Alcohol Dehydrogenase in Ethanol Metabolism

Wartburg, J. P. von; Papenberg, J.

doi:10.1097/00006842-196607000-00018

Cited by 27 publications

(3 citation statements)

References 5 publications

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“…Aus Rhesusaffenleber sind zwei Isoenzyme der ADH isoliert worden, welche sich in Bezug auf verschiedene physikalisch-chemische und katalytische Parameter unterscheiden [12,27]. Multiple molekulare Formen der ADH sind ferner bei Drosophila melanogaster [6,18], von Pflanzen [14,17] nachgewiesen Hefe [10,15] …”

Section: Heterogeneity and Tissue Distribution Of Alcohol Dehydrogenaunclassified

Heterogenität und Organverteilung der Alkoholdehydrogenase bei verschiedenen Spezies

Moser

Papenberg

Wartburg³

1968

Enzymol Biol Clin

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1. Alkoholdehydrogenase (ADH) wurde in verschiedenen Organen von zwölf Spezies untersucht. Das Enzym ist hauptsächlich in der Leber lokalisiert ; geringere Aktivitäten finden sich im Gastrointestinaltrakt, sowie in Niere und Lunge. Grosse Speziesunterschiede bestehen hinsichtlich Organverteilung der extrahepatischen ADH-Aktivität. 2. Bei sechs Spezies ist eine Heterogenität des Leberenzyms zu beobachten. Die Anzahl der Isoenzym-Banden ist je nach Spezies verschieden. 3. Aktivität und Isoenzymmuster der Leber-ADH zeigen beim Menschen eine beträchtliche individuelle Variabilität.

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Section: Heterogeneity and Tissue Distribution Of Alcohol Dehydrogenaunclassified

Heterogenität und Organverteilung der Alkoholdehydrogenase bei verschiedenen Spezies

Moser

Papenberg

Wartburg³

1968

Enzymol Biol Clin

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“…Although low concentration of alcohol stimulates the activity of hepatic ADH, high concentration of alcohol inhibits it [15]. In this study, a high dose (0.15 mL/100 mg) of Hongxing liquor (containing 65% ethanol) Pretreatment with ECR suppressed the inhibitory effect of high alcohol content on hepatic ADH activity (Fig 2A).…”

Section: Effect Of Ecr On Hepatic Adh and Aldh Activitiesmentioning

confidence: 49%

Effect of <i>Elaeagnus Conferta</i> Roxb (Elaeagnaceae) Dry Fruit on the Activities of Hepatic Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Mice

Wu¹,

Dai²,

Bai³

et al. 2011

Trop. J. Pharm Res

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Purposes: To determine the effect of Elaeagnus conferta Roxb dry fruit powder (ECR) on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Methods:In a randomized controlled study, acute alcohol intoxication was induced in mice with Hongxing liquor containing 65 % v/v ethanol orally. The effect of ECR on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in the mice was then investigated. Results: A 30-min pretreatment with ECR at 400 and 800 mg/kg led to a faster clearance of blood alcohol after the alcohol ingestion. The concentration of blood alcohol at 4 h after alcohol ingestion decreased by 21.2 % in mice pretreated with 800 mg/kg ECR. The activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were enhanced by ECR. Conclusion: These results suggest that pretreatment with ECR might stimulate the clearance of blood alcohol by increasing the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase.

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“…An interpretation of this result has to be tentative, but it may be sought in the fact that wild rats, in contrast to domestic rats, have large adrenal 320 glands. The adrenal glands generate adrenal-cortical steroids, one of which is alcohol dehydrogenase (ADH), which oxidizes alcohol in the liver (von Wartburg & Papenberg, 1966). It is conceivable that during the exposure phase of the experiment, alcohol ingestion in the wild rats was limited only by their liquid requirement, and that these animals, due to the size of their adrenal glands, are capable of metabolizing ethanol at a higher rate than domestic rats could.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption in domestic and wild rats

Eimer

Senter

1968

Psychon Sci

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Experimental attempts to establish in laboratory rats a behavior pattern analogous to human alcoholism have generally reaped negative results. Temporary increases in alcohol consumption have been achieved repeatedly (Senter & Sinclair, 1967;Senter, Smith, & Lewin, 1967;Myers, 1966), but the establishment of chroniC, autonomous, maladaptive alcohol consumption is so rare that McConnell & Clay (1963) have questioned whether mammals lower than man are susceptible to the development of such behavior patterns. An exception to this trend has been reported by Richter (1957). While this researcher reported repeated failure to addict domestic laboratory rats, he succeeded in "addicting two fierce, aggressive wild rats trapped from the streets. This was done by restricting fluid intakes to a 20% solution of alcohol over a period of six months. When given a choice of food, water and a 20% solution of alcohol, these rats gradually ate less food, drank less plain water, and more alcohol. As a result they progressively lost weight and finally died" (p. 218). The present research was undertaken to investigate more systematically the observation made by Richter. MethodTwenty wild pack rats (Genus Neotoma), captured in Arizona, and 16 domestic hooded rats were continuously exposed to standard laboratory rat chow and a 20% (V IV) alcohol solution for 20 weeks. Subsequent to this exposure period, both groups were given rat chow, a 20% alcohol solution, and water for nine weeks. Consumption of alcohol solution was recorded daily throughout the 20 week exposure period and the nine week choice period. Weekly mean consumption of alcohol solution in ml for each S was established for data analysis.

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Alcohol Dehydrogenase in Ethanol Metabolism

Cited by 27 publications

References 5 publications

Heterogenität und Organverteilung der Alkoholdehydrogenase bei verschiedenen Spezies

Heterogenität und Organverteilung der Alkoholdehydrogenase bei verschiedenen Spezies

Effect of <i>Elaeagnus Conferta</i> Roxb (Elaeagnaceae) Dry Fruit on the Activities of Hepatic Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Mice

Alcohol consumption in domestic and wild rats

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