Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients

Abstract

Asian Pac J Cancer Prev, 15 (15), [6449][6450][6451][6452][6453] Introduction Non-small cell lung cancer (NSCLC), which includes a broad range of lung tumors encompassing squamous cell carcinomas and adenocarcinomas as the major subtypes, is the most common cause of cancer related death (Jemal et al., 2010). In patients with lung adenocarcinoma, only a few parameters are described as a prognostic factors such as stage of disease, tumor metabolism, high GLUT1 expression and performance status (de Geus-Qei et al., 2007;Andersen et al., 2011).Serum total proteins contain albumin, globulins and other inflammatory proteins such as C-reactive protein (CRP), interleukins and tumor necrosis factors (McPherson et al., 2006). Albumin and globulins play a pivotal role in the inflammatory process . Serum albumin is also an objective parameter that reflects the degree of long-term nutrition status (Laky et al., 2007

Prognostic value of pretreatment albumin–globulin ratio in predicting long-term mortality in gastric cancer patients who underwent D2 resection

“…For instance, Du et al32 proposed that low level of AGR predicted poor survival of patients with undifferentiated nasopharyngeal carcinoma. Duran et al33 also performed a retrospective study that included 240 lung adenocarcinoma patients. They concluded that low levels of AGR remained an independent factor of mortality.…”

Pretreatment Albumin/Globulin Ratio Predicts the Prognosis for Small-Cell Lung Cancer

“…A number of studies indicated that the AGR can predict the OS of cancer patients. 23,40 In non-SCLC, Duran et al 41 and Yao et al 42 indicated that lower AGR value was significantly associated with longer OS. So, we proposed that the AGR could also be a prognostic factor for SCLC patients.…”

Preoperative albumin/globulin ratio is a potential prognosis predicting biomarker in patients with resectable gastric cancer

“…To the best of our knowledge, several previous studies have demonstrated the correlation between the preoperative AGR and long-term survival of cancers (9)(10)(11)(12)(13)(14), but GC has not been discussed. The purpose of this study was to find the cutoff value of AGR and to evaluate whether preoperative AGR has a prognostic value in patients with resectable GC.…”