Alendronate enhances osseous healing in a rat calvarial defect model

Toker, Hülya; Özdemir, Hakan; Özer, Hatice; Eren, Kaya

doi:10.1016/j.archoralbio.2012.06.013

Cited by 64 publications

(64 citation statements)

References 28 publications

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“…Finally, this model has some compressive force similar to intraoral conditions (4). In experimental animal studies, the calvarial defect model is considered to be the most exclusive experimental model of bone formation due to poor blood supply and the membranous structure, which preclude any spontaneous healing (5). …”

Section: Discussionmentioning

confidence: 99%

“…The present study used a handmade titanium disc to completely close and protect the calvarial defect area, unlike other studies (5,12). Although there are numerous studies (12,24,25) concerned with the hemostatic effects of ABS, studies associated with the effects of ABS on bone healing are rare and there have been no studies, to the best of our knowledge, using ABS in the OVX rat model.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Ezirganlı

Kazancioğlu

Açar

et al. 2017

Experimental and Therapeutic Medicine

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Bone defects resulting from oncological surgical resections, congenital facial anomalies, trauma or infection represent a significant and common clinical problem. The present study aimed to evaluate the effects of a commercially-available medicinal plant extract product, Ankaferd BloodStopper (ABS), on bone healing. The present study was performed on 24 female ovariectomized (OVX) rats. A defect on each rat calvarium was created using a trephine burr prior to the rats being divided into two groups. Defects were grafted with a gelatin sponge soaked with normal saline (control group) or plant extract (experimental group). Half of the animals were sacrificed after 2 weeks and the others after 4 weeks. In the control group, the defects were not filled with regenerated bone. By contrast, in the experimental group, all defect areas had an increased amount of regenerated bone and connective tissue. Osteoblastic activity appeared to be greater in the experimental group however, osteoclastic activity was observed to be higher in the control group. At 2 and 4 weeks, there was a significant difference in the amount of newly regenerated bone observed in the experimental group compared with the control group (P<0.05). Therefore, the results of the present study indicated that local ABS application had a positive effect on bone healing in the OVX rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Ezirganlı

Kazancioğlu

Açar

et al. 2017

Experimental and Therapeutic Medicine

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“…In vitro studies demonstrated that low-dose ALN was effective in inhibiting osteoclastic activity with no cytotoxic effects 20 , as well as effect on regulatory genes of osteoblasts differentiation 2,10,14 Therefore, some studies have been conducted to evaluate the efficacy of ALN in the treatment of bone and periodontal disorders 26-28,33 . Animal studies have evaluated the effects of both the topical 6,10,16 and systemic 15,17,32 use of ALN in the treatment of intrabuccal bone defects resulting from periodontitis. In humans, clinical trials have investigated the effects of the topical application of ALN on periodontal bone defects treated with surgical 27 or non-surgical procedures 17,26,28,29 .…”

Section: Introductionmentioning

confidence: 99%

Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

Dutra

Oliveira

et al. 2017

J. Appl. Oral Sci.

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Background and objectives Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT).Material and Methods Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05).Results Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment.Conclusions Topical application of 1% ALN might be a beneficial adjuvant to non-surgical periodontal therapy.

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“…The differences in the microstructures, textural properties, in vitro apatite-forming ability, as well as the drug storage/ release properties of the MBGMs obtained with or without alkaline catalyst were investigated. The alendronate (AL), a kind of bisphosphonates, widely used for the treatment of osteoporosis, was chosen as the model drug because of its ability to promote osteoblast growth [14,15], differentiation and osseous healing [16]. Then, the W/O emulsion were prepared by mixing the pre-hydrolysis BG solution as the water phase and liquid paraffin as the oil phase.…”

Section: Introductionmentioning

confidence: 99%

Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery

Miao

Chen

Dong

et al. 2013

Materials Science and Engineering: C

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Alendronate enhances osseous healing in a rat calvarial defect model

Cited by 64 publications

References 28 publications

Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Effects of Ankaferd BloodStopper on bone healing in an ovariectomized osteoporotic rat model

Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery

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