Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats

Mallikarjuna, K.; Shanmugam, Kirubanandan; Nishanth, K.; Wu, Ming-Chieh; Hou, Chien-Wen; Kuo, Chia‐Hua; Reddy, K. Pratap

doi:10.1016/j.alcohol.2010.07.004

Cited by 39 publications

(31 citation statements)

References 36 publications

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“…Previous studies that evaluated the effect of water consumption with 20% of ethanol in young male (3 months) and aged (18 months) rats, a decrease in the activity of hepatic SOD in both phases was detected, which can be related to the age of the animals. 21 In another study with adult male Wistar rats were offered from 5 to 9 g/kg of ethanol for 12 days and there was also a decreased in the activity of hepatic SOD. 22 This decreased in hepatic SOD activity can consequently result in an increase of lipid peroxidation, nitrotyrosine accumulation, extensive centrilobular necrosis and inflammation.…”

Section: Discussionmentioning

confidence: 98%

Ethanol in lactation promotes oxidative stress in different phases of rat offspring

et al. 2014

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Section: Discussionmentioning

confidence: 98%

Ethanol in lactation promotes oxidative stress in different phases of rat offspring

et al. 2014

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“…Then, analysis of variance (ANOVA) followed by Regarding animal experimentation, the minimum sample size was defined according to an estimated variance previously described in literature [20,[24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…Some limitations of this study were the lack of control of the amount of water and diet consumed by animals; the lack of liver biopsy of animals at the end of alcohol consumption to evaluate histology prior to physical training, which would allow a comparison of the magnitude of changes caused by alcohol; the lack of serial biopsies during physical training to observe changes over time; control animals received water by gavage at the same time in view to avoid placebo effect, but it was stopped after 10 days to avoid unnecessary injury and suffering; others trials used longer exercise protocols: 6.5 to 8 weeks [24,25,36].…”

Section: Limitationsmentioning

confidence: 99%

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Lucca¹,

Pereira²,

Righi³

et al. 2018

JPP

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Abstract:Objectives: To investigate the effects of physical training on the liver morphology and morphometry after chronic use of alcohol in rats. Methods: Twenty-four Wistar rats were housed in cages with controlled environment and randomly divided into four groups according to treatment received. In the initial treatment, alcohol was administered to SA (sedentary alcohol) and EA (exercise alcohol) groups. After four weeks, physical training program was held on a treadmill with EA and EC (exercise control) groups. Area, perimeter, maximum and minimum diameter and form factor of nucleus and cytoplasm of hepatocytes were analyzed. Key findings: Micro-vesicular fatty degeneration, predominantly pericentrolobular, of mild to moderate intensity, was found especially in animals treated with alcohol. EC group showed nucleus area greater than the nucleus area of EA and SA groups. The form factor was lower in the EC group than in the EA group. EA group showed maximum cytoplasm diameter is smaller than in SC (sedentary control) group. Conclusions: Physical training for two weeks was not enough to suppress histopathologic changes in the liver caused by chronic use of alcohol in rats. Chronic use of alcohol seems to have minimized the beneficial effect of physical training in the nucleus area of hepatocytes.

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“…Serum GSH and the levels of its associated enzymes are decreased in ageing in humans [79]. In rats, this age-related decrease has been shown to be further exacerbated by ethanol consumption [80] which may be a problem in chronic alcoholics.…”

Section: Liver Specific Changes In Ageingmentioning

confidence: 99%

Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol

Mitchell

Kane

Hilmer

2011

Current Gerontology and Geriatrics Research

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Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.

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Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats

Cited by 39 publications

References 36 publications

Ethanol in lactation promotes oxidative stress in different phases of rat offspring

Ethanol in lactation promotes oxidative stress in different phases of rat offspring

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol

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