Alcohol Consumption and Micronutrient Intake as Risk Factors for Liver Cirrhosis: A Case-Control Study

Corrao, Giovanni; Torchio, Pierfederico; Zambon, Antonella; D'Amicis, A.; Lepore, Alberto; Orio, Ferdinando di

doi:10.1016/s1047-2797(97)00193-2

Cited by 32 publications

(15 citation statements)

References 35 publications

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“…7 Accumulation of fat in the liver tends to increase the sensitivity of the liver to the second hit that leads to inflammatory liver cell damage. 8 Oxidative stress, endotoxins, and cytokines are considered to be the causes of the second hit and are related to the pathogenesis of ALD. The therapy of ALD varies according to the severity of liver damage and clinical condition of an individual.…”

Section: Introductionmentioning

confidence: 99%

Study of antioxidant potential of malotilate in ethanol induced hepatic dysfunction in Sprague Dawley rats

Borole

Swami

Padalkar

2016

Int J Basic Clin Pharmacol

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Section: Introductionmentioning

confidence: 99%

Study of antioxidant potential of malotilate in ethanol induced hepatic dysfunction in Sprague Dawley rats

Borole

Swami

Padalkar

2016

Int J Basic Clin Pharmacol

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“…About 60%-89% of hepatocellular carcinoma is associated with underlying cirrhosis 26,28,54,56,[63][64][65] , while the prevalence of hepatocellular carcinoma complicating cirrhosis is between 2.2% and 73% 13,15,26,54,56,65 . Although chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection have been implicated as the major risk factors for cirrhosis 3,11,12,20,53,54,61,62 , some cirrhosis occurs in patients without serologic evidence of HBV/HCV infection 1,5,10,14,16,18,37,38,53,60 , suggesting that other viruses, environmental factors, or differences in lifestyle habits are also important. To prevent cirrhosis-associated mortality and morbidity, exploration of risk factors other than HBV/HCV is urgent.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic inflammation of the liver appears to be a risk factor for cirrhosis regardless of the underlying etiology 5,10,16,25,53,54,61,62 . Experimental study has indicated that persistent hepatocellular damage occurs after chronic feeding with betel quid 50,57 .…”

Section: Introductionmentioning

confidence: 99%

Habitual Betel Quid Chewing as a Risk Factor for Cirrhosis

et al. 2003

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Betel quid chewing, part of traditional Taiwanese culture, is common in 10%-20% of the human population worldwide. In this case-control study we assessed the independent and interactive role of habitual betel quid chewing and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on risk of cirrhosis. Subjects enrolled included 210 pairs of sex- and age-matched cirrhotic patients and healthy controls. Information on risk factors was obtained through serologic examination of hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C virus (anti-HCV), and a standardized personal interview with a structured questionnaire. Univariate analysis indicated that betel quid chewing, HBsAg+, anti-HCV+, alcohol drinking, and smoking are significant risk factors for cirrhosis. Multivariate analysis indicated that betel quid chewing (odds ratio [OR], 3.56), HBsAg (OR 20.37), and anti-HCV (OR 31.43) are independent risk factors for cirrhosis. Most betel quid chewers habitually drink alcohol. Although our analysis indicates that betel quid chewing acts independently from alcohol as a risk factor for cirrhosis, the confounding effect of alcohol cannot be excluded entirely by our study. There was an additive effect of the interaction between betel quid chewing and the presence of either HBsAg or anti-HCV. Moreover, a higher risk of cirrhosis was associated with longer duration of betel quid chewing and greater amount of betel quid consumed (each p for trend <0.0001). In conclusion, betel quid chewing appears to be an independent risk factor for cirrhosis. There is an additive interaction between betel quid chewing and chronic HBV/HCV infection.

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“…1 Few synthetic molecules are still under pipeline and are being probed for their utility in ALD. 4,5 Therefore, a potential candidate beneficial in ALD is still enduring. 6 The hepatoprotective activity of metformin may be due to its antioxidant effect and enhancing fatty acid oxidation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of antioxidant activity of metformin in ethanol induced liver damage in Sprague Dawley rats

Borole

Padalkar

Swami

2016

Int J Basic Clin Pharmacol

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Alcohol Consumption and Micronutrient Intake as Risk Factors for Liver Cirrhosis: A Case-Control Study

Cited by 32 publications

References 35 publications

Study of antioxidant potential of malotilate in ethanol induced hepatic dysfunction in Sprague Dawley rats

Study of antioxidant potential of malotilate in ethanol induced hepatic dysfunction in Sprague Dawley rats

Habitual Betel Quid Chewing as a Risk Factor for Cirrhosis

Assessment of antioxidant activity of metformin in ethanol induced liver damage in Sprague Dawley rats

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