Albusin B, mass‐produced by the <i>Saccharomyces cerevisiae</i> suppression system, enhances lipid utilisation and antioxidant capacity in mice

Hsieh, Ya-Hui; Wang, Han‐Tsung; Hsu, Jih‐Tay; Chen, Ching‐Yi

doi:10.1002/jsfa.6095

Cited by 7 publications

(9 citation statements)

References 31 publications

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“…With regard to the modulation of gut microbiota, treatment with Pum extract indirectly reduced the abundance of the genus Ruminococcus , found to be higher at baseline. The genus Ruminococcus was positively associated with a better lipid utilization in mice, via the production of the bacteriocin Albusin B, a toxin capable of enhancing lipid utilization in BALB/c mice . These data are in contrast with ours since we show that reduced plasma TG are instead associated with reduced levels of Ruminococcus .…”

Section: Discussioncontrasting

confidence: 99%

A Two‐Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob/ob Mice

Brochot

Azalbert

Landrier

et al. 2019

Molecular Nutrition Food Res

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Scope Targeting gut microbiota dysbiosis by prebiotics is effective, though side effects such as abdominal bloating and flatulence may arise following high prebiotic consumption over weeks. The aim is therefore to optimize the current protocol for prebiotic use. Methods and results To examine the prebiotic properties of plant extracts, two independent studies are conducted in ob/ob mice, over two weeks. In the first study, Porphyra umbilicalis and Melissa officinalis L. extracts are evaluated; in the second study, a high vs low dose of an Emblica officinalis Gaertn extract is assessed. These plant extracts affect gut microbiota, caecum metabolome, and induce a significant lower plasma triacylglycerols (TG) following treatment with P. umbilicalis and significantly higher plasma free fatty acids (FFA) following treatment with the low‐dose of E. officinalis Gaertn. Glucose‐ and insulin‐tolerance are not affected but white adipose tissue and liver gene expression are modified. In the first study, IL‐6 hepatic gene expression is significantly (adjusted p = 0.0015) and positively (r = 0.80) correlated with the bacterial order Clostridiales in all mice. Conclusion The data show that a two‐week treatment with plant extracts affects the dysbiotic gut microbiota and changes both caecum metabolome and markers of lipid metabolism in ob/ob mice.

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Section: Discussioncontrasting

confidence: 99%

A Two‐Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob/ob Mice

Brochot

Azalbert

Landrier

et al. 2019

Molecular Nutrition Food Res

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“…Total antioxidant capacity was analysed by the ORAC assay as described by Hsieh et al . . The assay measured fluorescence decay due to the breakdown of 2,2′‐azobis (2‐methylpropionamidine) dihydrochloride (AAPH).…”

Section: Methodsmentioning

confidence: 99%

“…Total RNA was extracted from liver using the TRI reagent (Applied Biosystem, Grand Island, NY, USA) . Two μg of total RNA was reverse transcripted with the High‐Capacity cDNA Reverse Transcription Kit (Applied Biosystem) into cDNA.…”

Section: Methodsmentioning

confidence: 99%

“…After boiling and cooling to room temperature and centrifugation, the supernate was used for triglyceride assay (Fortress). Total antioxidant capacity was analysed by the ORAC assay as described by Hsieh et al [11]. The assay measured fluorescence decay due to the breakdown of 2,2 0 -azobis (2-methylpropionamidine) dihydrochloride (AAPH).…”

Section: Triglyceride Content and Oxygen Radical Absorbance Capacity mentioning

confidence: 99%

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Development of a dietary‐induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1

Liu

Chang

et al. 2014

Eur J Clin Investigation

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“…Total antioxidant capacity was analyzed by the ORAC assay as described by Hsieh et al [13]. The assay measured fluorescence decay due to the breakdown of 2,2 0 -azobis (2-methylpropionamidine) dihydrochloride (AAPH).…”

Section: Triglyceride Content and Oxygen Radical Absorbance Capacity mentioning

confidence: 99%

The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

Liu

Chu

et al. 2017

Clinical Nutrition

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Albusin B, mass‐produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice

Abstract: This study demonstrated a beneficial effect of albusin B on lipid utilisation and anti-atherosclerotic and antioxidant capacities in mice. However, more comprehensive studies are required to elucidate the exact mechanism behind the effect of albusin B.

Cited by 7 publications

References 31 publications

A Two‐Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob/ob Mice

A Two‐Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob/ob Mice

Development of a dietary‐induced metabolic syndrome model using miniature pigs involvement of AMPK and SIRT1

The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

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