Alcohol and bone

Mikosch, Peter

doi:10.1007/s10354-013-0258-5

Cited by 64 publications

(63 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alcoholics showed characteristics of decreased bone synthesis, increased bone resorption and lower bone mineral density (BMD) [1, 6-8]. Animal studies also indicated decreased osteogenesis and bone volume after long-term alcohol consumption [9, 10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Protective Effect of Cordycepin On Alcohol-Induced Osteonecrosis of the Femoral Head

Chen¹,

Zhu²,

Xu³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: Alcohol abuse is known to be a leading risk factor for atraumatic osteonecrosis of the femoral head (ONFH), in which the suppression of osteogenesis plays a critical role. Cordycepin benefits bone metabolism; however, there has been no study to determine its effect on osteonecrosis. Methods: Human bone mesenchymal stem cells (hBMSCs) were identified by multi-lineage differentiation. Alkaline phosphatase (ALP) activity, RT-PCR, western blots, immunofluorescent assay and Alizarin red staining of BMSCs were evaluated. A rat model of alcohol-induced ONFH was established to investigate the protective role of cordycepin against ethanol. Hematoxylin & eosin (H&E) staining and micro-computerized tomography (micro-CT) were performed to observe ONFH. Apoptosis was assessed by TdT-mediated dUTP nick end labeling (TUNEL). Immunohistochemical staining was carried out to detect OCN and COL1. Results: Ethanol significantly suppressed ALP activity, decreased gene expression of OCN and BMP2, lowered levels of RUNX2 protein, and reduced immunofluorescence staining of OCN and COL1 and calcium formation of hBMSCs. However, these inhibitory effects were attenuated by cordycepin co-treatment at concentrations of 1 and 10 µg/mL Moreover, it was revealed that the osteo-protective effect of cordycepin was associated with modulation of the Wnt/β-catenin pathway. In vivo, by micro-CT, TUNEL and immunohistochemical staining of OCN and COL1, we found that cordycepin administration prevented alcohol-induced ONFH. Conclusion: Cordycepin treatment to enhance osteogenesis may be considered a potential therapeutic approach to prevent the development of alcohol-induced ONFH.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Other causes include steroids, trauma and hyperlipidemia [1-5]. The exact physiological mechanisms underlying alcohol-induced ONFH remain unclear.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Cordycepin On Alcohol-Induced Osteonecrosis of the Femoral Head

Chen¹,

Zhu²,

Xu³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Результаты большинства исследований указывают на увеличение под влиянием умеренных доз алкоголя мине-ральной плотности костей и снижение риска переломов, обусловленных остеопорозом [72][73][74]. Marrone et al изу-чали здоровых женщин в постменопаузе, употреблявших 19 ± 1 г этанола в день.…”

Section: остеопороз жкб деменция…unclassified

When an enemy becomes a friend. On the benefits of alcohol consumption

Буеверов¹,

Богомолов²

2018

Med. sov.

View full text Add to dashboard Cite

Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский университет) 2 Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского ВРАГ, СПОСОБНЫЙ СТАТЬ ДРУГОМ К ВОПРОСУ О ПОЛЬЗЕ АЛКОГОЛЯ В то время как высокие дозы алкоголя являются доказанным фактором риска поражения различных органов и систем, в отношении малых и умеренных доз накоплены противоположные данные. Так, регулярное употребление спиртных напит-ков в небольших количествах уменьшает вероятность развития ишемической болезни сердца, инсульта, сахарного диа-бета 2-го типа, неалкогольной жировой болезни печени, остеопороза и некоторых других заболеваний, а также снижает общую смертность. Малые дозы алкоголя подавляют активность воспаления и перекисного окисления, нормализуют гемокоагуляцию, улучшают липидный профиль, благоприятно влияют на тонус сосудистой стенки и чувствительность тка-ней к инсулину. Наиболее изучены позитивные эффекты вина, что обычно объясняется содержанием в нем полифенолов, в меньшей степени -пива; однако следует учитывать, что в большинстве проведенных исследований фигурировали раз-ные виды спиртных напитков. Таким образом, можно признать нецелесообразным полный запрет на употребление алко-голя лицам без зависимости и специфических органных поражений. Vladimirsky Moscow Regional Research Clinical Institute WHEN AN ENEMY BECOMES A FRIEND. ON THE BENEFITS OF ALCOHOL CONSUMPTIONWhile use of high doses of alcohol is a proven risk factor for various organs and systems, use of small and moderate doses bears evidence of the opposite data. Thus, regularly drinking a small amount of alcoholic drinks could reduce a person's chances of developing coronary heart disease, stroke, type 2 diabetes, non-alcoholic fatty liver disease, osteoporosis and some other diseases, and also reduce overall mortality. Small doses of alcohol suppress the inflammation and peroxidation, normalize hemocoagulation, improve the lipid profile, favourably affect blood vessel tone and the insulin-signaling pathways. Positive effects of wine are the most studied, which is usually explained by the fact that it contains polyphenols, while positive effects of beer are studied to a lesser extent; however, it should be borne in mind that the studies were aimed at different types of alcoholic beverages. Thus, it can be considered inappropriate to completely prohibit the use of alcohol to persons without dependence and specific organ damage.

show abstract

“…Mikosch [11] will present the interrelationship of alcohol and the skeletal system. Apart from the pathophysiology of bone changes induced by alcohol, clinical effects on bone, such as osteopenia/ osteoporosis including fractures and osteonecrosis will also be presented.…”

Section: Editorialmentioning

confidence: 99%