Albumin impacts the effects of tonicity on microvascular hydraulic permeability1

Victorino, Gregory P.; Chong, Terry J.; Curran, Brian

doi:10.1016/j.jss.2004.07.019

Cited by 9 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the endothelial hyper-permeability during inflammation occurs at the post-capillary venule [18]. A multitude of mediators attenuate the endothelial hyper-permeability associated with inflammation in experimental models [9, 16, 29, 32, 35]. Unfortunately, this has not lead to a clinical treatment for endothelial hyper-permeability or repair of endothelial damage.…”

Section: Introductionmentioning

confidence: 99%

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

Dozier¹,

Cureton²,

Kwan³

et al. 2009

Peptides

Self Cite

View full text Add to dashboard Cite

Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvascular permeability induced by lipopolysaccaride (LPS), (3) involvement of the GLP-1 receptor in GLP-1 activity, and (4) involvement of the cAMP/PKA pathway in GLP-1 activity. Microvascular permeability (L(p)) of rat mesenteric post-capillary venules was measured in vivo. First, the effect of GLP-1 on basal L(p) was measured. Second, after systemic LPS injection, L(p) was measured after subsequent perfusion with GLP-1. Thirdly, L(p) was measured after LPS injection and perfusion with GLP-1+GLP-1 receptor antagonist. Lastly, L(p) was measured after LPS injection and perfusion with GLP-1+inhibitors of the cAMP/PKA pathway. Results are presented as mean area under the curve (AUC)+/-SEM. GLP-1 had no effect on L(p) (AUC: baseline=27+/-1.4, GLP-1=1+/-0.4, p=0.08). LPS increased L(p) two-fold (AUC: LPS=54+/-1.7, p<0.0001). GLP-1 reduced the LPS increase in L(p) by 75% (AUC: LPS+GLP-1=34+/-1.5, p<0.0001). GLP-1 antagonism reduced the effects of GLP-1 by 60% (AUC: LPS+GLP-1+antagonist=46+/-2.0, p<0.001). The cAMP synthesis inhibitor reduced the effects of GLP-1 by 60% (AUC: LPS+GLP-1+cAMP inhibitor=46+/-1.5, p<0.0001). The PKA inhibitor reduced the effects of GLP-1 by 100% (AUC: LPS+GLP-1+PKA inhibitor=56+/-1.5, p<0.0001). GLP-1 attenuates the increase in microvascular permeability induced by LPS. GLP-1 may protect the endothelium during inflammation, thus decreasing third-space fluid loss.

show abstract

Section: Introductionmentioning

confidence: 99%

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

Dozier¹,

Cureton²,

Kwan³

et al. 2009

Peptides

Self Cite

View full text Add to dashboard Cite

show abstract

“…Numerous biological effects of high concentration albumin have been reported including its binding capacity to other molecules [11] and attenuation of increased vascular permeability [12]. In this report, we have presented that patients had heightened vascular permeability and augmented distribution volume.…”

Section: Possible Mechanisms For At Activity Elevation After 25% Albumentioning

confidence: 65%

25% Albumin Infusion Maintains Antithrombin III (AT) Activity after AT Agent Administration in Critically Ill Patients with Disseminated Intravascular Coagulation (DIC)

Aibiki

Fukuoka²,

Shiro³

et al. 2014

J Blood Disord Transfus

View full text Add to dashboard Cite

“…Each n signifies that a single vessel was cannulated and the L p serially measured in a single rat, such that an n=3 means that 3 different vessels were studied in 3 different rats. Control studies that document the stability of this model over time and after multiple recannulations of the vessels have been previously reported [23].…”

Section: Methodsmentioning

confidence: 99%

“…The protocol was adapted from previous work [23, 24]. In brief, study microvessels were perfused with 1% Ringer/BSA solution for 10 min before baseline L p was assessed.…”

Section: Methodsmentioning

confidence: 99%

Attenuation of endothelial phosphatidylserine exposure decreases ischemia-reperfusion induced changes in microvascular permeability

Strumwasser

Bhargava

Victorino

2018

J Trauma Acute Care Surg

Self Cite

View full text Add to dashboard Cite

show abstract

Albumin impacts the effects of tonicity on microvascular hydraulic permeability1

Cited by 9 publications

References 21 publications

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

25% Albumin Infusion Maintains Antithrombin III (AT) Activity after AT Agent Administration in Critically Ill Patients with Disseminated Intravascular Coagulation (DIC)

Attenuation of endothelial phosphatidylserine exposure decreases ischemia-reperfusion induced changes in microvascular permeability

Contact Info

Product

Resources

About