Alcohol consumption during pregnancy and the risk of early stillbirth among singletons

Aliyu, Muktar H.; Wilson, Roneé E.; Zoorob, Roger; Chakrabarty, Sangita; Alio, Amina P.; Kirby, Russell S.; Salihu, Hamisu M.

doi:10.1016/j.alcohol.2008.04.003

Cited by 64 publications

(39 citation statements)

References 39 publications

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“…Hazard ratio was 1.55 among women in the Danish National Birth Cohort who reported binge drinking three or more times during pregnancy [23]. An odds ratio of 1.4 for stillbirth was also found in a cohort of 3,508 singleton pregnancies in Missouri, which increased to 1.7 in women consuming five or more drinks per week [24]. …”

Section: Effects On the Developing Embryo And Fetusmentioning

confidence: 99%

Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Ornoy

Ergaz

2010

IJERPH

148

109

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Offspring of mothers using ethanol during pregnancy are known to suffer from developmental delays and/or a variety of behavioral changes. Ethanol, may affect the developing fetus in a dose dependent manner. With very high repetitive doses there is a 6–10% chance of the fetus developing the fetal alcoholic syndrome manifested by prenatal and postnatal growth deficiency, specific craniofacial dysmorphic features, mental retardation, behavioral changes and a variety of major anomalies. With lower repetitive doses there is a risk of “alcoholic effects” mainly manifested by slight intellectual impairment, growth disturbances and behavioral changes. Binge drinking may impose some danger of slight intellectual deficiency. It is advised to offer maternal abstinence programs prior to pregnancy, but they may also be initiated during pregnancy with accompanying close medical care. The long term intellectual outcome of children born to ethanol dependent mothers is influenced to a large extent by the environment in which the exposed child is raised.

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Section: Effects On the Developing Embryo And Fetusmentioning

confidence: 99%

Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Ornoy

Ergaz

2010

IJERPH

148

109

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“…Unfortunately, during the 3 rd and 4 th weeks of pregnancy, when gastrulation and neurulation respectively occur, the developing embryo is particularly vulnerable to ethanol insult, as documented in an autopsy study (Coulter et al, 1993). Additionally, such early ethanol exposure may increase the risk of spontaneous abortions or prematurity (Jaddoe et al, 2007; Sokol et al, 2007; Aliyu et al, 2008; O’Leary et al, 2009; Meyer-Leu et al, 2011; Andersen et al, 2012; Chiodo et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Low and moderate prenatal ethanol exposures of mice during gastrulation or neurulation delays neurobehavioral development

Schambra

Goldsmith

Nunley

et al. 2015

Neurotoxicology and Teratology

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Human and animal studies show significant delays in neurobehavioral development in offspring after prolonged prenatal exposure to moderate and high ethanol doses resulting in high blood alcohol concentration (BECs). However, none have investigated the effects of lower ethanol doses given acutely during specific developmental time periods. Here, we sought to create a mouse model for modest and circumscribed human drinking during the 3rd and 4th weeks of pregnancy. We acutely treated mice during embryo gastrulation on gestational day (GD) 7 or neurulation on GD8 with a low or moderate ethanol dose given via gavage that resulted in BECs of 107 and 177 mg/dl, respectively. We assessed neonatal physical development (pinnae unfolding, and eye opening); weight gain from postnatal day (PD) 3-65; and neurobehavioral maturation (pivoting, walking, cliff aversion, surface righting, vertical screen grasp, and rope balance) from PD3-17. We used a multiple linear regression model to determine the effects of dose, sex, day of treatment and birth in animals dosed during gastrulation or neurulation, relative to their vehicle controls. We found that ethanol exposure during both time points (GD7 and GD8) resulted in some delays of physical development and significant sensorimotor delays of pivoting, walking, and thick rope balance, as well as additional significant delays in cliff aversion and surface righting after GD8 treatment. We also found that treatment with the low ethanol dose more frequently affected neurobehavioral development of the surviving pups than treatment with the moderate ethanol dose, possibly due to a loss of severely affected offspring. Finally, mice born prematurely were delayed in their physical and sensorimotor development. Importantly, we showed that brief exposure to low dose ethanol, if administered during vulnerable periods of neuroanatomical development, results in significant neurobehavioral delays in neonatal mice. We thus expand concerns about alcohol consumption during the 3rd and 4th week of human pregnancy to include occasional light to moderate drinking.

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“…Methodological or design limitations or weaknesses, such as small sample size, failure to control adequately for potential confounding factors, or inadequate assessment of alcohol exposure and/or gestational age, may explain why no significant link between exposure and preterm birth was identified in some studies (Bailey & Sokol, 2008a). However, other methodologically sound, well-controlled studies have identified an increased risk of both stillbirth and preterm delivery among women who consume alcohol during pregnancy (Adams et al, 1995; Aliyu et al, 2008b; Bailey & Sokol, 2008a; Kesmodal et al, 2002b; Sokol et al, 2007). …”

Section: Introductionmentioning

confidence: 99%

“…There is evidence for increased risk for SAb with obesity or high body mass index (BMI; ASRM, 2008; Jarvie & Ramsay, 2010). Maternal alcohol consumption during pregnancy has been examined as another potential risk factor for SAb (e.g., Abel, 1997; Aliyu et al, 2008b; Henderson et al, 2007a; 2007b; Kesmodel et al, 2002a; 200b). Early research suggested that heavy drinking during pregnancy was associated with a significantly increased rate of SAb (Sokol, 1980).…”

Section: Introductionmentioning

confidence: 99%

Recognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use

Chiodo

Bailey

Sokol

et al. 2012

Alcohol

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Alcohol consumption during pregnancy is one potential risk factor for spontaneous abortion (SAb). Prior research suggested that heavy drinking during pregnancy was associated with significantly increased rates of SAb, but results for lower levels of drinking have been inconsistent. We examined the association between different levels and patterns of prenatal alcohol consumption and SAb in a high-risk inner-city sample. We hypothesized that higher levels, binge patterns, and more frequent drinking would be associated with increased rates of SAb. The quantity and frequency of self-reported peri-conceptional and repeated in-pregnancy maternal drinking volumes per beverage type were assessed with semi-structured interviews in a prospective subsample of 302 African-American mothers. Relations between various measures of prenatal alcohol exposure and SAb were assessed using logistic regression. After controlling for various potential confounders, there was a significant positive relation between average absolute alcohol use per day across pregnancy and SAb. Greater frequency of drinking episodes also predicted SAb: an average of even one day of drinking per week across pregnancy was associated with an increase in the incidence of SAb. However, contrary to our hypothesis, neither the amount of alcohol drunk per drinking day nor a measure of binge drinking were significantly related to SAb after controlling for confounders. Differences in when women who drank at risk levels initiated antenatal care may have under-estimated the impact of alcohol on SAb in this low-SES urban African American sample. Some drinking measures averaged across pregnancy may have underestimated consumption and overestimated risk of SAb, but others risk-drinking measures that avoid this limitation show similar relations to SAb. Identifying fetal risk drinking in pregnant women is critical to increasing the effectiveness of interventions that reduce risk-level alcohol consumption and protect from pregnancy loss.

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Alcohol consumption during pregnancy and the risk of early stillbirth among singletons

Cited by 64 publications

References 39 publications

Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Low and moderate prenatal ethanol exposures of mice during gastrulation or neurulation delays neurobehavioral development

Recognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use

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