Alcohol Induces More Severe Fatty Liver Disease by Influencing Cholesterol Metabolism

Li, Bo; Lei, Shanshan; Shi, Jie; Cai, Xia-Miao; Hu, Xu; He, Xinglishang; Chen, Ye‐Hui; Lü, Hongyan; He, Li; Qian, Liu-Qing; Zheng, Xiang; Lv, Gui‐Yuan; Chen, Suhong

doi:10.1155/2019/7095684

Cited by 16 publications

(28 citation statements)

References 44 publications

(68 reference statements)

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“…Sample to solvent ratio (g/mL) 1:10 1:30 1:50 X 3 Extraction temperature ( • C) 40 60 80 X 4 Extraction time (h) 6 12 18…”

Section: Experiments Factors Coded Levelsmentioning

confidence: 99%

“…The reactive oxygen species (ROS) generated from excessive alcohol consumption are known to oxidize intracellular macromolecules, such as DNA, proteins, and lipids, and induce oxidative stress in the liver, causing functional damages. If the liver injury persists, the condition advances to alcoholic fatty liver disease [3,4]. A large number of recent studies have focused on developing materials from various medicinal plants that can prevent alcoholic liver injury without side effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Eom

Kim

2020

Antioxidants

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The response surface methodology was used to optimally extract the antioxidant substances from Dendropanax morbifera leaves. The central composite design was used to optimally analyze the effects of ethanol concentration, sample to solvent ratio, extraction temperature, and extraction time on the total flavonoids (TF) content, ferric reducing antioxidant power (FRAP), and Trolox equivalent antioxidant capacity (TEAC). All three parameters were largely influenced by the ethanol concentration and extraction temperature, while TEAC was also influenced by the sample to solvent ratio. The maximum values of TF content, FRAP, and TEAC were achieved under the following extraction conditions: 70% ethanol, 1:10 sample to solvent ratio, 80 °C, and 14 h. The D. morbifera leaf extracts (DMLE) produced under these optimum extraction conditions were investigated to determine their preventive effects on alcohol-induced liver injury. The DMLE was shown to prevent liver injury by scavenging the reactive oxygen species generated by alcohol. In addition, composition analysis of DMLE found high contents of chlorogenic acid and rutin that were determined to inhibit alcoholic liver injury. The findings of this study suggest that DMLE could prove useful as a functional food product supplement to prevent liver injury caused by excessive alcohol consumption.

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“…Sample to solvent ratio (g/mL) 1:10 1:30 1:50 X 3 Extraction temperature ( • C) 40 60 80 X 4 Extraction time (h) 6 12 18…”

Section: Experiments Factors Coded Levelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Eom

Kim

2020

Antioxidants

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“…had previously stated that chronic alcohol consumption causes increased ferritin concentration and serum transferrin saturation, and also elevated hepatic iron stores [ 45 ]. Alcohol also increases cholesterol metabolism in the liver by elevating its synthesis, absorption, and excretion while limiting the absorption of cholesterol in the intestines [ 31 , 46 ]. Silva et al.…”

Section: Discussionmentioning

confidence: 99%

Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron

Lobo

Liu

Song

et al. 2020

Heliyon

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Background Lifestyle involving uncontrolled alcohol consumption coupled regularly with red meat and other iron sources has detrimental effects on the liver, which in the long term, results in Alcoholic Liver Disease (ALD). Procyanidin has lately garnered increasing attention and has become the focus of research owing to its antioxidant properties. This study explores the anti-inflammatory effects of procyanidins, in preventing ALD, by analyzing the biological activities of the compound on liver injury caused by excessive alcohol and iron. Method Male SPF Wistar rats were placed in 4 groups; the control Group A (basic diet); the model Group B (excess alcohol 8–12 mL/kg/d and iron 1000 mg/kg diet); the low dose procyanidin Group C (model group diet plus 60 mg/kg/d of procyanidin); and the high dose procyanidin Group D (model group diet plus 120 mg/kg/d of procyanidin). Serum biochemical markers for liver damage were measured spectrophotometrically. The NFκB and IκB mRNA expression levels were determined using RT-PCR; the NFκB p65 and IκB protein expression levels were assessed via western blotting, while ELISA was used to detect serum inflammatory factors. Results The pathological score of the model Group B, low and high dose procyanidin Groups C and D were 6.58 ± 0.90,4.69 ± 0.70 and 2.00 ± 0.73, respectively (P < 0.05). The results showed that high alcohol and iron contents in the model group led to significant damage of liver structure, increased low-density lipoproteins (LDLs), steatosis, and increased levels of inflammatory cytokines. High amounts of procyanidins led to the preservation of the liver structure, production of high-density lipoproteins, and reduction in serum inflammatory cytokines while also significantly decreasing the expression levels of NFκB p65. Conclusion The results prove that procyanidins have hepatoprotective potential and could be effective in reversing histopathology, possibly by alleviating inflammation and improving lipid metabolism.

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“…Histological Staining of Liver Section. Hematoxylin-eosin (H&E) and Oil Red O staining were performed according to our previous literature studies [14,20,21]. Oil Red O staining can be used to identify the lipid accumulation and quantify hepatic steatosis.…”

Section: 4mentioning

confidence: 99%

Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice

Lei

Zhang

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Dendrobium officinale (DOF) is a traditional Chinese edible and officinal plant. Ultrafine DOF powder (DOFP) can regulate lipids and histopathology in the liver, but the underlying mechanisms of hepatic fatty acid (FA) metabolism, which is generally correlated with the development of nonalcoholic fatty liver disease (NAFLD), remain unclear. The purpose of the present study was to investigate whether DOFP treatment alters hepatic FA metabolism in NAFLD mice by using multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) and analyse the underlying mechanisms. A 3-week DOFP treatment prevented lipid deposition and improved hepatic histopathology in NAFLD mice after withdrawal from the high-sucrose, high-fat (HSHF) diet, and it decreased triglyceride and FA content in the liver. Furthermore, the C16 : 0/C14 : 0 and C18 : 1/18 : 0 ratios in FAs were significantly decreased in the DOFP treatment group, and the C20 : 4/C20 : 3 and C22 : 4/C22 : 3 ratios were increased, and saturated FA was inhibited. Additionally, DOFP treatment significantly increased the content of two FA β-oxidation-related proteins (carnitine palmitoyltransferase 1-α and acyl-coenzyme A oxidase 1). It also decreased the content of a FA synthesis-related protein (fatty acid synthase), a FA desaturation-related protein (stearoyl-coenzyme A desaturase-1), and a FA uptake-related protein (fatty acid transport protein 2). Moreover, DOFP treatment improved dysregulated levels of major phospholipids in the livers of model mice. The results of this study confirm that DOFP treatment in NAFLD mice has liver recovery effects by regulating FA metabolism.

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Alcohol Induces More Severe Fatty Liver Disease by Influencing Cholesterol Metabolism

Cited by 16 publications

References 44 publications

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Dendropanax morbifera Leaf Polyphenolic Compounds: Optimal Extraction Using the Response Surface Method and Their Protective Effects against Alcohol-Induced Liver Damage

Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron

Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice

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