Alginate-based encapsulation of polyphenols from Clitoria ternatea petal flower extract enhances stability and biological activity under simulated gastrointestinal conditions

Pasukamonset, Porntip; Kwon, Oran; Adisakwattana, Sirichai

doi:10.1016/j.foodhyd.2016.06.039

Cited by 146 publications

(162 citation statements)

References 47 publications

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“…In numerous nations, consumable plants polyphenols have been utilized like efficacious constituent in order to enrichment beverages and foods owing to its capacity into counteracting or hinder the movement of a large assortment of illnesses (Pasukamonset, Kwon, & Adisakwattana, ). In spite of a deficiency in the capability to maintain polyphenols bioavailability and stability, the latest findings refer to their effective role in reducing the hazard of many diseases such diseases related to aging, cancer, and cardiovascular (D'Archivio, Filesi, Varì, Scazzocchio, & Masella, ).…”

Section: Introductionmentioning

confidence: 99%

“…From previous studies, many agents like illumination, pH value, heat, and storage, may significantly influence the stability and efficacy of polyphenols (Arabshahi‐D, Devi, & Urooj, ). For example, exposure of polyphenols to high levels of temperature (more than 180 °C) or heating for a long time cause disintegration and decrement in the antioxidant ability (Pasukamonset et al, ). Their direct application in food processing is restricted because of their repulsive taste and off‐color (Luca, Cilek, Hasirci, Sahin, & Sumnu, ).…”

Section: Introductionmentioning

confidence: 99%

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Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Elsebaie

Essa

2018

J Food Process Preserv

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This work focuses on extraction of biological compounds from red onion peels and its microencapsulation using maltodextrin (MD), soybean protein isolate, and a complex of soybean protein isolate (SPI) and maltodextrin by freeze drying manner. Furthermore, there was a quality evaluation for cake integrated with microencapsulated polyphenols as well as polyphenols stability assessment after baking. Extracts of red onion peel were produced by three methanol concentrations (50, 75, or 100% v/v). A 75% methanolic red onion peel extract (75M) yielded a high total phenolic content, total flavonoid, and antioxidant activity using β‐carotene bleaching and 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging. (SPI + MD) encapsulates had higher encapsulation efficiency (94.30 ± 1.50%). Cake integrated with microcapsules had improved qualitative properties and increased polyphenol content more than other integrated with extract because of encapsulation protective effect pending baking. Comparatively, cake contained SPI microencapsulates showed higher specific volume, moisture absorption, texture, acceptable color, sensory evaluation, and concentration of polyphenols. Practical applications Onion peels are one of the most important onions processing by‐products. The onion peel has a high biological compounds content such as quercetin, phenolics compound, and flavonols. As onion peels extract nature is extremely hygroscopic and sensitive for thermal, it is hard to add them to foodstuffs. The higher polyphenols content of encapsulating incorporated cake were enough to claim for the functionality of polyphenols in the cake. The higher polyphenols content of encapsulating incorporated cake were enough for claiming polyphenols functionality into the cake. (SPI + MD) microcapsules contained high concentrations of red onion peels polyphenols within freeze drying or baking process. Freeze drying is a sufficient technique for add polyphenols into the foodstuffs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Elsebaie

Essa

2018

J Food Process Preserv

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“…In the spectrum B, the bands at 3,413, 1,647, 1,531, and 1,239 cm −1 were assigned to the stretching vibrations of O–H, C=O stretching (amide I), N–H (amide II), and C–H (amide III), respectively, (Teng, Luo, & Wang, ). Compared with the spectra of A and B, the spectrum of C showed some differences: the stretching vibrations of O–H and C=O (amide I) shifted to low wavenumber, from 3,478 and 3,413 cm −1 to 3,294 cm −1 and from 1,649, and 1647 cm −1 to 1643 cm −1 , explained by the presence of intermolecular hydrogen bonds in the nanoparticles (Liu, Wei et al, ); the intensity of the peaks of 1,446 and 1,240 cm −1 arose, and a new peak (1,339) appeared clearly, confirmed by the presence of phenyl–OH structures, which meant that the phenolic compounds were successfully loaded in the nanoparticles (Pasukamonset et al, ; Pawlaczyk‐Graja, ).…”

Section: Resultsmentioning

confidence: 99%

“…the stretching vibrations of O-H and C=O (amide I) shifted to low wavenumber, from 3,478 and 3,413 cm −1 to 3,294 cm −1 and from 1,649, and 1647 cm −1 to 1643 cm −1 , explained by the presence of intermolecular hydrogen bonds in the nanoparticles ; the intensity of the peaks of 1,446 and 1,240 cm −1 arose, and a new peak (1,339) appeared clearly, confirmed by the presence of phenyl-OH structures, which meant that the phenolic compounds were successfully loaded in the nanoparticles (Pasukamonset et al, 2016;Pawlaczyk-Graja, 2018).…”

