Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study

Laguzzi, Federica; Baldassarre, Damiano; Veglia, Fabrizio; Strawbridge, Rona J.; Humphries, Steve E.; Rauramaa, Rainer; Smit, Andries J.; Giral, Philippe; Silveira, Angela; Tremoli, Elena; Hamsten, Anders; Fairé, Ulf dé; Frumento, Paolo; Leander, Karin

doi:10.1007/s00394-020-02220-5

Cited by 14 publications

(20 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our study, high alcohol consumption is associated with increased cIMT 34 . But other studies noted that a relatively lower dose of alcohol consumption was protective for cardiovascular health 35,36 . We did not find significant correlations for obesity index, but another follow‐up study found baseline BMI associated with cIMT progression just in men 25 .…”

Section: Discussionsupporting

confidence: 89%

Sex‐specific risk factors of carotid atherosclerosis progression in a high‐risk population of cardiovascular disease

Cheng

Zhou

Wang

et al. 2022

Clinical Cardiology

View full text Add to dashboard Cite

Background The progression of carotid intima‐media thickness (cIMT) and plaques are associated with cardiovascular health, especially for high‐risk population of cardiovascular disease (CVD). Hypothesis Risk factors for atherosclerosis may vary by sex. This study aimed to investigate the sex‐specific risk factors of cIMT and plaque progression. Methods We selected subjects who were identified as high‐risk population of CVD, and collected their carotid ultrasound data and baseline characteristics. Linear regression and logistic regression analyses were used to identify risk factors for cIMT and plaque progression. Sex‐specific risk factors were identified respectively. Results A total of 7908 participants were included. The mean age was 57.75 ± 9.45 years and 61.51% were female. During mean follow‐up of 1.92 ± 0.89 years, the median annual cIMT change rate was −7.25 μm/year. Seven hundred and fifteen subjects free from plaques at baseline developed plaque. Age, smoking, hypertension, and diabetes were common risk factors for carotid atherosclerosis progression in all participants. Smoking and alcohol drinking were significantly associated with increased cIMT change in women, while hypertension and antihypertensive medication were significant in men. Increased total cholesterol and diabetes were significantly associated with new plaque presence in women, while smoking, increased triglyceride, and dyslipidemia were significant in men ( p ˂ .05 for all cases). The association of baseline cIMT and smoking with annual cIMT change rate and increased total cholesterol with new plaque presence were significantly differentiated between both sexes ( p for interaction ˂ .05). Conclusions The risk factors for cIMT and plaque progression differed by sex.

show abstract

Section: Discussionsupporting

confidence: 89%

Sex‐specific risk factors of carotid atherosclerosis progression in a high‐risk population of cardiovascular disease

Cheng

Zhou

Wang

et al. 2022

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…Although the relationship between alcohol consumption and atherosclerosis has not been well established, moderate alcohol consumption reduced the severity of atherosclerosis and the risk of heart failure [19,20]. However, our findings showed that prolonged alcohol consumption increased the risk of atherosclerosis in the infrainguinal muscular arteries.…”

Section: Discussioncontrasting

confidence: 55%

Lupus Anticoagulant and Anticardiolipin Antibody IgG are Associated with Increased Atherosclerosis at the Suprainguinal Elastic and Infrainguinal Muscular Arteries in the Abdomen and Lower Extremities

Park

2022

Artery Res

View full text Add to dashboard Cite

Purpose Whether antiphospholipid antibodies (aPLs) cause atherosclerosis in certain arteries with specific compositions and locations remains unknown. We investigated the relationship between aPLs and their association with locations of atherosclerosis in the arteries of the abdomen and lower extremities. Methods Of 2273 patients, 697 who underwent computed tomography angiography of the abdomen and lower extremities and aPL evaluation were included. Atherosclerosis distribution score (ADS) was employed to quantify atherosclerosis severity. Multiple linear regression analysis was performed using the ADS of the suprainguinal elastic and infrainguinal muscular arteries as dependent variables and all aPLs, conventional risk factors of atherosclerosis, and coagulation-related factors as independent variables. Results In the suprainguinal elastic and infrainguinal muscular arteries, common risk factors for higher ADS were age, smoking, hypertension, higher glycated hemoglobin, male sex, decreased protein S, and increased homocysteine. Lupus anticoagulant (LA) and increased triglyceride level in the suprainguinal elastic arteries and anticardiolipin antibody (aCL) immunoglobulin (Ig)G, longer alcohol consumption duration, and increased fibrinogen level in the infrainguinal muscular arteries were also risk factors for higher ADS. Conclusion LA and aCL IgG were associated with atherosclerosis in the suprainguinal elastic and infrainguinal muscular arteries, respectively. aPLs could predict the location of atherosclerosis.

show abstract

“…Moreover, a U-shaped and J-shaped association between alcohol consumption and atherosclerosis and subclinical atherosclerotic damage and progression (such as carotid intima media thickness measurements) was confirmed in many epidemiological observations and in several populations also heterogeneous from a CV risk perspective [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 87%

Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Background: Arterial stiffness as assessed by Pulse Wave Velocity (PWV) represents an independent predictor of cardiovascular disease. Several dietary compounds and lifestyle factors could influence arterial stiffness. The debate on the significance of the correlation between alcohol consumption and arterial stiffness is still open, given that the relationship is complex and potentially affected by several factors such as alcohol type, consumption levels, gender and age differences. Objective: This systematic literature review aims to examine the evidence supporting an association between alcohol use and PWV, in electronic databases including PubMed/MEDLINE and the Cochrane Library, from January 2010 to November 2020. Screening and full-text reviews were performed by three investigators and data extraction by two. Considering the significant heterogeneity of data only a qualitative analysis (systematic review) was performed. Results: A total of 13 studies met the inclusion criteria. Alcohol consumption was independently associated with arterial stiffness in a J-shaped way in most of the studies included. A benefit of alcohol consumption on arterial stiffness was found in four experimental studies, whilst an unfavorable increasing linear association was found in four others. Associations were confirmed with both oscillometric and tonometric PWV assessment methods. In some studies, a gender and age correlation was found with a more pronounced association in older males. In all studies elevated levels of alcohol consumption were associated with a worsening of arterial stiffness. Conclusions: Despite the variable findings across studies, the current review provides preliminary evidence that light-to-moderate alcohol consumption is associated with arterial stiffness values lower than expected, and evidence that high doses accelerate arterial ageing. These findings could be useful for clinicians who provide recommendations for patients at cardiovascular (CV) risk. Nevertheless, given the heterogeneity of study designs, interventions, measurement methods and statistical evaluations, the protective role of moderate alcohol consumption on arterial stiffness is likely but not certain, warranting additional trials and evidence.

show abstract

Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study

Cited by 14 publications

References 51 publications

Sex‐specific risk factors of carotid atherosclerosis progression in a high‐risk population of cardiovascular disease

Sex‐specific risk factors of carotid atherosclerosis progression in a high‐risk population of cardiovascular disease

Lupus Anticoagulant and Anticardiolipin Antibody IgG are Associated with Increased Atherosclerosis at the Suprainguinal Elastic and Infrainguinal Muscular Arteries in the Abdomen and Lower Extremities

Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review

Contact Info

Product

Resources

About