Albumin-Templated Bi₂Se₃–MnO₂ Nanocomposites with Promoted Catalase-Like Activity for Enhanced Radiotherapy of Cancer

Abstract

Novel and effective radiosensitizers that can enhance radiosensitivity of tumor tissues and increase the local radiation dose are highly desirable. In this work, templated by bovine serum albumin (BSA), Bi2Se3–MnO2 nanocomposites (Bi2Se3–MnO2@BSA) were fabricated via biomineralization, while Bi2Se3 nanodots act as radiosensitizers to increase the local radiation dosage because of their strong X-ray attenuation ability, and MnO2 with catalase-like activity can increase the oxygen concentration in tumors by triggering the decomposition of tumor endogenous H2O2 so as to improve the hypoxia-associated radioresistance of tumors. Owing to the interaction of the two components in the interface, Bi2Se3–MnO2@BSA showed promoted catalytic activity compared to MnO2@BSA, favoring tumor radiotherapy (RT) sensitization. BSA templating enabled the nanocomposites with high colloidal stability and biocompatibility as well as satisfactory tumor targeting both in vitro and in vivo; thus, an enhanced RT efficacy was obtained. Moreover, the proposed Bi2Se3–MnO2@BSA exhibited excellent performances in computerized tomography and magnetic resonance imaging. Thus, this work provides a tumor microenvironment-responsive multifunctional theranostic nanoagent with an improved performance for imaging-guided tumor RT sensitization.

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

“…79 Bi-containing semiconductors such as Bi 2 S 3 , Bi 2 Se 3 and Bi 2 O 3 have the advantages of small carrier effective masses, long Fermi wavelength, and small band overlap energy, are popular materials in the field of radiosensitization. [80][81][82][83] In addition, studies have shown that Bi is not only an excellent photothermal material, but can also be used for computed tomography (CT) as a radiosensitizer and a contrast agent. 84 Bi-based nanomaterials could utilize the high-Z element Bi to block X-rays and interact with and deplete GSH, thereby increasing X-ray deposition at tumor sites and enhancing RT.…”

“…As shown in Fig. 4, Yao et al 80 used bovine serum albumin as a template to prepare Bi 2 Se 3 –MnO 2 nanocomposites. The nanocomposites were used as radiosensitizers to increase the local radiation dose, and showed excellent performance in CT and MRI.…”

“…On the other hand, PFC loaded inside these hollow nanoparticles could be used as an oxygen carrier to moderately improve tumor oxygenation during NIR laser irradiation and further overcome the hypoxia-associated radio-resistance of tumors. As shown in Fig.4, Yao et al80 used bovine serum albumin as a template to prepare Bi 2 Se 3 -MnO 2 nanocomposites. The nanocomposites were used as radiosensitizers to increase the local radiation dose, and showed excellent performance in CT and MRI.…”

Ultrathin‐FeOOH‐Coated MnO2 Sonosensitizers with Boosted Reactive Oxygen Species Yield and Remodeled Tumor Microenvironment for Efficient Cancer Therapy

“…[ 20 ] Second, it can effectively alleviate hypoxia of TME by decomposing intracellular H 2 O 2 to O 2 , showing catalase‐like activities. [ 49 ] To verify this point, dissolved O 2 content increment in real‐time of two samples is detected in PBS solution containing 5 × 10 −4 m H 2 O 2 under US irradiation (Figure 2f ). After 200 s incubation, the dissolved O 2 content increment of MO@FHO reaches 8.5 mg L −1 , about 1.5 times of that of MO (5.7 mg L −1 ).…”

Albumin-templated manganese carbonate nanoparticles for precise magnetic resonance imaging of acute myocardial infarction

“…Herein, we provide the BSA-templated MnCO 3 nanoparticles (denoted as MnCO 3 @ BSA) through biomineralization procedure, in which BSA serves as scaffolds for nanoparticle growth and minimizes the toxicity. 23,24 After intravenous injection, the as-prepared MnCO 3 @ BSA nanoparticles preferentially accumulated into the infarcted regions of heart, therefore providing a specific contrast between the infarcted and normal areas of heart. To our knowledge, this is the first time that MnCO 3 -based nanoparticles were applied in vivo for detection of myocardial infarction by MRI.…”