Alanine/EPR dosimetry applied to the verification of a total body irradiation protocol and treatment planning dose calculation using a humanoid phantom

Schaeken, B.; Lelie, Steven; Meijnders, Paul; Weyngaert, D. Van den; Janssens, Herwig; Verellen, Dirk

doi:10.1118/1.3496355

Cited by 17 publications

(11 citation statements)

References 33 publications

(31 reference statements)

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“…Dose to water measurements D w with alanine are expressed as dose normalized amplitudes A D derived from the acquired alanine EPR absorption spectra which is explained in detail elsewhere. 10,12,14 The readings were corrected for energy, fading, and irradiation temperature. 18 The type A uncertainty component for alanine was estimated from repetitive measurements of pellets with known dose over a period of half a year: u(D w,ala ) ¼ 30 mGy.…”

Section: Iib Alanine Measurementsmentioning

confidence: 99%

“…10,11 The achievable accuracy of alanine=EPR dosimetry in the radiotherapy dose range has been discussed elsewhere 11 and the method has been used with success in dosimetric auditing 13 and in clinical practice. 14 In particular for small beam dosimetry, alanine=EPR dosimetry has been successfully used for beam profile and beam output measurements [15][16][17] and is as such recognized as a valuable independent dosimetry validation.…”

Section: Introductionmentioning

confidence: 99%

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Reference dosimetry for helical tomotherapy: Practical implementation and a multicenter validation

Ost

Schaeken²,

Vynckier

et al. 2011

Medical Physics

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Section: Iib Alanine Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reference dosimetry for helical tomotherapy: Practical implementation and a multicenter validation

Ost

Schaeken²,

Vynckier

et al. 2011

Medical Physics

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“…However, studies have been conducted to test the precision of EPR/alanine dosimetry for use in the therapeutic dose ranges [3]. The advanced radiotherapy beam modalities and applications that have been verified using alanine dosimetry include intensity modulated radiotherapy (IMRT); electron, proton, carbon ion, and neutron beams radiotherapy; tomotherapy [4]; gamma knife [5]; cyberknife [6]; brachytherapy [7]; small field dosimetry [8]; in vivo dosimetry [9]; electron arc therapy treatment planning verification [10]; total body irradiation [11]; and blood irradiation [12]. In addition, the EPR/alanine dosimetry was used in national audits of radiotherapy centers in other countries, such as the UK [13] and Italy [14].…”

Section: Introductionmentioning

confidence: 99%

Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study

Al-Karmi

Ayaz

Al-Enezi

et al. 2015

Australas Phys Eng Sci Med

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Alanine dosimeters in the form of pure alanine powder in PMMA plastic tubes were investigated for dosimetry in a clinical application. Electron paramagnetic resonance (EPR) spectroscopy was used to measure absorbed radiation doses by detection of signals from radicals generated in irradiated alanine. The measurements were performed for low-dose ranges typical for single-fraction doses often used in external photon beam radiotherapy. First, the dosimeters were irradiated in a solid water phantom to establish calibration curves in the dose range from 0.3 to 3 Gy for 6 and 18 MV X-ray beams from a clinical linear accelerator. Next, the dosimeters were placed at various locations in an anthropomorphic pelvic phantom to measure the dose delivery of a conventional four-field box technique treatment plan to the pelvis. Finally, the doses measured with alanine dosimeters were compared against the doses calculated with a commercial treatment planning system (TPS). The results showed that the alanine dosimeters have a highly sensitive dose response with good linearity and no energy dependence in the dose range and photon beams used in this work. Also, a fairly good agreement was found between the in-phantom dose measurements with alanine dosimeters and the TPS dose calculations. The mean value of the ratios of measured to calculated dose values was found to be near unity. The measured points in the in-field region passed dose-difference acceptance criterion of 3% and those in the penumbral region passed distance-to-agreement acceptance criterion of 3 mm. These findings suggest that the pure alanine powder in PMMA tube dosimeter is a suitable option for dosimetry of radiotherapy photon beams.

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“…From dosimetric perspective, a treatment planning system commissioned under standard treatment condition cannot be used directly for irradiation at an extended treatment distance. Extra scatter from the floor and the wall should be considered [7–9]. …”

Section: Introductionmentioning

confidence: 99%

Total Body Irradiation with Step Translation and Dynamic Field Matching

Chen

Chuang

et al. 2013

BioMed Research International

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The purpose of this study is to develop a total body irradiation technique that does not require additional devices or sophisticated processes to overcome the space limitation of a small treatment room. The technique aims to deliver a uniform dose to the entire body while keeping the lung dose within the tolerance level. The technique treats the patient lying on the floor anteriorly and posteriorly. For each AP/PA treatment, two complementary fields with dynamic field edges are matched over an overlapped region defined by the marks on the body surface. A compensator, a spoiler, and lung shielding blocks were used during the treatment. Moreover, electron beams were used to further boost the chest wall around the lungs. The technique was validated in a RANDO phantom using GAFCHROMIC films. Dose ratios at different body sites along the midline ranged from 0.945 to 1.076. The dose variation in the AP direction ranged from 96.0% to 104.6%. The dose distribution in the overlapped region ranged from 98.5% to 102.8%. Lateral dose profiles at abdomen and head revealed 109.8% and 111.7% high doses, respectively, at the body edges. The results confirmed that the technique is capable of delivering a uniform dose distribution to the midline of the body in a small treatment room while keeping the lung dose within the tolerance level.

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Alanine/EPR dosimetry applied to the verification of a total body irradiation protocol and treatment planning dose calculation using a humanoid phantom

Cited by 17 publications

References 33 publications

Reference dosimetry for helical tomotherapy: Practical implementation and a multicenter validation

Reference dosimetry for helical tomotherapy: Practical implementation and a multicenter validation

Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study

Total Body Irradiation with Step Translation and Dynamic Field Matching

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