Aldosterone Secretion and Metabolism in Normal Men and Women and in Pregnancy

Jones, K. M.; Lloyd-Jones, R.; Riondel, A. M.; Tait, John; Tait, S. A. S.; Bulbrook, R. D.; Greenwood, F. C.

doi:10.1530/acta.0.0300321

Cited by 114 publications

(42 citation statements)

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“…Newton and associates (21) suggested that the generation of increased amounts of angiotensin II by plasma from patients receiving estrogens was due to the increase in the renin substrate concentration in plasma. It is possible that similar changes occur during pregnancy and lead to generation of an increased amount of angiotensin II as reported by Newton et al (21) (22) found an increase in the daily rate of aldosterone production in only three of the six pregnant women on a normal uncontrolled diet. In the most extensive study, Watanabe, Meeker, Gray, Sims, and Solomon (8), measured aldosterone secretion in 57 normal pregnant women 23-32 yr of age; dietary sodium intake was estimated to range from 80 to 190 mEq/day.…”

Section: Introductionsupporting

confidence: 56%

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Mechanisms regulating the renal excretion of sodium during pregnancy

Robb¹,

Davis²,

Johnson³

et al. 1970

J. Clin. Invest.

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A B S T R A C T Observations were made on the relation of the renin-angiotensin-aldosterone system and renal hemodynamic function to sodium balance in 43 pregnant dogs. Daily balance studies revealed that about 30-40% of ingested sodium was retained during the last half of pregnancy; during the same period, potassium balance was also positive but to a lesser extent. For groups of pregnant dogs, plasma renin activity (n = 14) and aldosterone secretion (n = 19) were significantly higher than normal; however, in some animals one or both functions were normal even though sodium retention was present. In contrast, plasma renin substrate concentration was consistently elevated during pregnancy in seven dogs. In a group of nine dogs in which both aldosterone secretion and plasma renin activity were measured, aldosterone secretion was elevated in the three dogs with the highest values for plasma renin activity; in two of the remaining six animals aldosterone secretion was elevated but plasma renin activity was normal or only slightly increased. The sequestration of sodium and water into the uterine contents was defined quantitatively in this study but evidence was lacking to support the idea that such changes led to renin release. The glomerular filtration rate (GFR) was significantly elevated throughout pregnancy but a significant decrease from the high level of mid-pregnancy occurred during the last half of pregnancy; this decrease in GFR probably contributed to the sodium retention. Administration of a large dose of deoxycorticosterone acetate (DOCA) to dogs in late pregnancy produced marked sodium retention but "escape" from the sodium-retaining steroid occurred. The data demonstrate that although increased activity of the renin-angiotensin-aldosterone system was frequently present during pregnancy, a normal rate of aldosterone secretion occurred. This finding and the observed "es-

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Section: Introductionsupporting

confidence: 56%

“…The results revealed a high rate of aldosterone secretion during the 3rd trimester of pregnancy in nearly all the women. The rate of aldosterone metabolism has been reported (22) to be normal in pregnancy, so increased secretion of the hormone appears to be the only mechanism leading to hyperaldosteronemia in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms regulating the renal excretion of sodium during pregnancy

Robb¹,

Davis²,

Johnson³

et al. 1970

J. Clin. Invest.

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show abstract

“…High urinary excretion of aldosterone was assumed to reflect an increased secretion of aldosterone by the adrenal gland, but the findings of Jones and associates (9) suggested that this high urinary excretion may not reflect a proportionate increased secretion of the hormone. Although Jones and associates noted increased aldosterone secretion in half of the pregnant subjects in their study, they postulated that the increased urinary excretion of aldosterone in pregnancy was due in part to an alteration in the metabolism of the hormone from that in normal nonpregnant subjects.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, it has been shown that the high blood levels of hydrocortisone in pregnancy could be accounted for by the increased binding of this hormone to blood proteins (8). It has been reported that aldosterone is secreted in increased amounts during pregnancy (9,10). From available evidence, it has been concluded that in humans aldosterone is not a secretory product of the placenta (11)(12)(13)(14), but that it is formed in the adrenal gland.…”

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confidence: 99%

“…Jones and associates (9), using an isotope dilution method for aldosterone developed by Ayres and associates (26), studied six pregnant subjects in the third trimester and found that three had elevated levels, whereas the others were within the range for normal nonpregnant females. In a preliminary study by Van de Weile and associates (10), aldosterone secretion rates were found to be elevated in all three normal pregnant subjects studied.…”

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