Alcohol Consumption and Ovarian Cancer Risk

Gwinn, Marta; Webster, Linda A.; Lee, Nancy C.; Layde, Peter M.; Rubin, George

doi:10.1093/oxfordjournals.aje.a114304

Cited by 57 publications

(32 citation statements)

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“…We could not confirm the positive associations of either alcohol consumption (17,21) or coffee consumption (18) with ovarian cancer, which have been reported previously. Studies on the role of dietary fat have been inconclusive; one report showed a significant association (20) while another did not (19).…”

Section: Discussioncontrasting

confidence: 95%

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Reproductive, Genetic, and Dietary Risk Factors for Ovarian Cancer

Mori¹,

Hayashi²,

Miyake³

et al. 1988

American Journal of Epidemiology

164

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A case-control study of 110 women with ovarian epithelial carcinoma and 220 individually age-matched controls was conducted in Hokkaido, Japan, to identify ovarian cancer risk factors. Both the cases and the matched controls were surveyed either from 1980 to 1981 or from 1985 to 1986. Ovarian cancer risk was increased in single women (p less than 0.01), and in women with a family history of breast, uterine, or ovarian cancer in a mother or sister (p less than 0.001). Conversely, risk was decreased in women who had experienced a livebirth (p less than 0.001), an induced abortion (p less than 0.05), or who had had permanent sterilization by tubal ligation (p less than 0.05). Each of the reproductive factors remained significant when adjusted for each other using logistic regression analysis. The odds ratio for ovarian cancer decreased significantly with increasing number of livebirths (p less than 0.001). Furthermore, a significant negative association between anovulatory periods and ovarian cancer risk was noted (p less than 0.01). No association was observed for any types of contraceptive methods other than tubal ligation, but the prevalence of oral contraceptive use was very low. A significant positive association with daily fish consumption (p less than 0.05) and a marginally significant negative association with daily milk consumption (p = 0.05) were also observed.

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Section: Discussioncontrasting

confidence: 95%

“…We conducted a case-control study of ovarian cancer in Japan designed to evaluate reproductive (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), genetic (5,7,9,12,17), and dietary risk factors (17)(18)(19)(20)(21), all of which have been found to be associated with the occurrence of ovarian cancer in Western countries.…”

mentioning

confidence: 99%

Reproductive, Genetic, and Dietary Risk Factors for Ovarian Cancer

Mori¹,

Hayashi²,

Miyake³

et al. 1988

American Journal of Epidemiology

164

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“…That this association was limited to the period of time shortly before diagnosis suggests that it is related to growth rather than initiation of these tumours. Alcohol consumption has been reported as unassociated with epithelial ovarian cancer (Gwinn et al, 1986), and an association with testicular cancer has not been reported. Alcohol use may, however, increase the risk of breast cancer and other cancers (Schatzkin et al, 1987).…”

Section: Discussionmentioning

confidence: 98%

Benign ovarian teratomas: a population-based case-control study

Westhoff

Pike²,

Vessey³

1988

Br J Cancer

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Summary We attempted to identify all cases of benign ovarian teratoma which occurred in two health districts in the UK during a 56 month period. The crude incidence was 8.9 cases/100,000 women. One hundred and twenty cases and 119 age-matched controls were interviewed to identify risk factors for this disease. In addition, 137 mothers completed postal questionnaires. Cases were older at leaving school, had higher social class occupations, were more often unmarried or married late, and had fewer children than controls. Oral contraceptive use was similar for both. Cases reported more exercise at all ages, and more alcohol consumption 1 year before diagnosis. Cases' mothers reported slightly less nausea during pregnancy than controls' mothers, and none of the mothers reported exogenous hormone exposure during the index pregancy. In this study benign ovarian teratomas strongly resemble testicular cancer in their age distribution in the population. They also resemble testicular cancer in their association with educational status and marital status. There was, however, no similarity regarding prenatal hormone exposure. The increased risks associated with exercise and alcohol use were unexpected; we need further information about how these exposures affect the ovary, and whether they affect the testis.

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“…2,6,23 Bias related to control selection is a particular concern in hospital-based studies given that many diseases leading to hospitalization are also associated with alcohol use. Of population-based case-control studies, several suggested nonsignificant 5,14,24 or significant 16 protection, whereas the remainder were consistent with an increased risk 8 or no association. 11,15 Only 2 prospective studies have considered the association: null results were obtained in the Netherlands Cohort Study, 13 whereas the Iowa Women's Health Study indicated a statistically significant inverse trend with increasing intake.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and ovarian cancer risk in a population‐based case–control study

Trentham‐Dietz

Newcomb

Chen

et al. 2006

Intl Journal of Cancer

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Alcohol consumption has been investigated as a possible risk factor for ovarian cancer in several epidemiological studies, with inconsistent findings. Recent studies have suggested that the association between alcohol consumption and ovarian cancer may vary according to histologic subtype of ovarian cancer and type of alcohol consumed (e.g., wine, beer, or liquor). We examined these associations in a population-based case-control study comprised of 762 incident cases of epithelial ovarian cancer and 6,271 population controls from Massachusetts and Wisconsin aged 40-79 years. Women reported their usual alcohol consumption as young adults (20-30 years of age) and in the recent past. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. There was no significant association of ovarian cancer with increasing alcohol consumption either during ages 20-30 years (p trend 0.42) or in the recent past (p trend 0.83). Regular drinking of beer (1 drink/day or more) during ages 20-30 (OR 1.55, 95% CI 1.07-2.26), though not liquor (OR 1.35, 95% CI 0.86-2.11) or wine (OR 0.99, 95% CI 0.49-2.00), was associated with a statistically significant increase in risk of invasive tumors, whereas no significant relationships were observed for recent drinking, regardless of alcohol type. The elevated risk for early adult regular drinking was confined to serous invasive tumors (OR 1.52, 95% CI 1.01-2.30), though results for other subtypes were based on sparse data and results were imprecise. In this study, neither total alcohol consumption as a young adult nor recently was associated with an increase in the risk of ovarian cancer. ' 2006 Wiley-Liss, Inc.Key words: ovarian neoplasms; alcohol drinking; women; risk factorsThe etiology of ovarian cancer is poorly understood, and most established risk factors are related to reproduction. 1 Thus, there are limited opportunities for prevention of this often fatal cancer. Alcohol consumption, a common, potentially modifiable exposure, has been investigated as a possible cause of ovarian cancer in several epidemiological studies, with inconclusive findings. Many case-control studies have not shown a statistically significant association with alcohol consumption. 2-11 Of the 2 prospective cohort studies published, 1 found a statistically significant decreased risk with increasing alcohol consumption, 12 while the other 1 found no association. 13 Some recent studies have suggested that the association between alcohol consumption and ovarian cancer may vary by ovarian cancer histology [14][15][16] or by the type of alcohol consumed (e.g., wine, beer, or liquor). 14, 15 We evaluated these associations in a large population-based US casecontrol study in which we collected detailed information on alcohol consumption. Material and methods Study participants and designCases. Eligible women were enrolled in 2 case-control studies conducted in the populations of Massachusetts (excluding Boston) and Wisconsin. All English-speaking female residents, aged 40-79 (1993-1995) or aged 20-75 (1998-2...

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Alcohol Consumption and Ovarian Cancer Risk

Cited by 57 publications

References 0 publications

Reproductive, Genetic, and Dietary Risk Factors for Ovarian Cancer

Reproductive, Genetic, and Dietary Risk Factors for Ovarian Cancer

Benign ovarian teratomas: a population-based case-control study

Alcohol consumption and ovarian cancer risk in a population‐based case–control study

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