Front. Bioeng. Biotechnol.

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Tissue engineering, based on a combination of 3D printing, biomaterials blending and stem cell technology, offers the potential to establish customized, transplantable autologous implants using a patient's own cells. Graphene, as a two-dimensional (2D) version of carbon, has shown great potential for tissue engineering. Here, we describe a novel combination of graphene with 3D printed alginate (Alg)-based scaffolds for human adipose stem cell (ADSC) support and osteogenic induction. Alg printing was enabled through addition of gelatin (Gel) that was removed after printing, and the 3D structure was then coated with graphene oxide (GO). GO was chemically reduced with a biocompatible reductant (ascorbic acid) to provide electrical conductivity and cell affinity sites. The reduced 3D graphene oxide (RGO)/Alg scaffold has good cytocompatibility and can support human ADSC proliferation and osteogenic differentiation. Our finding supports the potential for the printed scaffold's use for in vitro engineering of bone and other tissues using ADSCs and potentially other human stem cells, as well as in vivo regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs

Liu

Crook

et al. 2020

Front. Bioeng. Biotechnol.

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“…This phenolated polyelectrolyte complex was prepared using chitosan and alginate, and this principle can be applied to a wide range of combinations of phenolated cationic and anionic biopolymers indicating the broad applicability of this method. While various 3D printing methods such as ionic crosslinking or photo-crosslinking of alginate and chitosan-based hydrogels have been reported previously, 18,[53][54][55] there are several advantages in using the proposed method, such as high flexibility, toughness, and foldability of the hydrogel due to the in situ microfiber formation and weak physical interaction leading to increase in the energy dissipation. Besides, the PHEC suspension shows tunable concentration-dependent viscoelastic properties from sol to solidlike behaviour due to the rapid physical solidification (Video S1 †) between the microfibers via hydrophobic, electrostatic, and van der Waals interactions.…”

Section: Discussionmentioning

confidence: 99%

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

et al. 2022

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“…The high performance came from the astronomical synergy between the Fe 3+ cations (as the crosslinker) and the GO nanosheets (as the cross‐linking sites and the reinforcer) offering excellent mechanical properties . Also, this cation coordination strategy was applied to many other polymer‐based gel‐like materials including alginate, resorcinol–formaldehyde, poly(acrylamide‐ co ‐acrylic acid), which were incorporated with graphene and its derivatives …”

Section: Coordination‐driven Assembly Based On Graphene and Its Derivmentioning

confidence: 99%

Coordination‐Driven Hierarchical Assembly of Hybrid Nanostructures Based on 2D Materials

Liu

Zhong

Xie

2019

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nanobelts), 2D materials exhibit exceptional physical properties including large theoretical surface area, tunable electronic properties, high optical transparency, and excellent mechanical properties. [2] However, the strong re-stacking tendency of 2D materials caused by van der Waals interaction may result in serious loss of surface area, which inevitably weakens their unique properties. Besides, 2D materials always show intrinsic deficiencies for specific applications, despite the merits mentioned above. As a typical example, TMDs possess high theoretical specific capacities for lithium-ion storage but exhibit unsatisfied cyclability and rate capability in practice, because of their aggregation, low conductivity as well as huge volume expansion during lithium-ion insertion/extraction. [3] One effective way to solve these problems is to construct hybrid nanostructures based on 2D materials. [4][5][6][7][8] Hybrid nanostructures, as a class of composite materials, are composed of two or more nanostructured building blocks. [9,10] Hybrid nanostructures not only can energetically combine the intriguing merits and overwhelm the deficiencies of each building block, but also may generate new functions and properties. [3][4][5][6][7][8][11][12][13] These advantages make hybrid nanostructures based on 2D materials highly promising for practical applications with high performance. [14][15][16][17][18] Regarding the multicomponent composition of hybrid nanostructures, the interfacial interaction between the building blocks lays the foundation for structural and morphological stability, thereby influencing the functions and properties of the resulting hybrid nanostructures. [19][20][21][22] In this sense, the rational design and construction of reliable interfacial interaction for hybrid nanostructures are not only important for achieving improved performance, but also critical for understanding the fundamentals of structureproperty relationship.Generally, there are five types of interfacial interactions, i.e., covalent bond, coordination bond, hydrogen bond, π-π interaction, and electrostatic interaction. [19][20][21][22] Covalent bond and coordination bond are much stronger than the other three in terms of bond energy, so the former two are more favorable for constructing hybrid nanostructures with reliable interfacial interaction. [19] However, most 2D materials are chemically inert, which means the covalent modification is not suitable for them. Alternatively, there are coordination atoms in most of 2D materials and their derivatives, and hence coordination 2D materials have received tremendous scientific and engineering interest due to their remarkable properties and broad-ranging applications such as energy storage and conversion, catalysis, biomedicine, electronics, and so forth. To further enhance their performance and endow them with new functions, 2D materials are proposed to hybridize with other nanostructured building blocks, resulting in hybrid nanostructures with various morphologies and structures. The prop...

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Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing

Cited by 48 publications

References 33 publications

3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs

3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

Coordination‐Driven Hierarchical Assembly of Hybrid Nanostructures Based on 2D Materials

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