Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum

Lee, Sang‐Hyun; Shim, Sang Hee; Kim, Ju Sun; Shin, Kuk Hyun; Kang, Sam Sik

doi:10.1248/bpb.28.1103

Cited by 48 publications

(25 citation statements)

References 28 publications

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“…Lee et al have previously shown that an EtOAc fraction from the fruiting bodies of another Ganoderma genus, namely G. applana- tum, was the most active fraction against the rat lens aldose reductase (RLAR). They reported that protocatechualdehyde and ergosterol peroxide showed significant inhibitory activity against RLAR among 15 isolated compounds from the fruiting bodies of G. applanatum [15,16]. In the present study, ganoderic acid C2 (1) and ganoderenic acid A (2) showed high inhibitory activity.…”

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confidence: 54%

Inhibition of Aldose ReductaseIn Vitroby Constituents ofGanoderma lucidum

2010

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CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

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confidence: 54%

Inhibition of Aldose ReductaseIn Vitroby Constituents ofGanoderma lucidum

2010

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“…Some sulfated flavonoids in Polygonum hydropiper were discovered to show potent inhibition against bovine lens aldose reductase (Haraguchi et al, 1996). Other studies showed that flavonoid glycosides (Haraguchi et al, 1998), isoflavonoids (Jung et al, 2002), flavanone glucosides (myrciacitrins III) (Suryanarayana et al, 2004), protocatechualdehyde (Suryanarayana et al, 2002) and tannoid principles (Lee et al, 2005) had strong inhibitory activity. Plants which are rich in polyphenols and bioflavonoids are reported to reduce the AR activity.…”

Section: Discussionmentioning

confidence: 99%

Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants

Patel¹,

Mishra²

2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYAldose reductase (AR) has been reported to play an important role in sugar-induced cataract. In the present study, the AR inhibitory activity of Enicostemma hyssopifolium (EH), Gymnema sylvestre, Eclipta alba, and Tinospora cordifolia (TC) were studied along with their effect on sugar-induced cataractogenic changes in sheep lenses in vitro. AR inhibitory activity of the aqueous extracts of plants and their anticataract potentials were evaluated in vitro in sheep lenses, considering the activity of normal sheep lenses as 100%. The concentration of the plant extract that showed maximum activity was selected to further study its effect on galactose-induced polyol accumulation in vitro. The IC 5 0 values of EH and TC were calculated to be 102 and 85 µg/ml, respectively. EH showed a significant inhibition (61.3%) in polyol accumulation followed by TC (53.1%). EH and TC possesses a significant anticataract activity in vitro and its anticataract potential could be related with its AR inhibitory effect.

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“…Park, Ahn, Ka, & S. Park, 2007;Nakashima, Umeda, & Kanada, 1979;Sasaki, Arai, Ikekawa, Chihara, & Fukuoka, 1971;Usui, Iwasaki, & Mizuno, 1981 Usui et al, 1983;Yang, Sun, Yu, Cui, & Tian, 2005) from the fruiting bodies of G. applanatum. Our previous investigations on the fruiting bodies of G. applanatum resulted in the isolation of a series of lanostane-type triterpenes, simple phenolics and other molecules with aldose reductase inhibitory activity (Jung et al, 2005;Lee et al, 2006;Lee, Shim, Kim, Shin, & Kang, 2005;Shim et al, 2004). The fruiting bodies of G. applanatum have not been cultivated for commercialisation to date.…”

Section: Introductionmentioning

confidence: 99%

Polyoxygenated ergostane-type sterols from the liquid culture ofGanoderma applanatum

Lee

Kim

Lee

et al. 2011

Natural Product Research

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A new polyoxygenated ergostane-type sterol, 3β,5α,6β,8β,14α-pentahydroxy-(22E,24R)-ergost-22-en-7-one (1), has been isolated from the liquid culture of the basidiomycete Ganoderma applanatum together with four known sterols, 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2), ergosterol peroxide (3), 6-dehydrocerevisterol (4) and cerevisterol (5). Two of these sterols (2, 4) are reported to have been isolated from this species for the first time. The structures of these compounds were determined by chemical and spectroscopic analyses, including 1D- and 2D-NMR, as well as by comparison of their spectroscopic data with those reported in the literature.

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Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum

Cited by 48 publications

References 28 publications

Inhibition of Aldose ReductaseIn Vitroby Constituents ofGanoderma lucidum

Inhibition of Aldose ReductaseIn Vitroby Constituents ofGanoderma lucidum

Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants

Polyoxygenated ergostane-type sterols from the liquid culture ofGanoderma applanatum

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