Algebraic modeling of total and regional deposition of inhaled particles in the human lung of various ages

A general, algebraic equation for predicting total respiratory tract deposition of micrometer-sized aerosol particles in humans

“…Therefore, the parameter V t /FRC, where V t is the tidal volume, is here introduced. These three dimensionless, dynamical parameters-Stk * , t * , and V t /FRC-are similar to those described by Yu et al (1992); however, Yu et al (1992) formed an expression for total respiratory tract deposition based instead on dimensional parameters. At present, the ability of the three proposed dimensionless parameters to predict total respiratory tract deposition is investigated.…”

“…In the present communication, we follow an approach similar to that taken by Kim and Hu (2006) and Yu et al (1992), but, in an attempt to extend their results to include a wider range of factors, examine the dependence of total respiratory tract deposition on dimensionless parameters known to influence aerosol deposition in bifurcating airways. Deposition of micrometer-sized particles in healthy adult subjects (Heyder et al, 1986;Kim & Hu, 2006), in children (Schiller-Scotland, Hlawa, Gebhart, Wönne, & Heyder, 1992), in microgravity and hypergravity (Darquenne, Paiva, West, & Prisk, 1997), and in different carrier gases (Darquenne & Prisk, 2004) is considered.…”

“…Nevertheless, some variation between male and female subjects was observed, possibly resulting from differences between average male and female lung volumes, or from other disparities in airway anatomy between genders (Kim & Hu, 2006). A similar algebraic formulation to that of Kim and Hu (2006) was presented by Yu, Zhang, Becquemin, Roy, and Bouchiki (1992), where total deposition efficiency for children and adults was expressed as a function of particle diameter, tidal volume, breathing period, and age in years. Reasonable agreement was reported between predicted and experimentally determined deposition efficiencies averaged over several age groups (Yu et al, 1992).…”

“…A similar algebraic formulation to that of Kim and Hu (2006) was presented by Yu, Zhang, Becquemin, Roy, and Bouchiki (1992), where total deposition efficiency for children and adults was expressed as a function of particle diameter, tidal volume, breathing period, and age in years. Reasonable agreement was reported between predicted and experimentally determined deposition efficiencies averaged over several age groups (Yu et al, 1992).…”

Aerosol Drug Delivery to the Lungs

“…For these reasons, it is desirable to have an idealized mouth -throat model that matches average in vivo deposition data. For adult subjects, one such idealized geometry is the Alberta geometry, as displayed in Figure 7 , which has been shown to match average in vivo include those of Davies [55] , Rudolf et al [38,56] , Yu et al [57] , and the ICRP [3] .…”