Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Ornoy, Asher; Ergaz, Zivanit

doi:10.3390/ijerph7020364

Cited by 148 publications

(120 citation statements)

References 74 publications

(86 reference statements)

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“…In this regard, HED is noteworthy because it can expose the developing fetus to relatively high blood alcohol concentrations over short periods, with resulting increased risk of adverse pregnancy outcomes (Goodlett & Horn, 2001;Ornoy & Ergaz, 2010). To the extent that adverse effects of alcohol drinking during pregnancy actually vary across months of the same trimester, the monthly approach of this study might stimulate new research.…”

Section: Discussionmentioning

confidence: 99%

Monthly Estimates of Alcohol Drinking During Pregnancy: United States, 2002–2011

Alshaarawy

Breslau

Anthony

2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Taking a step beyond prior alcohol research on pregnancy trimesters, we produced pregnancy month-specific drinking estimates for women in the United States in order to shed light on time variations of alcohol drinking during pregnancy, as might be determined by alcohol dependence. We posited that (a) pregnancy might prompt cessation of drinking soon after pregnancy status is discovered, a finding obscured in trimester-specific estimates, and (b) a possible alcoholdependence effect on drinking persistence among pregnant women might be observed via the monthly approach. Method: Data are from the 2002-2011 National Surveys on Drug Use and Health (Restricted-Data Analysis System [R-DAS]), with large nationally representative samples of U.S. civilians, including 12-to 44-year-old females stratified by pregnancy status and month of pregnancy, and with assessment of recent alcohol dependence as well as heavy episodic drinking (HED). Results: Pregnancy's possibly protective constraints on drinking can be seen as early as Month 2. We observed considerable variability of drinking prevalence (%) before Trimester 1 ended, with no appreciable variation across Months 4-9. A possible alcohol-dependence effect on drinking persistence is seen when the contrast is made in relation to expected values for pregnant women without alcohol dependence. Conclusions: We detected a possibly ameliorative pregnancy effect on alcohol use and HED, with variation in drinking prevalence across the months of the first trimester. Alcohol dependence might be affecting drinking persistence among pregnant women, but this effect cannot account for the drinking persistence observed here. (J. Stud. Alcohol Drugs, 77, 272-276, 2016)

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Section: Discussionmentioning

confidence: 99%

Monthly Estimates of Alcohol Drinking During Pregnancy: United States, 2002–2011

Alshaarawy

Breslau

Anthony

2016

J. Stud. Alcohol Drugs

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“…Fetal exposure to alcohol has been associated with an increased risk of both fetal growth restriction and alcoholism in the offspring (Ornoy and Ergaz, 2010). Although we do not have specifi c information regarding the mothers' alcohol use during pregnancy, the level of alcohol use by Danish women in general during this historical time frame is estimated to be very low.…”

Section: Study Limitationsmentioning

confidence: 94%

Effects of Premature Birth on the Risk for Alcoholism Appear to Be Greater in Males Than Females

Manzardo¹,

Madarasz²,

Penick³

et al. 2011

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Method: Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive series of measures was obtained for each of the 8,109 surviving and eligible infants before birth, during birth, shortly after birth, and at 1 year. The adult alcoholism outcome was defi ned as any ICD-10 F10 diagnosis (Mental and behavioral disorders due to alcohol use) or an equivalent ICD-8 diagnosis found in the Danish Psychiatric Central Research Register or the Municipal Alcohol Clinics of Copenhagen by 2007. Results: Multiple perinatal markers of premature birth independently predicted the development of an alcoholism diagnosis in male (n = 310) but not female (n = 138) subjects. Logistic regression modeling with a global prematurity score, adjusted for social status, maternal smoking, and gender, indicated a signifi cant association of prematurity score for males (p < .02), but not females (p = .51), on the risk of developing an alcohol use disorder. Conclusions: The results suggest that neurodevelopmental sequelae of premature birth are associated with gender-specifi c effects on the development of alcoholism in the male baby: small, premature, or growth-delayed male babies appear to be selectively vulnerable to alcoholic drinking years later. The fi ndings implicate neurodevelopmental infl uences in alcoholism pathophysiology in males and suggest the possibility of distinct, gender-specifi c pathways in the etiology of severe problem drinking. (J. Stud. Alcohol Drugs, 72,

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“…For example, malnutrition can reduce IGF-I level, which results impaired growth (Matera and Rapaport, 2002). Poor social environment and related alcohol consumption can both induce retardation in body growth and development (Ornoy and Ergaz, 2010), increased estradiol and reduce testosterone level in blood (Gavaler and Van Thiel, 1992).…”

Section: Possible Interactions Between Several Observed Indexes and Tmentioning

confidence: 99%

Growth and obesity and its association with plasma level of steroid hormones and insulin-like growth factor-I (IGF-I) in Slovak female students

Zatko¹,

Matejovičová²,

Boledovicova³

et al. 2013

BLL

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Abstract:The aim of the present study was to examine the possible role of steroid hormones and insulin-like growth factor 1 (IGF-I) in the control of human growth and obesity. We measured plasma level of progesterone, testosterone, estradiol and IGF-I in 301 young women at different stages of their ovarian cycle, and compared them to the standard morphometric indexes of their growth and obesity -body height, body weight, abdomen circumstance and waist to hip ratio (WHR). The ovarian cycle-dependent changes in plasma progesterone and estradiol, but not in testosterone and IGF-I level were found. Young women with higher body height had significantly higher plasma level of estradiol, testosterone and IGF-I, but not of progesterone, compared to subjects with lower body height in both follicular and luteal phases of the ovarian cycle. Subjects with a higher body weight had signifi cantly higher plasma estradiol and progesterone, but not testosterone and IGF-I than subjects with lower body weight in both follicular and luteal phases of ovarian cycle. Women with a higher abdomen circumference had signifi cantly lower plasma estradiol, but not the other hormones than the subjects with lower abdomen circumference. Women with higher WHR index had signifi cantly higher plasma level of estradiol, but not other hormones than subjects with lower WHR index in both follicular and luteal phases of ovarian cycle. The present observations suggests: (1) that luteal phase of the women ovarian cycle is characterised by a dramatically increase in both progesterone and estradiol, but not in testosterone and IGF-I release, (2) that in human females growth can be up-regulated by testosterone, estradiol and IGF-I, but not by progesterone, (3) that body mass can be up-regulated by progesterone and estradiol, but not by testosterone or IGF-I, and (4) that women obesity (high WHR, but not abdomen circumference) can be promoted by estradiol, but not by other steroid hormones or Fig. 4, Ref. 45). Full Text in PDF www.elis.sk.

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Alcohol Abuse in Pregnant Women: Effects on the Fetus and Newborn, Mode of Action and Maternal Treatment

Cited by 148 publications

References 74 publications

Monthly Estimates of Alcohol Drinking During Pregnancy: United States, 2002–2011

Monthly Estimates of Alcohol Drinking During Pregnancy: United States, 2002–2011

Effects of Premature Birth on the Risk for Alcoholism Appear to Be Greater in Males Than Females

Growth and obesity and its association with plasma level of steroid hormones and insulin-like growth factor-I (IGF-I) in Slovak female students

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