Alcohol Administration Prior to Sleep

Yules, Richard B.

doi:10.1001/archpsyc.1967.01730190096012

Cited by 76 publications

(20 citation statements)

References 5 publications

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“…Yules, Lippman and Freedman (1967) studied four young men over three or five nights of drinking with 1 g/Kg ethanol administered 4 hours before bedtime. Unfortunately, these studies predate the acceptance of a standardized sleep scoring system, and the data are difficult to interpret (e.g.…”

Section: 0 Acute Effects Of Alcohol On Sleepmentioning

confidence: 99%

Alcohol and the sleeping brain

Colrain

Nicholas

Baker

2014

Handbook of Clinical Neurology

132

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Alcohol acts as a sedative that interacts with several neurotransmitter systems important in the regulation of sleep. Acute administration of large amounts of alcohol prior to sleep leads to decreased sleep onset latency and changes in sleep architecture early in the night, when blood alcohol levels are high, with subsequent disrupted, poor quality sleep later in the night. Alcohol abuse and dependence are associated with chronic sleep disturbance, lower slow wave sleep, and more rapid eye movement sleep than normal, that last long into periods of abstinence and may play a role in relapse. The chapter outlines the evidence for acute and chronic alcohol effects on sleep architecture and sleep EEG, evidence for tolerance with repeated administration, and possible underlying neurochemical mechanisms for alcohol’s effects on sleep. Also discussed are sex differences as well as effects of alcohol on sleep homeostasis and circadian regulation. Evidence for the role of sleep disruption as a risk factor for developing alcohol dependence is discussed in the context of research conducted in adolescents. The utility of sleep evoked potentials in the assessment of the effects of alcoholism on sleep and the brain and in abstinence-mediated recovery is also outlined. The chapter concludes with a series of questions that need to be answered to determine the role of sleep and sleep disturbance in the development and maintenance of problem drinking and the potential beneficial effects of the treatment of sleep disorders for maintenance of abstinence in alcoholism.

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Section: 0 Acute Effects Of Alcohol On Sleepmentioning

confidence: 99%

Alcohol and the sleeping brain

Colrain

Nicholas

Baker

2014

Handbook of Clinical Neurology

132

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“…The effects of alcohol on the REM sleep of normal subjects werestudied by two independent investigators (18,19) who observed their patients for several baseline abstinence nights and several dose-controlled drinking nights. REM percentage decreased on the first drinking night and gradually increased to baseline levels during subsequent drinking nights.…”

Section: Rapid Eye Movement Sleep (Rem)mentioning

confidence: 99%

The Use of the Electroencephalogram in Patients Admitted for Alcohol Abuse with Seizures

Gerson¹,

Karabell²

1979

Clinical Electroencephalography

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“…First regarding ethanol effects in healthy normals, doses from 0.16 to 1.0 g/kg, yielding breath ethanol concentrations (BEC) as high as 105 mg%, have been studied (Gresham et al 1963;Yules et al, 1966;Yules et al 1967;Rundell et al 1972;Williams and Salamy 1972;Stone 1980;Prinz et al 1980;MacLean and Cairns 1982;Williams et al 1983;Roehrs et al 1991). A few studies found reduced sleep latency (Rundell et al 1972;Williams and Salamy 1972;MacLean and Cairns 1982;Williams et al 1983) and a single study found increased sleep time at the low dose, 0.16 g/kg, but no effect at 0.32 and 0.64 g/kg (Stone 1980).…”

mentioning

confidence: 99%