Alcohol Intake and the Risk of Cardiovascular Disease in Middle-Aged Japanese Men

Iso, Hiroyasu; Kitamura, Akihiko; Satō, Takashi; Sankai, Tomoko; Naito, Yoshihiko; Sato, Shinichi; Kiyama, Masahiko; Iida, Minoru; Komachi, Yoshio

doi:10.1161/01.str.26.5.767

Cited by 137 publications

(101 citation statements)

References 36 publications

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“…1 Alcohol drinking habit was related to hypertension, consistent with the results of previous studies in Japan. 30,31 However, we found no association between cigarette smoking and blood pressure. Higher serum HDL cholesterol levels and lower AI were observed among non-smokers.…”

Section: Discussioncontrasting

confidence: 80%

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

Kawada

2002

Int J Obes

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OBJECTIVE:The association between body mass index (BMI) and cardiovascular risk factors, widely recognized in Western populations, was evaluated on subjects living in a rural Japanese area. DESIGN: A cross-sectional survey. SUBJECTS: A total of 16 871 subjects aged 40 -59 y, from a rural area in Japan, participated in an annual health examination. All of the subjects were required to answer six items in a questionnaire on health behavior and provide blood samples. MEASUREMENTS: Quetelet's index, blood pressure, total cholesterol, high-density lipoprotein cholesterol, health practices on exercise, drinking and smoking. RESULTS: The mean BMI in the population was 23.1 AE 2.9. After adjustment for sex, age and six health habits, the BMI was found to be significantly associated with blood pressure and the serum lipid levels by multivariate logistic regression analysis. The adjusted odds ratio for hypertension ( ! 140=90 mmHg) against the lowest quartiles of BMI (separated by 20, 25 and 28) were 1.6, 2.8 and 5.2, respectively. The adjusted odds ratio for hypercholesterolemia ( ! 240 mg=dl) against the lowest quartiles of BMI were 2.1, 3.3 and 4.6, respectively. CONCLUSION: There was a significant relationship between the BMI and cardiovascular risk factors in a rural Japanese population. This association could be extended to lower BMI levels than those in Western populations.

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Section: Discussioncontrasting

confidence: 80%

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

Kawada

2002

Int J Obes

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“…However, nonsignificant correlation with TG or LDL-C has been reported (50). Heavy drinking appeared to increase the risk of stroke and sudden death in a prospective study (51). In addition, cigarette smoking is known to be associated with increases in plasma TG concentration and decreases in plasma HDL-C concentration, and also to cause insulin resistance (52).…”

Section: Discussionmentioning

confidence: 99%

The Relationships of Testosterone, Estradiol, Dehydroepiandrosterone-sulfate and Sex Hormone-binding Globulin to Lipid and Glucose Metabolism in Healthy Men

Shono

Kumagai

Higaki

et al. 1996

J Atheroscler Thromb

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We investigated the relationships of plasma sex hormones (free testosterone ; free T, estradiol ; E2, dehydroepiandrosterone-sulfate ; DHEA-S) and sex hormone-binding globulin (SHBG) levels to lipid and glucose metabolism cross-sectionally in 212 apparently healthy men aged from 18 to 59 years. A multiple linear regression analysis for lipid and glucose parameters with age, body mass index (BMI), percent body fat (%fat), waist to hip ratio (WHR), estimated maximal oxygen uptake (VO2max), alcohol and cigarette consumption, sex hormones, and SHBG, respectively, as independent variables, was performed. DHEA-S was indicated as one of the independent predictors of both high density lipoprotein cholesterol (HDL-C), with a positive relation, and of triglyceride and total cholesterol/HDL-C ratio, with a negative relation, while SHBG was one of the predictors of both HDL-C, with a positive relation, and of fasting insulin, with a negative relation. The E2 level was found to be negatively related to both low density lipoprotein cholesterol and fasting blood glucose. These findings thus suggest that the higher levels of SHBG, DHEA-S and E2 within physiological ranges in healthy men may partially help to maintain a desirable profile of the plasma lipid and glucose metabolism.

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“…The dose-response pattern between alcohol consumption and BP in the present subjects was, therefore, considered to be a linear one, as has been often recognised in the studies in Japanese. 22,23 Journal of Human Hypertension…”

Section: Discussionmentioning

confidence: 99%

Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers

et al. 2002

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Orientals have unique genetic polymorphisms in ethanol metabolizing enzymes, such as alcohol dehydrogenase-2 (ADH2), aldehyde dehydrogenase-2 (ALDH2) and cytochrome P450-2E1 (CYP2E1). Of the three studies conducted to clarify the influence of ALDH2 genotypes on sensitivity to the pressor effects of alcohol in Japanese, only one was suggested, though indirectly, higher sensitivity in drinkers having the genotype of inactive ALDH2. This discrepancy prompted us to determine ADH2, ALDH2 and CYP2E1 genotypes in the genomic DNA extracted from white blood cells of 855 healthy middle-aged Japanese men, and to analyse the associations with the alcohol-blood pressure (BP) relationship. No marked differences were found in the relationship among the genotypes of ALDH2, although the subjects with intact ALDH2 showed a slightly higher

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Alcohol Intake and the Risk of Cardiovascular Disease in Middle-Aged Japanese Men

Cited by 137 publications

References 36 publications

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population

The Relationships of Testosterone, Estradiol, Dehydroepiandrosterone-sulfate and Sex Hormone-binding Globulin to Lipid and Glucose Metabolism in Healthy Men

Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers

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