Aldosteron-Antagonisten

Aldosterone and Renal Potassium Excretion

“…These approximations were made from the following reported data. Men, high sodium intake, 50-60 ugj day, low sodium intake 700-1,300 //g/day [13], Additional rates for men are summarized by Herken [38]. Dogs, normal (hypophysectomized) 1-5 ng/min, elevated plasma potassium, 20-50 ng/ min, (18); normal 0-0.05 //g/min; chronic thoracic inferior vena cava constriction 0.05-0.25 //g/min; heart failure (pulmonary stenosis) 0.5-1.5 //g/min [17].…”

Effects of an Aldosterone Antagonist, Spironolactone, on Pinealectomized Rats

“…No significant differences in this ratio were seen in the arterial wall. Angiotensin, aldosterone and spironolactone, all can affect tissue electrolytes [7,13,17]. The combined effect of these factors might have induced the elevation of tissue sodium concentrations.…”

“…Thus it has been suggested that there might exist a feedback mechanism, so that high blood levels of aldosterone or deoxycorticosterone modify the synthesis and storage of a pineal hormone, which then would have the zona glomerulosa as a target organ [2], These theories, however, have not been uniformly accepted and suggestions to the opposite have also been presented [7],…”