Alcohol‐Associated Liver Disease: East Versus West

Charatcharoenwitthaya, Phunchai; Liangpunsakul, Suthat; Piratvisuth, Teerha

doi:10.1002/cld.920

Cited by 9 publications

(8 citation statements)

References 39 publications

(52 reference statements)

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“…In this study, a higher proportion of UK, compared with Malaysian, patients with IBS consumed regular alcohol (54.1% vs. 10.5%). This is consistent with the higher total alcohol per capita consumption among European, compared with Asian, countries 36 . Furthermore, the population of Malaysia is predominantly Muslim, and alcohol is forbidden in the religion 37 .…”

Section: Discussionsupporting

confidence: 78%

“…This is consistent with the higher total alcohol per capita consumption among European, compared with Asian, countries. 36 Furthermore, the population of Malaysia is predominantly Muslim, and alcohol is forbidden in the religion. 37 Alcohol affects gastrointestinal motility, absorption and permeability, which may contribute to more gastrointestinal symptoms.…”

Section: Discussionmentioning

confidence: 99%

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A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care

Chuah,

Black,

Tee

et al. 2023

Aliment Pharmacol Ther

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Summary Background The prevalence of irritable bowel syndrome (IBS) is now known to be similar in various geographical regions, but there has been no study directly comparing characteristics of patients with IBS between populations. Aims To evaluate clinical and psychological differences between adults with IBS seen in secondary care in the United Kingdom (UK) and Malaysia. Methods Age‐ and sex‐matched patients with IBS from a single centre in the UK (Leeds) and two centres in Malaysia (Kuala Lumpur and Kota Bharu), who fulfilled Rome III criteria, were recruited prospectively. Demographic characteristics and gastrointestinal and psychological symptoms were compared between both groups. Results A total of 266 (133 UK and 133 Malaysian) age‐ and sex‐matched patients with Rome III IBS were recruited (mean age: 45.1 years Malaysia, vs. 46.5 years UK; 57.9% female). UK patients were more likely to consume alcohol than Malaysian patients (54.1% vs. 10.5%, p < 0.001). Compared with Malaysian patients, UK patients had more frequent abdominal pain, abdominal bloating, meal‐related symptoms (p < 0.001 for all), higher symptom scores (mean 268.0 vs 166.0; p < 0.001), greater limitation of activities due to IBS (p = 0.007) and were more likely to report abnormal anxiety scores (p < 0.001). Higher perceived stress (mean 21.3 vs. 19.1, p = 0.014) and gastrointestinal symptom‐specific anxiety scores (mean 50.8 vs. 43.0, p < 0.001) were also observed in UK patients. Finally, UK patients had higher somatoform symptom‐reporting scores (mean 8.9 vs. 6.9, p < 0.001). Conclusions IBS is more severe and is associated with a higher level of psychological symptoms in the UK compared with Malaysian patients in secondary care.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care

Chuah,

Black,

Tee

et al. 2023

Aliment Pharmacol Ther

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“…The global APC is projected to increase to 7.6 litres in 2030, fuelled by increased consumption in low to middle-income countries/regions 3 , 4 . The greatest increases are anticipated in the Southeast Asia region (6.9 litres in 2030) and the Western Pacific region (9.9 litres in 2030), driven by increasing economic wealth in highly populated countries/regions such as India and China 3 , 4 , 19 – 21 . By contrast, the APC in Europe is expected to fall to 9.3 litres in 2030.…”

Section: Overview Of Global Alcohol Consumptionmentioning

confidence: 99%

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

Huang

Maury

Cortez‐Pinto

et al. 2022

Nat Rev Gastroenterol Hepatol

212

104

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Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-capita consumption rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to increase further to 7.6 litres in 2030. In 2019, an estimated 25% of global cirrhosis deaths were associated with alcohol. The global estimated age-standardized death rate (ASDR) of alcohol-associated cirrhosis was 4.5 per 100,000 population, with the highest and lowest ASDR in Africa and the Western Pacific, respectively. The annual incidence of hepatocellular carcinoma (HCC) among patients with alcohol-associated cirrhosis ranged from 0.9% to 5.6%. Alcohol was associated with approximately one-fifth of global HCC-related deaths in 2019. Between 2012 and 2017, the global estimated ASDR for alcohol-associated cirrhosis declined, but the ASDR for alcohol-associated liver cancer increased. Measures are required to curb heavy alcohol consumption to reduce the burden of alcohol-associated cirrhosis and HCC. Degree of alcohol intake, sex, older age, obesity, type 2 diabetes mellitus, gut microbial dysbiosis and genetic variants are key factors in the development of alcohol-associated cirrhosis and HCC. In this Review, we discuss the global epidemiology, projections and risk factors for alcohol-associated cirrhosis and HCC.

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“…8,84 Polymorphisms in the genes encoding members of the alcohol dehydrogenase (ADH) family are associated with an increased risk of alcohol use disorder and ALD in Asian populations, but do not correlate with risk of ALD in Caucasians. 85,86 , Patients with variants encoding for high levels of enzyme activity (ADH1B*2 and ADH1C*1 alleles) are believed to be at risk for ALD because of the accumulation of a toxic alcohol metabolite, acetaldehyde.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Emerging Biomarkers in Alcohol-associated Hepatitis

2023

Journal of Clinical and Experimental Hepatology

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Alcohol‐Associated Liver Disease: East Versus West

Cited by 9 publications

References 39 publications

A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care

A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

Emerging Biomarkers in Alcohol-associated Hepatitis

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