Alcohol-Induced Bone Loss and Deficient Bone Repair

Chakkalakal, Dennis A.

doi:10.1097/01.alc.0000192039.21305.55

Cited by 209 publications

(153 citation statements)

References 127 publications

(228 reference statements)

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“…We have extended ibandronate and vitamin D treatment options to studies in rats with binge alcohol-related bone damage, a condition expressed in the human population. It is well-understood that bone remodeling is altered when blood alcohol concentrations remain significantly elevated for continuous periods of time or during repeated binge cycles in male rats [3,5,[26][27][28]. Consequently, an imbalance is created between formation and resorption characterized by reduced formation and increased resorption.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats

Wezeman¹,

Juknelis²,

Himes³

et al. 2007

Bone

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Decreased bone mass and bone strength can result from excess alcohol consumption in humans and alcohol treatment in the rat. Although the specific mechanism is unknown, the damaging effects of alcohol abuse modulate the bone remodeling cycle and increase bone turnover. Chronic alcohol consumption models have shown an inhibition of bone formation. We previously reported that binge alcohol treatment increases bone resorption and that alcohol-induced damage can be prevented by treatments with intermittent parathyroid hormone and bisphosphonates. In this study we hypothesized that an effective dose of vitamin D (cholecalciferol) or a single dose of ibandronate would prevent bone loss caused by binge alcohol treatment in male rats. Forty-eight adult (450 gram) male Sprague-Dawley rats were randomly assigned to 6 treatment groups (n=8): a) saline, i.p.3 days/ week (C); b) binge alcohol, 3g/kg i.p., 3 days/week (A); c) vitamin D, 5,000 IU/kg daily s.c., (D); d) binge alcohol and vitamin D (AD); e) e) ibandronate, (120 ug, given as a single i.p. injection (I); f) alcohol and ibandronate (AI). After 4 weeks of treatment proximal tibia and L3 and L4 vertebrae were analyzed for bone mineral density (BMD) by quantitative computerized tomography and compressive strength-to-failure using an Instron materials testing machine. Type-I collagen crosslinked c-telopeptide, calcium, and 25-OH vitamin D levels were measured in serum collected at the time of sacrifice. Binge alcohol significantly decreased cancellous BMD by 58% in tibia and 23% in lumbar spine (p < 0.05). Binge alcohol treatment decreased L3 and L4 compressive strength-tofailure by 21% (p <.05). Treatment with vitamin D at 5,000 IU/kg/day prevented alcohol-induced bone loss, significantly increasing both tibial and vertebral cancellous BMD values (161% increase in tibia and 40% increase in vertebra, respectively, p < 0.05) compared to alcohol alone groups. Pretreatment with the single dose of 120 ug ibandronate prevented alcohol-induced bone loss, increasing cancellous BMD by 186% in tibiae and by 46% in vertebrae compared to the alcohol alone group (p < 0.05). In summary, binge alcohol-induced tibial and vertebral bone loss can be prevented using an effective dose of vitamin D or a single dose of ibandronate even during high blood alcohol concentrations that have been shown to impair osteoblast functions and increase bone resorption.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats

Wezeman¹,

Juknelis²,

Himes³

et al. 2007

Bone

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“…14 alcohol has a dose-dependent toxic influence on osteoblast activity [32].The effect of longterm alcohol consumption on bone remodeling likely involves a complex uncoupling of formation and resorption with a decreased bone formation rather than increased bone resorption [32]. Data from experimental studies indicate that osteocalcin (a marker of bone formation) increases after abstinence [33] and decreases after alcohol administration [34].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Paccou

Edwards

Ward

et al. 2015

Bone

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Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption, Bone (2015), doi: 10.1016/j.bone. 2015.05.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and Professor of Musculoskeletal Science, University of Oxford. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Contact details:MRC Lifecourse Epidemiology Unit, (University of Southampton), socioeconomic status and years since menopause and HRT use for women), men that drank low alcohol had lower cortical thickness (p=0.038), cortical vBMD (p=0.033), and trabecular vBMD (p=0.028) and higher trabecular separation (p=0.043) than those that drank none/minimal alcohol. Similar differences were shown between minimal/none and moderate/high alcohol although these only reached statistical significance for the cortical parameters. Interestingly, after similar adjustment, women showed similar differences in the trabecular compartment between none/minimal alcohol and low alcohol at the distal tibia.However, women that drank moderate/high alcohol had significantly higher trabecular vBMD (p=0.007), trabecular thickness (p=0.026), and trabecular number (p=0.042) and higher trabecular separation (p=0.026) at the distal radius than those that drank low alcohol.Conclusions: Our results suggest that alcohol consumption (low and moderate/high) may have a detrimental impact on bone health in men in both the cortical and trabecular A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT4 compartments at the distal radius with similar results in women in the trabecular compartment between none/minimal alcohol and low alcohol at the distal tibia suggesting that avoidance of alcohol may be beneficial for bone health.Keywords: alcohol consumption, high-resolution peripheral quantitative computed tomography, bone geometry, microarchitecture, volumetric bone mineral density.Highlights:1/ Men that drank low alcohol had lower Ct.Th, Ct.vBMD, Tb.vBMD and higher Tb.Sp at the distal radius than those that drank none/minimal alcohol.2/ Low levels of alcohol consumption are not beneficial for bone health.3/ There is a site-and sex-dependent effect of alcohol consumption on bone health.

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“…Depression is associated with smoking [52], which is associated with lower BMD by inhibiting estrogen activity and inhibiting calcium absorption by the intestines [53]. Depression is also associated with increased alcohol use [54], and chronic alcohol use is also associated with low BMD by inhibition of bone cell proliferation and function [55,56]. Depression is associated with fatigue and physical inactivity [57,58], and physical activity is associated with increased BMD [36].…”

Section: Behaviorsmentioning

confidence: 99%

Depression and osteoporosis: epidemiology and potential mediating pathways

2007

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Introduction-There have been numerous studies examining the association between depression and bone mineral density (BMD), but the underlying nature of this relationship remains unclear. Independent of this association, there is a growing body of evidence that depression impacts the risk for fracture in older adults. This article reviews the current epidemiological evidence regarding comorbidity of depression, low bone mineral density, and fracture.

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Alcohol-Induced Bone Loss and Deficient Bone Repair

Cited by 209 publications

References 127 publications

Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats

Vitamin D and ibandronate prevent cancellous bone loss associated with binge alcohol treatment in male rats

Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Depression and osteoporosis: epidemiology and potential mediating pathways

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