Alendronate alleviates the symptoms of experimental autoimmune encephalomyelitis

Jung, Kyungsook; Kim, Jeong-Tae; Ahn, Ginnae; Matsuda, Hiroshi; Akane, Tanaka; Ahn, Meejung; Shin, Taekyun

doi:10.1016/j.intimp.2020.106534

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…The improvement in Alzheimer' s disease in response to alendronate has been shown to result from a significant decrease in Aβ1-42 and β-site amyloid precursor protein cleaving enzyme-1, a key marker of Alzheimer' s disease [28]. In neurodegenerative disease, such as experimental Yuna Choi and Taekyun Shin autoimmune encephalomyelitis, alendronate mitigates hind-limb paralysis, suppresses T cell proliferation, and limits the inflammatory response [17]. The treatment with alendronate, as an antiinflammatory molecule, is more effective to diminish the SCIinduced secondary degeneration rather than the pre-treatment of alendronate for preventive effect.…”

Section: Discussionmentioning

confidence: 99%

“…Some recent clinical trials suggested that alendronate relieves pain, non-steroidal anti-inflammatory drug resistance, and stiffness, and improves the movement of affected joints [ 16 ]. The anti-inflammatory effect of alendronate, demonstrated in experimental autoimmune encephalomyelitis, an animal model of human multiple sclerosis, occurs through a decrease in infiltration of inflammatory cells and pro-inflammatory cytokines, including IL-1β, TNF-α, and interferon-gamma [ 17 ]. The serine protease inhibitor, clade A, member 3N (sepina3n) is highly found in brain, testis and spleen [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Alendronate Enhances Functional Recovery after Spinal Cord Injury

Choi

Shin

2022

Exp Neurobiol

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Spinal cord injury is a destructive disease characterized by motor/sensory dysfunction and severe inflammation. Alendronate is an anti-inflammatory molecule and may therefore be of benefit in the treatment of the inflammation associated with spinal cord injury. This study aimed to evaluate whether alendronate attenuates motor/sensory dysfunction and the inflammatory response in a thoracic spinal cord clip injury model. Alendronate was intraperitoneally administered at 1 mg/kg/day or 5 mg/kg/day from day (D) 0 to 28 post-injury (PI). The histopathological evaluation showed an alleviation of the inflammatory response, including the infiltration of inflammatory cells, and a decrease in gliosis. Alendronate also led to reductions in the levels of inflammation-related molecules, including mitogen-activated protein kinase, p53, pro-inflammatory cytokines, and pro-inflammatory mediators. Neuro-behavioral assessments, including the Basso, Beattie, and Bresnahan scale for locomotor function, the von Frey filament test, the hot plate test, and the cold stimulation test for sensory function, and the horizontal ladder test for sensorimotor function improved significantly in the alendronate-treated group at D28PI. Taken together, these results suggest that alendronate treatment can inhibit the inflammatory response in spinal cord injury thus improving functional responses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alendronate Enhances Functional Recovery after Spinal Cord Injury

Choi

Shin

2022

Exp Neurobiol

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“…In turn, this leads to the suppression of various inflammatory mediators such as IFN-γ, TNF-α, and inducible nitric oxide synthase. 131…”

Section: Biphosphonatesmentioning

confidence: 99%

“…Alendronate and nitrogen‐containing bisphosphonates substantially reduce the inflammatory cascade in the spinal cord after induction of experimental autoimmune encephalomyelitis, thereby suppressing the proximal assembly of CD68‐positive inflammatory cells. In turn, this leads to the suppression of various inflammatory mediators such as IFN‐γ, TNF‐α, and inducible nitric oxide synthase 131 …”

Section: Mevalonate Pathway and Autoimmune Diseasesmentioning

confidence: 99%

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Kang

Liu

Haneef

et al. 2022

Rheumatology & Autoimmunity

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All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage-associated molecular patterns (DAMPs). In addition to well-characterized DAMPs such as high-mobility group box 1 and adenosine triphosphate, studies on new classes of DAMPs have emerged. Here, we review recent reports of a new class of isoprenoid-derived DAMPs, including farnesyl pyrophosphate and geranylgeranyl pyrophosphate, both of which are pivotal metabolic intermediates of the mevalonate pathway. We also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated inflammation. The findings highlight that understanding the functional mechanisms of DAMPs is important to enrich the DAMP family and decipher their immunoregulatory mechanisms to provide new therapeutics for the prevention and treatment of autoimmune diseases.

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“…In this strategy, the use of BGNCu (amount of copper was doped into BGN) was to take advantage of its antibacterial [ 30 – 32 ] and anti-inflammatory [ 32 – 35 ] properties. By further introducing alendronate sodium with anti-inflammatory [ 36 , 37 ] and antibacterial [ 38 ] properties to increase the performance of the hydrogel. The use of F127-CHO can form a gel network and have a temperature responsive sol-gel conversion ability [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional antibacterial bioactive nanoglass hydrogel for normal and MRSA infected wound repair

et al. 2023

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Large-scale skin damage brings potential risk to patients, such as imbalance of skin homeostasis, inflammation, fluid loss and bacterial infection. Moreover, multidrug resistant bacteria (MDRB) infection is still a great challenge for skin damage repair. Herein, we developed an injectable self-healing bioactive nanoglass hydrogel (FABA) with robust antibacterial and anti-inflammatory ability for normal and Methicillin-resistant Staphylococcus aureus (MRSA) infected skin wound repair. FABA hydrogel was fabricated facilely by the self-crosslinking of F127-CHO (FA) and alendronate sodium (AL)-decorated Si-Ca-Cu nanoglass (BA). FABA hydrogel could significantly inhibit the growth of Staphylococcus aureus, Escherichia coli and MRSA in vitro, while showing good cytocompatibility and hemocompatibility. In addition, FABA hydrogel could inhibit the expression of proinflammatory factor TNF-α and enhance the expression of anti-inflammatory factor IL-4/ IL-10. Based on its versatility, FABA hydrogel could complete wound closure efficiently (75% at day 3 for normal wound, 70% at day 3 for MRSA wound), which was almost 3 times higher than control wound, which was related with the decrease of inflammatory factor in early wound. This work suggested that FABA hydrogel could be a promising dressing for acute and MRSA-infected wound repair. Graphical Abstract

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Alendronate alleviates the symptoms of experimental autoimmune encephalomyelitis

Cited by 10 publications

References 21 publications

Alendronate Enhances Functional Recovery after Spinal Cord Injury

Alendronate Enhances Functional Recovery after Spinal Cord Injury

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Multifunctional antibacterial bioactive nanoglass hydrogel for normal and MRSA infected wound repair

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