Resveratrol in cardiovascular health and disease

Petrovski, Goran; Gurusamy, Narasimman; Das, Dipak K.

doi:10.1111/j.1749-6632.2010.05843.x

Cited by 211 publications

(141 citation statements)

References 90 publications

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“…Because of their lower toxicity, traditional Chinese medicines should be considered for disease therapy by autophagic regulation. Recently, it was reported that the therapeutic effects of resveratrol [121] and oridonin [122] were both related to autophagy. Our studies also show that paeoniflorin, the principal bioactive component of Radix Paeoniae alba, potently protected PC12 cells against MPP + or acidosis-induced injury by upregulating the autophagic pathway [123] .…”

Section: Therapeutic Implications For Autophagy Regulatorsmentioning

confidence: 99%

Application and interpretation of current autophagy inhibitors and activators

et al. 2013

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Autophagy is the major intracellular degradation system, by which cytoplasmic materials are delivered to and degraded in the lysosome. As a quality control mechanism for cytoplasmic proteins and organelles, autophagy plays important roles in a variety of human diseases, including neurodegenerative diseases, cancer, cardiovascular disease, diabetes and infectious and inflammatory diseases. The discovery of ATG genes and the dissection of the signaling pathways involved in regulating autophagy have greatly enriched our knowledge on the occurrence and development of this lysosomal degradation pathway. In addition to its role in degradation, autophagy may also promote a type of programmed cell death that is different from apoptosis, termed type II programmed cell death. Owing to the dual roles of autophagy in cell death and the specificity of diseases, the exact mechanisms of autophagy in various diseases require more investigation. The application of autophagy inhibitors and activators will help us understand the regulation of autophagy in human diseases, and provide insight into the use of autophagy-targeted drugs. In this review, we summarize the latest research on autophagy inhibitors and activators and discuss the possibility of their application in human disease therapy.

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Section: Therapeutic Implications For Autophagy Regulatorsmentioning

confidence: 99%

Application and interpretation of current autophagy inhibitors and activators

et al. 2013

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“…Therefore methods to reduce oxidant-induced injury are important steps toward controlling hemorrhage-induced tissue damage. The antioxidant resveratrol (RSV) has been successfully used to reduce oxidative damage and inflammation in animal models of several human diseases (16).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1

Jian

Yang

Chaudry

et al. 2011

Mol Med

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Mitochondria play a critical role in metabolic homeostasis of a cell. Our recent studies, based on the reported interrelationship between c-Myc and Sirt1 (mammalian orthologue of yeast sir2 [silent information regulator 2]) expression and their role in mitochondrial biogenesis and function, demonstrated a significant downregulation of Sirt1 protein expression and an upregulation of c-Myc following trauma-hemorrhage (T-H). Activators of Sirt1 are known to improve mitochondrial function and the naturally occurring polyphenol resveratrol (RSV) has been shown to significantly increase Sirt1 activity by increasing its affinity to both NAD+ and the acetylated substrate. In this study we tested the salutary effect of RSV following T-H and its influence on Sirt1 expression. Rats were subjected to T-H or sham operation. RSV (8 mg/kg body weight, intravenously) or vehicle was administered 10 min after the onset of resuscitation, and the rats were killed 2 h following resuscitation. Sirtinol, a Sirt1 inhibitor, was administered 5 min prior to RSV administration. Cardiac contractility (±dP/dt) was measured and heart tissue was tested for Sirt1, Pgc-1α, c-Myc, cytosolic cytochrome C expression and ATP level. Left ventricular function, after T-H, was improved (P < 0.05) following RSV treatment, with significantly elevated expression of Sirt1 (P < 0.05) and Pgc-1α (P < 0.05), and decreased c-Myc (P < 0.05). We also observed significantly higher cardiac ATP content, declined cytosolic cytochrome C and decreased plasma tumor necrosis factor-α in the T-H-RSV group. The salutary effect due to RSV was abolished by sirtinol, indicating a Sirt1-mediated effect. We conclude that RSV may be a useful adjunct to resuscitation fluid following T-H.

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“…Most recently, resveratrol has been of interest because of its various favorable pharmacological effects of improving longevity (Howitz et al 2003, Picard et al 2004, Milne et al 2007. Accumulating evidence suggests that resveratrol has the potential to prevent obesity, diabetes, cardiovascular diseases, and a variety of human diseases (Szkudelska & Szkudelski 2010, Petrovski et al 2011. Several mechanisms, such as activation of Sirt1 or AMPK, have also been proposed to explain these effects of resveratrol (Turan et al 2012); however, the impact of resveratrol on 11b-HSD1 in adipose tissue has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…It is commonly found in fresh grape skins, red wine (pinot noir), boiled peanuts, and blueberries (dry sample) at 5-10 mg/100 g, 10.5 mg/l, 0.52 mg/100 g, and 0.4 mg/100 g respectively (Chachay et al 2011). As an ingredient of red wine, resveratrol explains the epidemiological phenomenon called the 'French paradox', in which red wine consumption is associated with a low incidence of cardiovascular disease (Petrovski et al 2011, Smoliga et al 2011, Turan et al 2012. In recent years, resveratrol has been shown to Structures of resveratrol (A), 17b-estradiol (B), 2-(4-hydroxyphenyl)-5-benzofuranol (C), and 2-(4-hydroxyphenyl)-6-benzofuranol (D).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes

Tagawa¹,

Kubota²,

Kato³

et al. 2013

Journal of Endocrinology

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It has been suggested that resveratrol, a polyphenol in wine, can regulate adiposity because it decreases adipose deposition in mice and rats; however, the mechanism underlying this effect has not been fully clarified. In humans and rodents, 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) is expressed in liver and adipose tissue. 11b-HSD1 converts inactive glucocorticoid into active glucocorticoid in adipocytes. Activated glucocorticoid plays an important role in the pathogenesis of central obesity. The objective of this study was to investigate the effects of resveratrol on 11b-HSD1 activity in rodent adipose tissue. 11b-HSD1 activity in microsomes from rat mesenteric adipose depots and 3T3-L1 adipocytes was determined in the presence of 11-dehydrocorticosterone with or without varying concentrations of resveratrol. Significant inhibition of 11b-HSD1 by resveratrol was observed in rat adipose microsomes and 3T3-L1 adipocytes within 10 min. Time-and dose-dependent effects were also observed. The 11b-HSD1 activity by resveratrol was also inhibited in rat epididymal adipose tissue, and this inhibition was not recovered by estrogen receptor blockers. The kinetic study revealed that resveratrol acted as a non-competitive inhibitor of 11b-HSD1. K i and IC 50 values of resveratrol were 39.6 and 35.2 mM respectively. Further, resveratrol did not affect the activities of 11b-HSD2 and hexose-6-phosphate dehydrogenase. These results suggest that the most likely mechanism of 11b-HSD1 inhibition by resveratrol is via interaction between resveratrol and 11b-HSD1 enzyme, rather than via a transcriptional pathway. We demonstrated that the antiobesity effects of resveratrol may partially be attributed to the inhibition of 11b-HSD1 activity in adipocytes.

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Resveratrol in cardiovascular health and disease

Cited by 211 publications

References 90 publications

Application and interpretation of current autophagy inhibitors and activators

Application and interpretation of current autophagy inhibitors and activators

Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose microsomes

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