Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach

Wang, Han‐Tsung; Li, Yi-Hung; Chou, I-Pin; Hsieh, Ya-Hui; Chen, Bao-Ji; Chen, Ching-Yi

doi:10.1002/jsfa.5754

Cited by 16 publications

(24 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study found that BA supplementation could modulate the lipid metabolism of broiler chickens, and that BA increased endogenous cholesterol synthesis and recruited cholesterol from peripheral tissue to the liver [9]. However, there was no significant difference in serum cholesterol or LDL-C levels between the control and BA+LAB treatment groups.…”

Section: Discussionmentioning

confidence: 96%

“…There is increasing evidence that probiotics and their cell components modulate the metabolic process of the host, including lipid metabolism [26]. Our previous study on BA supplementation also indicated that the BA modulated the lipid metabolism and resulted in the lower TG levels of broiler chickens [9]. Compared to the control group, the broiler chickens fed with YC showed no effect on TG levels, suggesting that the BA supplementation effect on TG levels was not caused by the yeast host.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study also suggested that yeast with albusin B inhibits pathogenic bacteria, increases intestinal absorption of protein and glucose, and improves gut barrier function. Furthermore, it also modulated the gut microbiota by increasing cecal Lactobacillus counts and decreasing pathogenic populations [9]. Results of the effect of feeding with Lactobacillus cultures and zinc bacitracin alone, or in combination, on the growth of broiler chickens suggested that food conversion was reduced by zinc bacitracin alone but was improved by the combined use of Lactobacillus cultures and bacitracin [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of supplementation of yeast with bacteriocin and Lactobacillus culture on growth performance, cecal fermentation, microbiota composition, and blood characteristics in broiler chickens

Chen

Wang

2016

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

ObjectiveThe aim of the present study was to investigate the effect of yeast with bacteriocin and Lactobacillus cultures (mixture of Lactobacillus agilis BCRC 10436 and Lactobacillus reuteri BCRC 17476) supplements, alone or in combination, on broiler chicken performance.MethodsA total of 300, 1-d-old healthy broiler chickens were randomly divided into five treatment groups: i) basal diet (control), ii) basal diet+0.25% yeast (Saccharomyces cerevisiae) (YC), iii) basal diet+0.25% yeast with bacteriocin (BA), iv) basal diet+Lactobacillus cultures (LAB), and v) basal diet +0.25% yeast with bacteriocin+Lactobacillus cultures (BA+LAB). Growth performance, cecal microbiota, cecal fermentation products, and blood biochemistry parameters were determined when chickens were 21 and 35 d old.ResultsThe supplementation of YC, BA, and BA+LAB resulted in a significantly better feed conversion rate (FCR) than that of the control group during 1 to 21 d (p<0.05). The LAB supplementation had a significant effect on the presence of Lactobacillus in the ceca at 35 d. None of the supplements had an effect on relative numbers of L. agilis and L. reuter at 21 d, but the BA supplementation resulted in the decrease of both Lactobacillus strains at 35 d. The BA+LAB supplementation resulted in higher short chain fatty acid (SCFA) in the ceca, but LAB supplementation significantly decreased the SCFA at 35 d (p<0.05). All treatments tended to decrease ammonia concentration in the ceca at 21 d, especially in the LAB treatment group. The BA supplementation alone decreased the triacylglycerol (TG) concentration significantly at 21 d (p<0.05), but the synergistic effect of BA and LAB supplementation was required to reduce the TG concentration at 35 d. The YC supplementation tended to increase the plasma cholesterol at 21 d and 35 d. However, the BA supplementation significantly decreased the cholesterol and low density lipoprotein cholesterol level at 35 d. In conclusion, the BA+LAB supplementation was beneficial to body weight gain and FCR of broiler chickens.ConclusionThe effect of BA and LAB supplementation may be a result of the growth of lactic acid bacteria enhancement and physiological characterization of bacteriocin, and it suggests that the BA and LAB supplementation level or Lactobacillus strain selection should be integrated in future supplementation designs.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of supplementation of yeast with bacteriocin and Lactobacillus culture on growth performance, cecal fermentation, microbiota composition, and blood characteristics in broiler chickens

