Aldose reductase inhibitors from the leaves of Myrciaria dubia (H. B. & K.) McVaugh

Inhibitory Constituents of Aldose Reductase in the Fruiting Body of Phellinus linteus

“…The structures of these compounds were elucidated based on 1-dimensional ( 1 H-and 13 C-NMR) and 2-dimensional NMR (HMQC and HMBC) spectral data and by comparison with published spectral data. [16][17][18][19][25][26][27][28][29][30][31][32] They were identified as protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), ellagic acid (4), hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11). The chemical structures of compounds 1-11 isolated from the fruiting body of P. linteus are shown in Fig.…”

Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum

“…It has been acknowledged that plant-derived extracts and phytochemicals are potential alternatives to synthetic inhibitors against AR. 19,23,27) Currently, the compounds isolated from plants as AR inhibitors are classified as flavonoids, [19][20][21][22][23][24][25][26] stilbenes, 19) terpenoids, 21) ellagic acid and its derivatives, 28) and alkaloids. The present study was carried out in a search for new potential AR inhibitors from the fruiting bodies of G. applanatum, and cerebrosides (3), 2,5-dihydroxybenzoic acid (6) and protocatechualdehyde (7) were isolated as active principles which may be useful for the treatment of diabetic complications.…”

Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants

“…There are many reports of AR inhibiting activity of natural products such as Eugenia borinquensis, Mangifera indica, Eucalyptus deglupta, and Syzygium malaccense (Guzman and Guerrero, 2005). Ellagic acid and two of its derivatives were found as a potent aldose reductase inhibitors in the leaves of Myrciaria dubia (Ueda et al, 2004). Three flavonoids isolated from Brickellia arguta showed anticataract activity in rats (Rosler et al, 1984).…”