Ala54Thr Polymorphism of the Fatty Acid-Binding Protein 2 Gene (Intestinal-type FABP) is Associated with Changes in Insulin Sensitivity in SGA Pubertal Girls

Mericq, Verónica; Íñiguez, Germán; Martínez, A.; Ávila, Alejandra; Mi, Hernández; Capurro, T.; Salazar, Teresa; Ángel, Bárbara; Pérez-Bravo, Francisco

doi:10.1515/jpem.2008.21.2.117

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Variation in the gene coding for FATP1 has been associated with plasma triglyceride levels in women (105). Polymorphism in the www.annualreviews.org • Fatty Acid Supply to the Human Fetus FABP-2 gene has been shown to affect the affinity of intestinal FABP for fatty acids, to alter whole-body lipid metabolism and the pattern of fat accumulation in adipose tissue, and to affect insulin resistance and its relationship to fetal growth (1,81,105,106). Polymorphism within the FABP-1 gene has also been linked to fasting triglyceride levels in females (48).…”

Section: Genetic Variationmentioning

confidence: 99%

Fatty Acid Supply to the Human Fetus

2010

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Deposition of fat in the fetus increases exponentially with gestational age, reaching its maximal rate-around 7 g/day or 90% of energy deposition-at term. In late pregnancy, many women consuming contemporary Western diets may not be able to meet the fetal demand for n-3 long chain polyunsaturated fatty acids (LCPUFAs) from the diet alone. Numerous mechanisms have evolved to protect human offspring from extreme variation or deficiency in the maternal diet during pregnancy. Maternal adipose tissue is an important source of LCPUFA. Temporal changes in placental function are synchronized with maternal metabolic and physiological changes to ensure a continuous supply of n-3 and n-6 LCPUFA-enriched fat to the fetus. LCPUFA storage in fetal adipose tissue provides an important source of LCPUFA during the critical first months of postnatal life. An appreciation of these adaptations is important in any nutritional strategy designed to improve the availability of fatty acids to the fetus.

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Section: Genetic Variationmentioning

confidence: 99%

Fatty Acid Supply to the Human Fetus

2010

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“…The physiological mechanism by which the FABP2 promoter influences BMI remains obscure. A possible pathway is the complex and still incomplete understood interaction between diabetes type 2 and obesity [27,43]. FABP2 is not solely expressed in enterocytes but also in GLP expressing intestinal epithelial L-cells [44].…”

Section: Resultsmentioning

confidence: 99%

Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study

Böhme¹,

Grallert²,

Klapper³

et al. 2009

Molecular Nutrition Food Res

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Studies in relatively small cohorts provide preliminary evidence that functional fatty acid binding protein 2 (FABP2) promoter haplotypes are associated with type 2 diabetes and BMI. Here, we studied the influence of the haplotypes on BMI by using 8072 male and female participants of the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) cohort. By linear regression analysis, we found in males a reduction of -0.39 BMI units (95% CI: -0.73, -0.05, p = 0.024) in homozygous FABP2 promoter haplotype B carriers. Carriers of haplotype B showed a significant decrease in BMI of -0.19 BMI units (95% CI: -0.35, -0.02, p = 0.027). In accordance, a significant reduction in BMI of the minor haplotype carriers in the BMI point categories of 25-30 (BMI units: -0.10, 95% CI: -0.18, -0.01, p = 0.03) and < 30 (BMI units: -0.37, 95% CI: -0.67, -0.07, p = 0.02) were found. In summary, the minor FABP2 promoter haplotype B contributes to a reduced BMI in men. This provides evidence that functional FABP2 contributes to multifactorialy regulated body weight.

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Meeting the fetal requirement for polyunsaturated fatty acids in pregnancy

Haggarty

2014

Current Opinion in Clinical Nutrition and Metabolic Care

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Large randomized controlled trials of LCPUFA supplementation in pregnancy suggest that higher n-3 LCPUFA intake reduces the risk of preterm birth and increases the length of gestation, with secondary effects on birth weight. There is little evidence of an effect on postnatal visual function and cognition, but interpretation is complicated by maternal metabolic adaptations and adipose tissue status in the newborn. The links between polymorphisms in the FADS genes and tissue fatty acid composition suggest that LCPUFA synthesis influences overall availability. Stable isotope studies have also demonstrated the capacity for LCPUFA synthesis in pregnancy, the fact that n-6 synthesis is greater than n-3, metabolic channeling of individual fatty acids to different fates, and selective placental transfer. Studies linking FADS genotype to cognition imply that n-3 LCPUFA synthesis could have an effect on infant cognition, but more large-scale genetic studies are needed.

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Ala54Thr Polymorphism of the Fatty Acid-Binding Protein 2 Gene (Intestinal-type FABP) is Associated with Changes in Insulin Sensitivity in SGA Pubertal Girls

Cited by 3 publications

References 26 publications

Fatty Acid Supply to the Human Fetus

Fatty Acid Supply to the Human Fetus

Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study

Meeting the fetal requirement for polyunsaturated fatty acids in pregnancy

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