The gain characteristics of AlGaN-delta-GaN QWs active region with varying delta-GaN positions and AlGaN compositions are analyzed. From our finding, the use of AlGaN-delta-GaN QW resulted in ~ 7-times increase in material gain, in comparison to that of conventional AlGaN QW, for gain media emitting at 240 nm. By employing asymmetric QW design, with optimized GaN delta layer position and asymmetric AlGaN composition layers, the optimized optical gain can be achievable for AlGaN-delta-GaN QW structure with realistic design applicable for deep and mid UV lasers.