Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González, Aurora C.; Téllez-Jurado, Lucía; Rodríguez‐Lorenzo, Luís M.

doi:10.1016/j.carbpol.2019.115514

Cited by 346 publications

(191 citation statements)

References 203 publications

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“…The rigid, still injectable, hydrogel showed excellent mechanical properties and a nanofibrous architecture similar to the natural fibrillar bone one, guaranteeing excellent in vitro results in terms of cell viability, osteogenic differentiation and cell adhesion to the hydrogel fibres, using MC3T3-E1 cells [100]. Moreover, the alginate hydrogels has been involved as bioink for bioprinting in bone tissue regeneration field [101]. The excellent alginate properties were confirmed by a comparative study of hydrogels in bone tissue engineering that reported the alginate superiority in comparison to hyaluronic acid in bone tissue engineering, reveled by cell viability, proliferation, calcium content, osteocalcin level and osteogenic differentiation [102].…”

Section: Natural Polymersmentioning

confidence: 93%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

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Section: Natural Polymersmentioning

confidence: 93%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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“…Even though alginate has been declared safe for application in humans by the U.S. Food and Drug Administration (FDA) (de Vos et al, 2014;Xu and Lam, 2018), no devices for BTE have been commercialized so far. Interestingly, the use of alginates as bioinks for bioprinting is thought to be a valid opportunity for these hydrogels to expand their application in BTE (Hernández-González et al, 2020).…”

Section: Current Usementioning

confidence: 99%

Natural Polymeric Scaffolds in Bone Regeneration

Filippi

Born

Chaaban

et al. 2020

Front. Bioeng. Biotechnol.

219

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Despite considerable advances in microsurgical techniques over the past decades, bone tissue remains a challenging arena to obtain a satisfying functional and structural restoration after damage. Through the production of substituting materials mimicking the physical and biological properties of the healthy tissue, tissue engineering strategies address an urgent clinical need for therapeutic alternatives to bone autografts. By virtue of their structural versatility, polymers have a predominant role in generating the biodegradable matrices that hold the cells in situ to sustain the growth of new tissue until integration into the transplantation area (i.e., scaffolds). As compared to synthetic ones, polymers of natural origin generally present superior biocompatibility and bioactivity. Their assembly and further engineering give rise to a wide plethora of advanced supporting materials, accounting for systems based on hydrogels or scaffolds with either fibrous or porous architecture. The present review offers an overview of the various types of natural polymers currently adopted in bone tissue engineering, describing their manufacturing techniques and procedures of functionalization with active biomolecules, and listing the advantages and disadvantages in their respective use in order to critically compare their actual applicability potential. Their combination to other classes of materials (such as micro and nanomaterials) and other innovative strategies to reproduce physiological bone microenvironments in a more faithful way are also illustrated. The regeneration outcomes achieved in vitro and in vivo when the scaffolds are enriched with different cell types, as well as the preliminary clinical applications are presented, before the prospects in this research field are finally discussed. The collection of studies herein considered confirms that advances in natural polymer research will be determinant in designing translatable materials for efficient tissue regeneration with forthcoming impact expected in the treatment of bone defects.

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“…CS has also been frequently combined with other polysaccharides, generally anionic, such as ALG or gellan gum (Table 6). Alginate forms readily stable hydrogels in the presence of divalent ions due to the interactions with carboxylic acid groups present on the polymeric chains and the formation of ionic bridges [253,254]. As tear secretion contains divalent ions, notably Ca 2+ ions, ALG, as well as gellan gum and other similar anionic polysaccharides, are good candidates for the preparation of ionically triggered in situ hydrogels.…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Cited by 346 publications

References 203 publications

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Natural Polymeric Scaffolds in Bone Regeneration

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

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