Alcoholic ketoacidosis as a cause of death in forensic cases

Thomsen, Jørgen Lange; Felby, Søren; Theilade, Peter; Nielsen, Erik

doi:10.1016/0379-0738(95)01783-6

Cited by 86 publications

(60 citation statements)

References 17 publications

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“…Determination of ketone bodies in corpse fluid and its application to forensic practice has been analysed by several authors [7][8][9][10][11][12][13]. β-OHB serum concentrations provide more information about severity of ketoacidosis whether it is related to diabetes [14], alcohol [9] or starvation [15] than other ketone bodies.…”

Section: Ketone Bodiesmentioning

confidence: 99%

Disorders of glucose metabolism: post mortem analyses in forensic cases–part II

2010

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In continuation to part I, a literature review is presented concerning biochemical problems of forensic post mortem cases of unclear hyperglycaemia or hypoglycaemia. Clinical parameters for this purpose were recently reviewed. Particular attention was paid to the detection of diabetic ketoacidosis, of hyperosmolar coma, insulinoma, insulin-induced or oral diabetic-induced hypoglycaemia. The second part of the review discusses the analytes ketone bodies, synthetic insulins, human insulin, C-peptide, proinsulin and insulin antibodies. Special interest is given to post mortem matrices for those analytes to reference concentrations, stability data, analytic interferences and analytical procedures which should be used in toxicological laboratories willing to detect diabetic metabolism disorders after death.

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Section: Ketone Bodiesmentioning

confidence: 99%

Disorders of glucose metabolism: post mortem analyses in forensic cases–part II

2010

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“…Another alcohol-related death sometimes encountered in legal medicine is alcoholic ketoacidosis, which implies abnormally high concentration of ketone bodies in blood, particular β-hydroxybutyrate (Thomsen et al 1995). In this type of death, the victim is often known to have been a heavy drinker or alcoholic, but BAC at autopsy is usually low or close to zero.…”

Section: Discussionmentioning

confidence: 99%

Toxicology of Specific Substances

Jones

Mußhoff

Kræmer

et al. 2014

Handbook of Forensic Medicine

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“…1 Prognosis is usually excellent but complications such as acute pancreatitis, Wernicke's encephalopathy, rhabdomyolysis, congestive heart failure, diabetic ketoacidosis and death have also been reported. [4][5][6][7][8] In conclusion, AKA is usually seen in chronic alcohol abuse. Patients can present with a mixed acid-base disorder, but the primary component is wide anion-gap metabolic acidosis.…”

Section: Discussionmentioning

confidence: 99%