Alcohol Consumption Is a Risk Factor for Colonic Diverticulosis

Sharara, Ala I.; El-Halabi, Mustapha; Mansour, Nabil; Malli, Ahmad; Ghaith, Ola; Hashash, Jana G.; Maasri, Karim; Soweid, Assaad; Barada, Kassem; Mourad, Fadi H.; Zahabi, Lara El

doi:10.1097/mcg.0b013e31826be847

Cited by 50 publications

(44 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that Asians and blacks, including those from the Caribbean, were protected against left-sided diverticular disease compared to whites, with the odds ratio of left- The prevalence of diverticulosis has been estimated prospectively in several colonoscopy-based studies in Asia. The prevalence of diverticulosis in Lebanon was similar to that in the United States [12]; that is, the rate was 33% (mean age: 61 years), and most subjects had distal diverticulosis. However, other studies from the Middle East suggest a much lower prevalence.…”

Section: Diverticulosismentioning

confidence: 71%

See 1 more Smart Citation

The Burden of Diverticular Disease and Its Complications: West versus East

Imaeda¹,

Hibi²

2018

Inflamm Intest Dis

View full text Add to dashboard Cite

Background: Colonic diverticulosis is prevalent and increasing not only in Western but also in Asian countries. Diverticulosis can be complicated by diverticulitis and diverticular bleeding. Diverticular disease is a burdensome digestive disease, because it is a major cause of hospital admissions and is associated with significant health-care costs. Summary: The incidence of diverticulosis increases with age. Most cases of diverticulosis in Western countries involve the left side of the colon, while diverticulosis is predominantly present on the right side of the colon in Asian countries. The incidence of diverticulitis also increases with age. Diverticulitis is predominantly located on the left side of the colon in Western countries, while it is predominantly located on the right side of the colon in Asian countries. The overall complication rate is higher in left-sided than in right-sided diverticulitis. The incidence of diverticular bleeding also increases with age. The right colon is the source of diverticular bleeding in more than 50% of patients in Western countries. In Asian countries, age greater than 70 years and both-sided diverticulosis increase the bleeding risk. Key Messages: In Western countries, diverticulosis and diverticulitis are predominantly located on the left side of the colon, whereas they are predominantly present on the right side of the colon in Asian countries. Diverticular bleeding is predominantly located on the right side in Western countries, and both-sided diverticulosis increases the risk of bleeding in Asian countries. Diverticular disease with complications requires admission and operation; moreover, it recurs frequently. Therefore, diverticular disease is associated with a significant economic burden in terms of health-care costs and resource utilization.

show abstract

Section: Diverticulosismentioning

confidence: 71%

“…The changing frequency of the bilateral type, with respect to both year and age, was similar to that of the left-sided type. In Asian countries, right-sided diverticulosis is thought to be of congenital origin, and diverticula developing subsequently on the left may extend into the bilateral colon [12,17].…”

Section: Diverticulosismentioning

confidence: 99%

The Burden of Diverticular Disease and Its Complications: West versus East

Imaeda¹,

Hibi²

2018

Inflamm Intest Dis

View full text Add to dashboard Cite

show abstract

“…However, as mentioned earlier, the prevalence is much lower in Africa and parts of Asia. The explanation for this East-West paradox in disease prevalence and phenotype is unclear but it has been suggested to be due to diet, particularly a high-fat diet, and alcohol consumption may also play a role in disease pathogenesis [8][9][10].…”

Section: Epidemiologymentioning

confidence: 99%

“…In the West, it is estimated that around 15-30% of the individuals will have diverticulosis by the age of 50 years [3] and as many as 60-70% by the age of 80 years [3,4], primarily located in the left colon. The prevalence is much lower in less industrialized parts of the world, such as Africa and parts of Asia, where it is found in only 4-5% of the population, with a pre-DOI: 10.1159/000490054 dominance of right-sided disease in Asian populations [5,6]. Recent evidence indicates that this prevalence is expected to further increase worldwide, possibly due to urbanization and the adoption of western lifestyles [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Natural History of Colonic Diverticulosis: Much Ado about Nothing?

Rustom

Sharara²

2018

Inflamm Intest Dis

View full text Add to dashboard Cite

Background: Colonic diverticulosis is the most common incidental lesion found on routine colonoscopy. However, its true natural history is unclear. The aim of this review is to examine the epidemiology of colonic diverticulosis and the incidence of complications, namely acute diverticulitis and diverticular hemorrhage. Summary: Many studies have evaluated the epidemiology and risk factors of diverticulosis. Despite the common nature of this entity, little is known about the risk of complications in asymptomatic individuals. It has been suggested that the lifetime risk of acute diverticulitis is 10–25% and that of diverticular hemorrhage is 3–5%. These risk estimates were based on older literature without accurate studies on true prevalence. Three recent retrospective observational cohort studies including subjects identified at colonoscopy have addressed this issue, providing information on the long-term risk of complications of colonic diverticulosis. Cumulative data from these studies support an incidence of acute diverticulitis of 1.5–6.0 per 1,000 patient-years and 0.46 per 1,000 patient-years for diverticular hemorrhage. Key Messages: Diverticulosis is a very common condition in individuals > 50 years of age. Based on population-based colonoscopy studies, the natural history of colonic diverticulosis appears favorable with a far lower incidence of complications than previously thought.

show abstract