Aldosterone and Angiotensin

Davis, James O.

doi:10.1001/jama.1964.03060380030008

Cited by 14 publications

(3 citation statements)

References 31 publications

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“…Relation of renin and aldosterone in pregnancy Considerable evidence (see review by Davis, 1964) supports Gross's (1958) suggestion that the renin-angiotensin system may regulate sodium balance by an effect on aldosterone secretion. The present findings lend some support to this view in that both the secretion (Jones, Lloyd Jones, Riondel, Tait, Tait, Bulbrook & Greenwood, 1959;Gray, Munro, Sims, Meeker, Solomon & Watanabe, 1964; and excretion (Martin & Mills, 1956;Venning & Dyrenfurth, 1956;Rinsler & Rigby, 1957) of aldosterone are also known to increase during pregnancy.…”

Section: Source Of Renin In Maternal Plasmamentioning

confidence: 98%

Serial Estimation of Plasma Renin Concentration During Pregnancy and After Parturition

Brown¹,

Davies²,

Doak³

et al. 1966

Journal of Endocrinology

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Section: Source Of Renin In Maternal Plasmamentioning

confidence: 98%

Serial Estimation of Plasma Renin Concentration During Pregnancy and After Parturition

Brown¹,

Davies²,

Doak³

et al. 1966

Journal of Endocrinology

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“…In addition, isotocin and vasotocin and extracts of the urophysis cause diuresis (unpublished results) and these factors could predominate in the absence of the corpuscles. The picture may be further complicated if corpuscular secretion is involved in the rate of corticosteroidogenesis by the adrenal cortex, on analogy with the situation in some mammals (Davis, 1964;Dentón, 1964). Such a consideration would account, at least in part, for the shift of water into cells to give similar patterns in the adrenalectomized eel and in the eel with the corpuscles removed.…”

Section: Controlsmentioning

confidence: 99%

Studies on the Experimental Alteration of Water and Electrolyte Composition of the Eel (Anguilla Anguilla L.)

Chan¹,

Jones²,

Henderson³

et al. 1967

Journal of Endocrinology

121

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The distribution of water, electrolyte composition (Na, K, Ca, Mg, PO4, Cl) and extracellular fluid volume of eels (Anguilla anguilla L.) were investigated under different experimental conditions. Adrenalectomy of the freshwater eel was followed by an increase in body weight, a fall in the amount and concentration of sodium in serum and muscle and a shift of water into the cells. The concentration of serum potassium remained within the normal range. Adrenalectomy of the sea-water eel was followed by a decrease in body weight and an increase in the concentration of extra-and intracellular sodium. The concentration of serum calcium also increased, that of potassium remained within the normal range but the actual content diminished.Removal of the corpuscles of Stannius from the freshwater eel gave some effects similar to adrenalectomy. There was, however, no significant increase in body weight but the concentrations of serum potassium and calcium rose. Removal of the corpuscles from the sea-water eel brought about changes similar to, but less pronounced than those after adrenalectomy. The results of the injection of mammalian corticotrophin, cortisol, aldosterone and anti-aldosterone compounds are given. They are discussed in the light of the possible roles of the adrenal cortex and the corpuscles of Stannius in the maintenance of homeostasis of the eel in different environments.

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“…The large body of evidence showing that the aldosterone-stimulating hormone arises from the kidney and is renin has recently been summarized by Davis. 4 Measurements show an elevated peripheral plasma level of renin in normal human subjects on a low sodium intake 5 " 7 or depleted of sodium. 7 Goormaghtigh's hypothesis 8 that juxtaglomerular (JG) cells secrete renin has recently been strengthened by: correlations between renin content and degree of granulation of JG cells under different experimental conditions in rats, 9 ' 10 microdissection studies, 11 and application of the fluorescent antibody technique.…”

mentioning

confidence: 99%

Renal Vein Renin and Juxtaglomerular Activity in Sodium-Depleted Subjects

Ajzen

Simmons

Woods

1965

Circulation Research

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Ten patients requiring surgery for renal cysts or calculi and having no evidence of secondary hyperaldosteronism were divided, as volunteers for special study, into experimental and control groups. After base line studies, the experimental group was given a diet containing 87 mEq of sodium and 1.0 g of chlorothiazide daily for ten days. Control subjects ate a normal diet. At operation, samples of peripheral and renal venous blood were obtained for measurement of renin activity and renal biopsy was taken for determination of the juxtaglomerular index. Increased renin in renal venous plasma and hypergranularity of the juxtaglomerular apparatus were found in sodium-depleted subjects but not in control subjects. These findings confirm results previously found in animals.

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Aldosterone and Angiotensin

Cited by 14 publications

References 31 publications

Serial Estimation of Plasma Renin Concentration During Pregnancy and After Parturition

Serial Estimation of Plasma Renin Concentration During Pregnancy and After Parturition

Studies on the Experimental Alteration of Water and Electrolyte Composition of the Eel (Anguilla Anguilla L.)

Renal Vein Renin and Juxtaglomerular Activity in Sodium-Depleted Subjects

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