Alginate Application for Heart and Cardiovascular Diseases

Xu, Zhengfan; Lam, Mai T.

doi:10.1007/978-981-10-6910-9_7

Cited by 26 publications

(19 citation statements)

References 84 publications

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“…They provide an appropriate niche for cell loading and, in addition, their inherent ionic crosslinking make them injectable which offers advantages over other materials used as solid scaffolds. Alginate polysaccharide has been declared safe, by the United States Food and Drug Administration (FDA) (Xu & Lam, 2018), for application in humans (de Vos, Lazarjani, Poncelet, & Faas, 2014). However, no alginate devices for BTE have been developed so far.…”

Section: Introductionmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

384

209

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This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.

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Section: Introductionmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

384

209

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“…The non-thrombogenic nature of the alginates is one of the most attractive properties and makes it an ideal material for cardiac applications (132,(175)(176)(177). Such applications involve the use of alginate hydrogels and porous 3D scaffolds, and focus on four major areas including: (1) extracellular matrix (ECM) substitute in heart tissues to promote tissue regeneration due the structural similarity between alginate and natural heart ECM, (2) delivery system for cardiac stem cells or adult cardiomyocytes to the injury sites, (3) platform for sustained delivery of growth factors to mimic the natural physiology, and (4) gels to control drug release (178).…”

Section: Alginate-based Biomaterials For Cardiac Tissue Engineeringmentioning

confidence: 99%

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution

Majid

Fricker

Gregory

et al. 2020

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial infarction (MI), arrhythmias, heart failure, heart valve diseases, congenital heart disease, and cardiomyopathy. Cardiac Tissue Engineering (CTE) aims to address these conditions, the overall goal being the efficient regeneration of diseased cardiac tissue using an ideal combination of biomaterials and cells. Various cells have thus far been utilized in pre-clinical studies for CTE. These include adult stem cell populations (mesenchymal stem cells) and pluripotent stem cells (including autologous human induced pluripotent stem cells or allogenic human embryonic stem cells) with the latter undergoing differentiation to form functional cardiac cells. The ideal biomaterial for cardiac tissue engineering needs to have suitable material properties with the ability to support efficient attachment, growth, and differentiation of the cardiac cells, leading to the formation of functional cardiac tissue. In this review, we have focused on the use of biomaterials of natural origin for CTE. Natural biomaterials are generally known to be highly biocompatible and in addition are sustainable in nature. We have focused on those that have been widely explored in CTE and describe the original work and the current state of art. These include fibrinogen (in the context of Engineered Heart Tissue, EHT), collagen, alginate, silk, and Polyhydroxyalkanoates (PHAs). Amongst these, fibrinogen, collagen, alginate, and silk are isolated from natural sources whereas PHAs are produced via bacterial fermentation. Overall, these biomaterials have proven to be highly promising, displaying robust biocompatibility and, when combined with cells, an ability to enhance post-MI cardiac function in pre-clinical models. As such, CTE has great potential for future clinical solutions and hence can lead to a considerable reduction in mortality rates due to CVD.

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“…This showed that alginate and ECM particles in combination could be useful in heart failure (HF) treatment and drug delivery. Injectable alginate hydrogel is also commonly used for replacing damaged ECM [ 147 ]. Through early studies that confirmed the potential of alginate-based hydrogels as ECM substitutes for cell survival promotion in acute MI [ 148 ], newer alginate-based hydrogels were designed to further mimic the cues of the heart’s ECM, where it was observed that alginate can provide tissue support, facilitating myocardial repair and function [ 149 ], as well as aiding in myocardium regeneration after myocardium infarction (MI) ( Figure 12 ) [ 150 ].…”

Section: The Cardiac Ecmmentioning

confidence: 99%

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

et al. 2021

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Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering.

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Alginate Application for Heart and Cardiovascular Diseases

Cited by 26 publications

References 84 publications

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

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