Alginate fibres modified with unhydrolysed and hydrolysed chitosans for wound dressings

Knill, Charles J.; Kennedy, J. F.; Mistry, Jamie; Miraftab, Mohsen; Smart, G.; Groocock, M.R.; Williams, H. J.

doi:10.1016/j.carbpol.2003.08.004

Cited by 201 publications

(93 citation statements)

References 8 publications

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“…The ionic interaction between alginate and chitosan was utilized by Tamura et al [9] when preparing chitosan coated calcium alginate fibers, by extruding sodium alginate solution into a coagulation bath containing chitosan. Knill et al [10] improved on the method by first degrading chitosan into low molecular weight oligosaccharide, which can penetrate better into the swollen calcium alginate fibers. The resultant fibers were found to have high absorbency as well as sustained antimicrobial properties Miraftab et al [11].…”

Section: Fiber Productionmentioning

confidence: 99%

Marine Bioactive Fibers: Alginate and Chitosan Fibers-A Critical Review

Qin¹,

Deng²,

Hao³

et al. 2017

JTEFT

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Alginate and chitosan are two marine natural polymers with unique structures and properties. Alginate is a polymeric acid, whilst chitosan is a polymeric amine. Both polymers can be made into fibers through the wet-spinning process. This article reviews the novel properties of alginate and chitosan, and compares the functional performances of the two fibers as novel textile materials. The principal applications of alginate and chitosan fibers are also reviewed.

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Section: Fiber Productionmentioning

confidence: 99%

Marine Bioactive Fibers: Alginate and Chitosan Fibers-A Critical Review

Qin¹,

Deng²,

Hao³

et al. 2017

JTEFT

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“…The activity of the bacteria may be confined and finally the bacteria succumb. 23,24) From this viewpoint, nanocomposites with high content of nano-Cu will release more Cu ions in aqueous solution, leading to an enhanced antibacterial effect.…”

Section: Thermal Stability Of Cu/lldpe Nanocompositesmentioning

confidence: 99%

Preparation and Characterization of a Novel Anticorrosion Material: Cu/LLDPE Nanocomposites

2011

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A novel anticorrosion material, copper/linear low density polyethylene (Cu/LLDPE) nanocomposites, was prepared via melt-blend technique. X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive spectrometer (EDS), salt spray test, thermogravimetric analysis (TG), mechanical properties test and bactericidal properties test were employed to character the resultant nanocomposites. The results of XRD and SEM showed that the nanocomposites were a hybrid of the polymer and the copper nanoparticles, and the copper nanoparticles were distributed uniformly in general. The results of salt spay test showed that nano-Cu in LLDPE could react with permeated oxygen, leading to the improvement of anticorrosion properties of the Cu/LLDPE nanocomposites. The results of mechanical properties test and TG analysis indicated that the presence of a small amount of nano-Cu (no more than 5 mass%) could enhance the mechanical properties and thermal stability of the nanocomposites and excessive nano-Cu would cause performance degradation. The bactericidal properties evaluation showed that the bactericidal ability of the Cu/LLDPE nanocomposites increased with nano-Cu content remarkably.

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“…[24][25][26] Alginate has been used in the food industry because it is generally regarded as safe by the US Food and Drug Administration (GRN 328). In general, alginate can chelate with most of divalent cations to form a rigid structure, 27 and the structure of alginate could be made in many different morphologies such as gel, 28 particle, 29 fiber, 30 bulk, 31 and film. 32 The unique cation-induced gelation properties of alginate enable the encapsulation of any nanomaterials with enhanced loading.…”

Section: Introductionmentioning

confidence: 99%

Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

Liao¹,

Liu²,

Yu³

et al. 2014

IJN

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A new microsphere consisting of inorganic mesoporous silica nanoparticles (MSNs) and organic alginate (denoted as MSN@Alg) was successfully synthesized by air-dynamic atomization and applied to the intracellular drug delivery systems (DDS) of liver cancer cells with sustained release and specific targeting properties. MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provides a large surface area for high drug loading and alginate provides excellent biocompatibility and COOH functionality for specific targeting. Rhodamine 6G was used as a model drug, and the sustained release behavior of the rhodamine 6G-loaded MSN@Alg microspheres can be prolonged up to 20 days. For targeting therapy, the anticancer drug doxorubicin was loaded into MSN@Alg microspheres, and the (lysine)4-tyrosine-arginine-glycine-aspartic acid (K 4 YRGD) peptide was functionalized onto the surface of MSN@Alg for targeting liver cancer cells, hepatocellular carcinoma (HepG2). The results of the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and confocal laser scanning microscopy indicate that the MSN@Alg microspheres were successfully uptaken by HepG2 without apparent cytotoxicity. In addition, the intracellular drug delivery efficiency was greatly enhanced (ie, 3.5-fold) for the arginine-glycine-aspartic acid (RGD)-labeled, doxorubicin-loaded MSN@Alg drug delivery system compared with the non-RGD case. The synthesized MSN@Alg microspheres show great potential as drug vehicles with high biocompatibility, sustained release, and targeting features for future intracellular DDS.

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Alginate fibres modified with unhydrolysed and hydrolysed chitosans for wound dressings

Cited by 201 publications

References 8 publications

Marine Bioactive Fibers: Alginate and Chitosan Fibers-A Critical Review

Marine Bioactive Fibers: Alginate and Chitosan Fibers-A Critical Review

Preparation and Characterization of a Novel Anticorrosion Material: Cu/LLDPE Nanocomposites

Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

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