Section: Morphology Particle Size and Ftir Analysesmentioning

confidence: 91%

“…The FTIR spectra of SA (A), 7S (B), and phenolic compounds-loaded nanoparticles (C) were displayed in Figure 3. The spectrum peaks of A at 3,478, 1,649, 1,416, and 1,029 cm −1 were concerned with the stretching vibrations of O-H, C=O (amide I), COO − (symmetric), and C-O-C, respectively, (Pasukamonset, Kwon, & Adisakwattana, 2016;Stoica, Pop, & Ion, 2013). In the spectrum B, the bands at 3,413, 1,647, 1,531, and 1,239 cm −1 were assigned to the stretching vibrations of O-H, C=O stretching (amide I), N-H (amide II), and C-H (amide III), respectively, (Teng, Luo, & Wang, 2012).…”

Section: Morphology Particle Size and Ftir Analysesmentioning

confidence: 99%

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Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds

Liu

Liao

Wei

et al. 2018

J Food Process Preserv

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Nanoparticles based on sodium alginate (SA) and β‐conglycinin (7S) were self‐assembled according to the electrostatic interaction principle. The self‐assembly parameters optimized by response surface methodology were total concentration of 7S and SA of 6.0 mg/ml, 7S to SA mass ratio of 1.85:1, and pH of 2.5. Phyllanthus urinaria phenolic compounds were loaded into the nanoparticles according to the optimized parameters. The phenolic compounds‐loaded nanoparticles characterized by scanning electron microscopy and particle size analyzer showed that they had a spherical shape with the average size was around 125 nm. Infrared spectroscopy analyses indicated that there were intramolecular hydrogen bonds in the nanoparticles, and the phenolic compounds were successfully encapsulated. The phenolic compounds released from the nanoparticles had good antioxidant activity, and their cumulative release percentage at pH 7.4 was higher than that at pH 1.2. The release kinetics of phenolic compounds showed a pH‐dependent release profile and a Fickian diffusion mechanism. Practical applications Phenolic compounds from Phyllanthus urinaria have excellent bioactivities and have been proven that there are numerous benefits for body. However, the applications of the phenolic compounds are limited because of their chemical instability against environmental conditions. Nanoencapsulation technology is a promising approach to solve this problem. This work aimed at encapsulating the phenolic compounds into nanoparticles by self‐assembly method for the improvement of bioavailability and the applications of food industry.

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The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β₄₂aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease

Khelifi

Tourrette

Dhouafli

et al. 2020

Biotech and App Biochem

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Alzheimer's disease is characterized by amyloid β aggregation and cholinergic neurodegeneration. In the present study, pure DDN (2,3‐dichloro‐5,8‐dihydroxy‐1,4‐naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Aβ42 aggregation. Such investigation was encouraged by the in vitro high antioxidant potential of DDN. Indeed, it revealed interesting antioxidant activity with IC50 values of 9.8 and 4.3 µM for ABTS and reducing power, respectively. The ability of DDN to counteract Aβ42 aggregation was evaluated by thioflavine‐T assay. Strong inhibition of Aβ42 aggregation of more than 90% at 25 µM was measured. Moreover, results showed that DDN inhibited AChE (IC50 = 14.5 µM). To better understand the interactions between DDN and AChE, molecular docking was performed. Obtained data predicted a high interaction characterized by hydrogen bonding at TYR337 as for galanthamine (positive control). Several residues involved in AChE hydrophobic interactions were similarly implicated in binding of this domain to DDN (ASP74, THR83, and TYR124). All these data would be useless if DDN could not pass the blood–brain barrier. So, DDN was loaded into alginate microspheres to enhance its stability and bioavailability. Thereafter, drug release profiles were assessed using immersion cell apparatus.

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Alginate-based encapsulation of polyphenols from Clitoria ternatea petal flower extract enhances stability and biological activity under simulated gastrointestinal conditions

Cited by 146 publications

References 47 publications

Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds

The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β₄₂aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease

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Alginate-based encapsulation of polyphenols from Clitoria ternatea petal flower extract enhances stability and biological activity under simulated gastrointestinal conditions

Cited by 146 publications

References 47 publications

Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Microencapsulation of red onion peel polyphenols fractions by freeze drying technicality and its application in cake

Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds

The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β42aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease

Contact Info

Product

Resources

About

The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β₄₂aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease