Study of antioxidant potential of malotilate in ethanol induced hepatic dysfunction in Sprague Dawley rats

Assessment of antioxidant activity of metformin in ethanol induced liver damage in Sprague Dawley rats

“…7,8 Some reports suggested the role of ethanol in oxidative stress which contributes to the pathogenesis of ALD. 6 Ethanol induced oxidative stress leads to decrease fatty acid β-oxidation. This may lead to fatty liver-steatosis, hepatitis, cirrhosis.…”

“…The scoring system comprised various histological features and it suggests the extent of liver injury. 6,13 The total scores of the histopathological assessment was calculated for all groups and compared. Low HPS value was observed in metformin treated groups, whereas high HPS value was observed in ethanol treated and vehicle treated groups.…”

“…All the groups were administered ethanol 40% in the dose of 1 ml/100 gm/day to every day for 21 days by oral route. 6 Group 2 animals were administered distilled water as vehicle for Metformin orally every day for 21 days. On 22 nd day, the animals were anesthetized and blood was collected by retro-orbital puncture to assess various biochemical marker enzymes and histopathological study.…”

“…4,5 Therefore, a potential candidate beneficial in ALD is still enduring. 6 The hepatoprotective activity of metformin may be due to its antioxidant effect and enhancing fatty acid oxidation. Also it is suggested that metformin may cause down regulation of TNFα mediated signaling and activation of AMP-Kinase (AMPK).…”

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“…preventing liver damage in these models by hampering the process of liver fibrosis 2 . In our previous study malotilate was found to prevent ethanol induced liver damage 3 . Hence the objective of the present research was to assess the restorative effect of malotilate on hepatic structure and function on ethanol induced liver disease in rats.…”