Alcohol: Friend or FOE? Alcoholic Beverage Hormesis for Cataract and Atherosclerosis is Related to Plasma Antioxidant Activity

Prickett, Claire D.; Lister, E.; Collins, Michelle M.; Trevithick-Sutton, Colleen C.; Hirst, Maurice; Vinson, Joe A.; Noble, E. C.; Trevithick, John R.

doi:10.1080/15401420490900272

Cited by 17 publications

(14 citation statements)

References 35 publications

(79 reference statements)

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“…There is no doubt that alcohol, wine, and wine‐derived resveratrol all display hormesis. It has been known for quite some time that cardioprotective effects of alcohol or wine intake follow a J‐shaped curve 85 . This study (D. Das, J. Clin.…”

Section: Resveratrol and Hormonesmentioning

confidence: 89%

Resveratrol in cardiovascular health and disease

Petrovski¹,

Gurusamy²,

Das³

2011

Annals of the New York Academy of Sciences

211

132

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Resveratrol, initially used for cancer therapy, has shown beneficial effects against most degenerative and cardiovascular diseases from atherosclerosis, hypertension, ischemia/reperfusion, and heart failure to diabetes, obesity, and aging. The cardioprotective effects of resveratrol are associated with its preconditioning-like action potentiated by its adaptive response. During preconditioning, small doses of resveratrol can exert an adaptive stress response, forcing the expression of cardioprotective genes and proteins such as heat shock and antioxidant proteins. Similarly, resveratrol can induce autophagy, another form of stress adaptation for degrading damaged or long-lived proteins, as a first line of protection against oxidative stress. Resveratrol's interaction with multiple molecular targets of diverse intracellular pathways (e.g., action on sirtuins and FoxOs through multiple transcription factors and protein targets) intertwines with those of the autophagic pathway to give support in the modified redox environment after stem cell therapy, which leads to prolonged survival of cells. The successful application of resveratrol in therapy is based upon its hormetic action similar to any toxin: exerting beneficial effects at lower doses and cytotoxic effects at higher doses.

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Section: Resveratrol and Hormonesmentioning

confidence: 89%

Resveratrol in cardiovascular health and disease

Petrovski¹,

Gurusamy²,

Das³

2011

Annals of the New York Academy of Sciences

211

132

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“…Specifically, moderate alcohol consumption increased expression of HLA-F, IL-15B, IL-2Rb, IL-1R, K-ras, while decreasing expression of NFκB, Stat5A, TIMP2, and Tapasin [15]. Finally, moderate alcohol consumption increases plasma antioxidant levels while alcohol abuse increases plasma pro-oxidant activity [19]. …”

mentioning

confidence: 99%

Could moderate alcohol intake be recommended to improve vaccine responses?

Messaoudi

Pasala

Grant

2014

Expert Review of Vaccines

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Summary The impacts of alcohol consumption on human health are complex and modulated by several factors such as patterns and amounts of drinking, genetics, the organ system studied, as well as the sex and the age of the user. There is strong evidence that chronic ethanol abuse is associated with increased morbidity and mortality, immunosuppression, and increased susceptibility to both bacterial and viral infections. In contrast, moderate alcohol consumption exerts positive effects including decreased mortality, and improved cardiovascular disease and insulin sensitivity. Interestingly, accumulating evidence also supports an immune boosting effect of moderate alcohol. In this editorial, we summarize the findings that support a positive effect of moderate alcohol on host immunity. We also discuss the limitations of the previous data and emphasize the importance of additional studies to uncover mechanisms for these immune-stimulating effects in order to extend these benefits to vulnerable segments of the population who cannot consume alcohol.

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“…Prickett et al [40] reported that one drink of red wine, beer, or stout (5% alcohol) resulted in increased plasma antioxidant activity for up to 4 h after consumption, but consumption of three drinks of wine, beer, or stout made the plasma pro-oxidant and the effect lasted almost 6 h after consumption of alcohol. However, when wine, beer, and stout were tested separately, all showed antioxidant activities in vitro, although red wine showed higher antioxidant capacity due to higher levels of antioxidant polyphenolic compounds.…”

Section: Antioxidant and Pro-oxidant Effects Of Alcoholic Beveragesmentioning

confidence: 97%

“…However, when volunteers consumed alcohol solution comparable to consumption of three drinks, plasma showed pro-oxidant properties. Metabolism of alcohol is known to produce reactive oxygen species [40]. Puddey et al [41] also noted that although in vitro experiments have indicated that extracts of red wine, white wine, grape juice, and beer can inhibit oxidation of low-density lipoprotein (LDL) and the degree of inhibition is usually directly related to polyphenolic content of the beverages, these in vitro antioxidant effects cannot be reproduced in vivo after consumption of alcoholic drinks, especially with increasing numbers of drinks.…”

Section: Antioxidant and Pro-oxidant Effects Of Alcoholic Beveragesmentioning

confidence: 98%