Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy

Zhong, Jing; Zhang, Qin; Zhang, Zheng; Shi, Kexin; Sun, Yuanchen; Li, Teng; Lin, Jun; Yang, Kai

doi:10.1007/s12274-021-3449-1

Cited by 29 publications

(26 citation statements)

References 37 publications

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“…In another study, Zhong et al. prepared similar albumin-methotrexate nanoparticles to treat rheumatoid arthritis, but also added superoxide dismutase to combat free radicals that are characteristic of the pathology .…”

Section: Advantages Of Vesicular and Polymeric Drug Delivery Systemsmentioning

confidence: 99%

“…prepared similar albumin-methotrexate nanoparticles to treat rheumatoid arthritis, but also added superoxide dismutase to combat free radicals that are characteristic of the pathology . After 28 days, a significant reduction in joint swelling was obtained and histological studies demonstrated the absence of toxicity in other organs …”

Section: Advantages Of Vesicular and Polymeric Drug Delivery Systemsmentioning

confidence: 99%

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Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

et al. 2022

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Joint diseases are one of the most common causes of morbidity and disability worldwide. The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which require chronic treatment focused on symptomatic relief. Conventional drugs administered through systemic or intra-articular routes have low accumulation and/or retention in articular cartilage, causing dose-limiting toxicities and reduced efficacy. Therefore, there is an urgent need to develop improved strategies for drug delivery, in particular, the use of micro- and nanotechnology-based methods. Encapsulation of therapeutic agents in delivery systems reduces drug efflux from the joint and protects against rapid cellular and enzymatic clearance following intra-articular injection. Consequently, the use of drug delivery systems decreases side effects and increases therapeutic efficacy due to enhanced drug retention in the intra-articular space. Additionally, the frequency of intra-articular administration is reduced, as delivery systems enable sustained drug release. This review summarizes various advanced drug delivery systems, such as nano- and microcarriers, developed for articular cartilage diseases.

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Section: Advantages Of Vesicular and Polymeric Drug Delivery Systemsmentioning

confidence: 99%

Section: Advantages Of Vesicular and Polymeric Drug Delivery Systemsmentioning

confidence: 99%

Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

et al. 2022

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“…Since the microenvironment of RA is complex, it’s difficult for a single glucocorticoid to achieve an anti-inflammatory effect effectively. Previous studies have been devoted to the development of the combination therapy of nucleic acid drugs and chemical drugs, to improve the therapeutic effect and reduce the toxicity of chemical drugs(Li et al., 2020 ; Zhong et al., 2022 ). It’s reported that IL-10 is a major anti-inflammatory and immunosuppressive cytokine produced primarily by activated M2-type mononuclear macrophages (Fickenscher et al., 2002 ; Mosser & Zhang, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

“…Fast metabolism increases albumin demand in RA joints, which can further facilitate bionic delivery of HSA-based nanoparticles to these sites. It has been shown that the albumin-loaded drug delivery system accumulates and remains for a longer time in arthritic joints (Liu et al., 2019 ; Zhong et al., 2022 ). Inspired by this fact, it’s reasonable to engage HSA to be both a carrier and a targeting ligand developing active targeting drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy

Zheng

Wang

et al. 2022

Drug Delivery

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which is characterized by synovial inflammation and autoimmunity. The main cause of the disease is the imbalance of the proportion of pro-inflammatory macrophages (M1-type) and anti-inflammatory macrophages (M2-type) in the synovial tissues of the joint. To restore this balance, in our study, the interleukin-10 encoding anti-inflammatory cytokines (IL-10 pDNA) and chemotherapeutic drug dexamethasone sodium phosphate (DSP) were co-loaded into human serum albumin (HSA) preparing pDNA/DSP-NPs to actively target macrophages in synovium tissue to promote M1-M2 polarization. Confocal laser scanning microscope and western blot were used to demonstrate the targeting ability of co-delivery nanoparticles. In vivo , the real-time fluorescence imaging system and HPLC were used to study the tissue distribution and pharmacokinetics of nanoparticles, and the results showed that the accumulation of nanoparticles in the inflammatory joint site was higher. Its pharmacodynamics were evaluated in collagen-induced arthritis (CIA) rat model, and it demonstrated that the pDNA/DSP-NPs significantly reduced the expression of serum inflammatory factors and alleviated joint swelling and bone erosion, suggesting the favorable therapeutic effect. The synergistic treatment effect of IL-10 pDNA and DSP in this system was achieved by reducing the secretion of pro-inflammatory factors (TNF-α, IL-1β) and increasing the expression of anti-inflammatory factors (IL-10) to promote the M1-M2 polarization of macrophages. Our strategy is promising for co-delivery of gene drugs and chemical drugs by biomimetic natural materials to promote macrophages polarization so that to achieve synergically treatment of inflammatory disease.

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“…We first prepared an injectable peptide hydrogel as a depot. Then, in order to overcome the toxicity and poor solubility problem of TP, we chose human serum album (HSA), which has been proved to have a potent targeting ability to arthritic joints as a nanocarrier [ 34 – 36 ] to encapsulate and deliver TP (TP@HSA NPs). Finally, we used the hydrogel depot to load CCPA, which can relieve pain by stimulating acupuncture and TP@HSA NPs to perform nanocomposite hydrogel (TP@HSA NPs-CCPA-Gel) administrated it at ST36 to achieve prolonged and controlled release of the therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis

et al. 2021

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Background Attenuating inflammatory response and relieving pain are two therapeutic therapeutical goals for rheumatoid arthritis (RA). Anti-inflammatory and analgesic drugs are often associated with many adverse effects due to nonspecific distribution. New drug delivery systems with practical targeting ability and other complementary strategies urgently need to be explored. To achieve this goal, an acupoint drug delivery system that can target deliver anti-inflammatory drugs and simulate acupuncture in relieving pain was constructed, which can co-deliver triptolide (TP) and 2-chloro-N (6)-cyclopentyl adenosine (CCPA). Results We have successfully demonstrated that acupoint nanocomposite hydrogel composed of TP-Human serum album nanoparticles (TP@HSA NPs) and CCPA could effectively treat RA. The result shows that CCPA-Gel can enhance analgesic effects specifically at the acupoint, while the mechanical and thermal pain threshold was 4.9 and 1.6 times compared with non-acupoint, respectively, and the nanocomposite gel further enhanced. Otherwise, the combination of acupoint and nanocomposite hydrogel exerted synergetic improvement of inflammation, bone erosion, and reduction of systemic toxicity. Furthermore, it could regulate inflammatory factors and restore the balance of Th17/Treg cells, which provided a novel and effective treatment strategy for RA. Interestingly, acupoint administration could improve the accumulation of the designed nanomedicine in arthritic paws (13.5% higher than those in non-acupoint at 48 h), which may explain the better therapeutic efficiency and low toxicity. Conclusion This novel therapeutic approach-acupoint nanocomposite hydrogel, builds a bridge between acupuncture and drugs which sheds light on the combination of traditional and modern medicine. Graphical Abstract

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Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy

Cited by 29 publications

References 37 publications

Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy

Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis

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