Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects

Haddad, John J.

doi:10.1016/j.bbrc.2004.08.119

Cited by 36 publications

(26 citation statements)

References 70 publications

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“…Our sample had 91% power to detect a < 0.05 at the OR observed. Exploratory analyses revealed associations with lifetime prevalence for drunkenness for both SNPs as well as lifetime prevalence for alcohol intake in SNP (8). No association was found with measures of frequency of drinking.…”

Section: Discussionmentioning

confidence: 85%

“…[28][29][30][31][32][33][34] The six SNPs with potential function are all grouped in one haplotype block, which is defined by htSNP (8), as shaded grey in Table 3. htSNP (8) integrates all potentially functional genetic variations investigated in this study. Association of htSNPs with alcohol consumption and binge drinking in the adolescent sample The consumption of the first complete glass of alcohol of the adolescent subjects of the MARC study was at an average age of 13.2371.05 years.…”

Section: Genetic Analysis Of the Crhr1 Genementioning

confidence: 99%

“…We hypothesised that the risk genotypes of CRHR1 htSNPs (4) and (8) are also associated with the increased alcohol intake in adult alcohol-dependent patients. In our second sample, patients with high alcohol intake ( > 250 g/day) were compared to those drinking less than or equal to 250 g/day.…”

Section: Genetic Analysis Of the Crhr1 Genementioning

confidence: 99%

“…6 Alcohol intake leads to an increased secretion of CRH and can stimulate HPA axis activity. 7,8 The activation of the CRHR1 induces the production of second-messenger cAMP in the target cells and stimulates the production of adrenocorticotropic hormone (ACTH) in the anterior pituitary. 9 The primary target of ACTH is the adrenal gland, where it binds to the ACTH receptors to release glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

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Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples

et al. 2006

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To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, which consisted of individuals from the 'Mannheim Study of Risk Children' (MARC), who had little previous exposure to alcohol, and a sample of alcohol-dependent adults, who met DSM-IV criteria of alcohol dependence. Following determination of allelic frequencies of 14 polymorphisms of the CRHR1 gene, two haplotype tagging (ht)SNPs discriminating between haplotypes with a frequency of X0.7% were identified. Both samples were genotyped and systematically examined for association with the htSNPs of CRHR1. In the adolescent sample, significant group differences between genotypes were observed in binge drinking, lifetime prevalence of alcohol intake and lifetime prevalence of drunkenness. The sample of adult alcohol-dependent patients showed association of CRHR1 with high amount of drinking. This is the first time that an association of CRHR1 with specific patterns of alcohol consumption has been reported. Our findings support results from animal models, suggesting an importance of CRHR1 in integrating geneenvironment effects in alcohol use disorders.

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Section: Discussionmentioning

confidence: 85%

Section: Genetic Analysis Of the Crhr1 Genementioning

confidence: 99%

Section: Genetic Analysis Of the Crhr1 Genementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples

et al. 2006

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“…Among its many effects, alcohol influences immune function mainly through the HPA: acute alcohol exposure stimulates the HPA to release neural immunomodulators (Haddad, 2004). Studies in C. elegans have identified presynaptic proteins, including RAB-3 and UNC-18, as ethanol targets, suggesting that ethanol influences neuronal function by affecting crucial steps of vesicle priming (Kapfhamer et al, 2008;Graham et al, 2009).…”

Section: Alcoholmentioning

confidence: 99%

It takes nerves to fight infections: insights on neuro-immune interactions fromC. elegans

Kawli

Tan

2010

Disease Models &Amp; Mechanisms

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The innate immune response is evoked as a consequence of interactions between invading foreign infectious agents and host immune cells. A successful innate immune response is pivotal in maintaining the delicate balance between health and disease; an insufficient response results in infection, whereas an excessive response results in prolonged inflammation and tissue damage. Alterations in the state and function of the nervous system influence the immune response. The nervous system regulates innate immune responses through the release of neurotransmitters, neuropeptides and neurohormones. However, many questions related to the molecular and cellular mechanisms involved, the physiological role of the link between the immune and the nervous system, and the biological significance of neuro-immune interactions remain unresolved. The interactions between the nematode Caenorhabditis elegans and its pathogens provide insights into mechanisms of neuroendocrine regulation of immunity and address many outstanding issues related to neuro-immune interactions.

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In Utero Alcohol Exposure and Prediction of Alcohol Disorders in Early Adulthood

Alati¹,

Mamun²,

Williams³

et al. 2006

Arch Gen Psychiatry

202

161

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Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects

Cited by 36 publications

References 70 publications

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples

It takes nerves to fight infections: insights on neuro-immune interactions fromC. elegans

In Utero Alcohol Exposure and Prediction of Alcohol Disorders in Early Adulthood

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