Chen

Wang

2016

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

show abstract

“…Creatine kinase, an enzyme catalyzing the reversible phosphorylation of creatine for cellular maintenance and energy transport [4], decreased over time in the challenged birds; it was also found to be reduced in the intestinal proteome in albusin B supplemented broilers [4]. Cytochrome b-c1, α-enolase and NADPH cytochrome p450 reductase, all enzymes in molecular pathways associated with energy metabolism, such as glycolysis, the electron transport chain and ATP synthesis all decreased in abundance over time in the challenged birds.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteriocins, a heterogeneous group of proteinaceous compounds lethal to bacteria other than the producing strain, were found to cause differential abundance of metabolic-related proteins within the jejuna, many of which were antioxidants [4]. The feeding of the probiotic Enterococcus faecium ( E. faecium ) , resulted in the differential abundance of 42 intestinal mucosal proteins, including those related to intestinal structure and immune and antioxidant systems of which 6 were abundant in the broilers fed E. faecium [5].…”

Section: Introductionmentioning

confidence: 99%

The effect of microbial challenge on the intestinal proteome of broiler chickens

et al. 2016

View full text Add to dashboard Cite

BackgroundIn poultry production intestinal health and function is paramount to achieving efficient feed utilisation and growth. Uncovering the localised molecular mechanisms that occur during the early and important periods of growth that allow birds to grow optimally is important for this species. The exposure of young chicks to used litter from older flocks, containing mixed microbial populations, is a widely utilised model in poultry research. It rarely causes mortality but effects an immunogenic stimulation sufficient enough to cause reduced and uneven growth that is reflective of a challenging growing environment.MethodsA mixed microbial challenge was delivered as used litter containing Campylobacter jejuni and coccidial oocysts to 120 male Ross 308 broiler chicks, randomly divided into two groups: control and challenged. On day 12, 15, 18 and 22 (pre- and 3, 6 and 10 days post-addition of the used litter) the proximal jejunum was recovered from 6 replicates per group and differentially abundant proteins identified between groups and over time using 2D DiGE.ResultsThe abundance of cytoskeletal proteins of the chicken small intestinal proteome, particularly actin and actin associated proteins, increased over time in both challenged and control birds. Villin-1, an actin associated anti-apoptotic protein, was reduced in abundance in the challenged birds indicating that many of the changes in cytoskeletal protein abundance in the challenged birds were as a result of an increased rate of apoptosis. A number of heat shock proteins decreased in abundance over time in the intestine and this was more pronounced in the challenged birds.ConclusionsThe small intestinal proteome sampled from 12 to 22 days of age showed considerable developmental change, comparable to other species indicating that many of the changes in protein abundance in the small intestine are conserved among vertebrates. Identifying and distinguishing the changes in proteins abundance and molecular pathways that occur as a result of normal growth from those that occur as a result of a challenging microbial environment is important in this major food producing animal.

show abstract

Albusin B, mass‐produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach

Abstract: Albusin B supplementation modulated lipid metabolism and activated systemic antioxidant defense, which might partially contribute to the performance of broiler chickens.

Cited by 16 publications

References 33 publications

Effect of supplementation of yeast with bacteriocin and Lactobacillus culture on growth performance, cecal fermentation, microbiota composition, and blood characteristics in broiler chickens

Effect of supplementation of yeast with bacteriocin and Lactobacillus culture on growth performance, cecal fermentation, microbiota composition, and blood characteristics in broiler chickens

The effect of microbial challenge on the intestinal proteome of broiler chickens

Albusin B, mass‐produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice

Contact Info

Product

Resources

About