Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives

Maity, Chandan; Das, Nikita

doi:10.1007/s41061-021-00360-8

Cited by 42 publications

(30 citation statements)

References 331 publications

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“…Its chemical structure is mainly composed of two different units, namely α-L-guluronic acid and β-D-mannuronic acid, connected by 1,4-glycosidic bonds [ 112 ]. Alginate is an abundant and available biopolymer that displays several interesting features, as it has remarkable biocompatibility, good porosity, great water retention capacity and tunable viscosity, which makes it a material particularly well-suited to biomedical approaches [ 111 , 113 ]. Alginates can form ionic gels due to ion exchange between the monovalent ion in the alginate solution and polyvalent cations [ 112 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Since the alginate polymer plays a major role in the gelling of the hydrogels, increasing the content of G residues in the chains is known to correlate positively with the gelling properties of alginate leading to more strong gels that can be maintained in culture for longer periods . Especially, the G blocks also play an important part in the alginate gel network formation and stabilization …”

Section: Introductionmentioning

confidence: 99%

3D Biofabrication of a Cardiac Tissue Construct for Sustained Longevity and Function

Alonzo

Khoury

Nagiah

et al. 2022

ACS Appl. Mater. Interfaces

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In this study, we developed three-dimensional (3D) printed annular ring-like scaffolds of hydrogel (gelatin–alginate) constructs encapsulated with a mixture of human cardiac AC16 cardiomyocytes (CMs), fibroblasts (CFs), and microvascular endothelial cells (ECs) as cardiac organoid models in preparation for investigating the role of microgravity in cardiovascular disease initiation and development. We studied the mechanical properties of the acellular scaffolds and confirmed their cell compatibility as well as heterocellular coupling for cardiac tissue engineering. Rheological analysis performed on the acellular scaffolds showed the scaffolds to be elastogenic with elastic modulus within the range of a native in vivo heart tissue. The microstructural and physicochemical properties of the scaffolds analyzed through scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy-attenuated total reflectance (ATR-FTIR) confirmed the mechanical and functional stability of the scaffolds for long-term use in in vitro cell culture studies. HL-1 cardiomyocytes bioprinted in these hydrogel scaffolds exhibited contractile functions over a sustained period of culture. Cell mixtures containing CMs, CFs, and ECs encapsulated within the 3D printed hydrogel scaffolds exhibited a significant increase in viability and proliferation over 21 days, as shown by flow cytometry analysis. Moreover, via the expression of specific cardiac biomarkers, cardiac-specific cell functionality was confirmed. Our study depicted the heterocellular cardiac cell interactions, which is extremely important for the maintenance of normal physiology of the cardiac wall in vivo and significantly increased over a period of 21 days in in vitro. This 3D bioprinted “cardiac organoid” model can be adopted to simulate cardiac environments in which cellular crosstalk in diseased pathologies like cardiac atrophy can be studied in vitro and can further be used for drug cytotoxicity screening or underlying disease mechanisms.

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“…In contrast, HB and HD were all fractured at around 19% strains. That was because that PILs could penetrate injectable hydrogels to form a semi-interpenetrate (semi-IPN) network, then the crosslinking density of hydrogels increased [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels

Zhao

Sheng

Zhou

2022

Gels

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Traditional antibacterial hydrogels have a broad-spectrum bactericidal effect and are widely used as wound dressings. However, the biological toxicity and drug resistance of these antibacterial hydrogels cannot meet the requirements of long-term clinical application. Imidazolium poly(ionic liquids) (PILs) are polymeric antibacterial agents exhibiting strong antibacterial properties, as they contain a strong positive charge. In this study, two imidazolium PILs, namely poly(N-butylimidazolium propiolic acid sodium) (PBP) and poly(N-(3,6-dioxaoctane) imidazolium propiolic acid sodium) (PDP), as high efficiency antibacterial agents, were synthesized by polycondensation reaction. Then, the PILs were compounded with polyethylene glycol (PEG) by a thiol-yne click reaction to prepare injectable antibacterial hydrogels. An in vitro assay showed that the injectable antibacterial hydrogels could not only quickly kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), but also had low toxicity for human skin fibroblasts cells (HSFs) and human umbilical vein endothelial cells (HUVECs), respectively. Additionally, the lipopolysaccharide (LPS) inflammation model revealed that the injectable antibacterial hydrogels also had anti-inflammatory effects, which would be advantageous to accelerate wound healing.

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Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives

Cited by 42 publications

References 331 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

3D Biofabrication of a Cardiac Tissue Construct for Sustained Longevity and Function

Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels

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