Alginate–chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: Preparation and characterization

Han, Jing; Zhou, Zhao; Yin, Ruixue; Yang, Dongzhi; Nie, Jun

doi:10.1016/j.ijbiomac.2009.11.004

Cited by 210 publications

(120 citation statements)

References 38 publications

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“…However, alginate-based hydrogels may present unpredictable and uncontrollable degradation and dissolution profiles after loss of the divalent cation cross-linkers [153]. To overcome this issue, covalent/ionic cross-linking can be employed with other biopolymers such as gelatin [154], heparin [155], polyvinyl alcohol [156] and chitosan [157]. The other main disadvantage of alginate-based materials is their inability to undergo efficient and rapid enzymatic degradation in mammals.…”

Section: Cellulose and Its Derivativesmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

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Section: Cellulose and Its Derivativesmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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“…Alginate, a natural resource of polysaccharides derived from seaweed, is widely used in biomedical purposes [17,18]. Recently, alginate-based scaffolds, such as HA/alginate and HA/alginate/chitosan composites, have been developed for bone tissue engineering [19,20]. Particularly, HA/ alginate composite scaffolds have been found to increase the pore size of bone [21,22].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Porous Hydroxyapatite and Alginate Composite Scaffolds for Bone Tissue Engineering

2018

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Objective: To prepare and characterize composite scaffolds of a hydroxyapatite (HA) and an alginate having high viscosity. Materials and Methods:HA powder was synthesized using wet chemical precipitation, the alginate powder was extracted from the Sargassum duplicatum seaweed, and the HA/alginate composite scaffolds were prepared by freeze-drying. X-ray diffraction and Fourier transform infrared techniques were utilized to characterize the HA and alginate, and electron microscopy was used to evaluate the HA and the HA/alginate composite scaffolds. The HA/alginate composite scaffold obtained from the commercially available HA and alginate powders were employed as a comparison.Results: Synthesized HAs were identified as the HA phase, which contained absorbed water, phosphate, and carbonate groups. The extracted alginate contained the carboxyl, cyclic ether and hydroxyl groups. The scaffolds prepared from the HA and alginate mixture were three-dimensional and containing interconnected pores with a diameter ranging from 150 to 300 µm and pore walls of a composite construction. Conclusion:A three-dimensional scaffold was produced using a freeze-drying method from a composite of HA and the high viscosity alginate solution. The scaffold was highly porous and showed interconnected pores, with a diameter ranging from 150 to 300 µm.

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“…These images demonstrate that all polymer and composite blends form macroporous sponge-like materials with irregular interconnected porosity, the density of which increases as a function of chitosan-content. Interconnected macroporosity with pores in the observed range (∼ 20-100 µm) are optimally sized for bone cell ingrowth and the diffusion of nutrients and metabolites [10]. The addition of bioactive glass is seen to increase the density of the sponges and also to reduce the pore size, without diminishing their potential functional capabilities as in situ tissue scaffolds.…”

Section: Optical Microscopy Of the Polymer And Composite Spongesmentioning

confidence: 96%

Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

et al. 2017

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This research concerns the development of solvent-cast lyophilised composite sponges in the bioactive glassalginate-chitosan system for alveolar bone tissue maintenance following tooth extraction. Hydroxyapatite formed on the surfaces of pure alginate, 50:50 alginate:chitosan blend and pure chitosan sponges blended with 10 wt.% bioactive glass within 7 days of exposure to simulated body fluid, indicating that they possess the potential to stimulate bone tissue formation. In the absence of bioactive glass, pure chitosan sponges also demonstrated in vitro bioactivity, to a lesser extent; unlike pure alginate and 50:50 alginate:chitosan blend, which did not. All samples formed macroporous sponges whose biocompatibility with human osteosarcoma cells increased as a function of chitosan-content. Polyelectrolyte complex formation between alginate and chitosan, and the incorporation of bioactive glass were found to increase the swelling capacity of the sponges in SBF. The findings of this study demonstrate that, bioactive glass-chitosan sponges are the favoured candidates for alveolar bone tissue augmentation as their rate of hydroxyapatite formation and biocompatibility are superior to those of the other samples.

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Alginate–chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: Preparation and characterization

Cited by 210 publications

References 38 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Preparation and Characterization of Porous Hydroxyapatite and Alginate Composite Scaffolds for Bone Tissue Engineering

Composite Sponges for in Situ Alveolar Bone Regeneration Following Tooth Extraction

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