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Kanegawa, Kazunori; Harada, Hideki; Myouga, Hisashi; Katakura, Yoshinori; Shirahata, Sanetaka; Kamei, Yuto

doi:10.1023/a:1008179302906

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…ethanol extract had the IC 50 values equal to 66.48 ± 4.96, 150.86 ± 51.56 and >400 μg/ml against MDA-MB-231, MCF-7, and T-47D cells, respectively. So far, there have only been several reports dealing with the cytotoxic effects of this algal genus,[ 32 33 34 ] and our study is the first to investigate the cytotoxic effects of this alga on breast cancer cell lines. In a research by Kanegawa et al .…”

Section: Discussionmentioning

confidence: 94%

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Cytotoxic activity of ten algae from the Persian Gulf and Oman Sea on human breast cancer cell lines; MDA-MB-231, MCF-7, and T-47D

Erfani¹,

Nazemosadat²,

Moein

2015

Phcog Res

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Background:Seaweeds have proven to be a promising natural source of bioactive metabolites for drug development.Objective:This study aimed to monitor the ethanol extract of ten algae from the Persian Gulf and Oman Sea, for their in vitro cytotoxic activity on three human breast cancer cell lines.Materials and Methods:Three human breast cancer cell lines including MDA-MB-231(ER−), MCF-7(ER+), and T-47D (ER+) were treated by different concentrations of total ethanol (90%) algae extracts and the cytotoxic effects were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Doxorubicin (Ebewe, Austria) was used as a positive control. After 72 h of incubation, the cytotoxic effect of the algae was calculated and presented as 50%-inhibitory concentration (IC50).Results:The results indicated Gracilaria foliifera and Cladophoropsis sp. to be the most active algae in terms of cytotoxic effects on the investigated cancer cell lines. The IC50 values against MDA-MB-231, MCF-7, and T-47D cells were, respectively, 74.89 ± 21.71, 207.81 ± 12.07, and 203.25 ± 30.98 µg/ml for G. foliifera and 66.48 ± 4.96, 150.86 ± 51.56 and >400 µg/ml for Cladophoropsis sp. The rest of the algal extracts were observed not to have significant cytotoxic effects in the concentration range from 6.25 µg/ml to 400 µg/ml.Conclusion:Our data conclusively suggest that G. foliifera and Cladophoropsis sp. may be good candidates for further fractionation to obtain novel anticancer substances. Moreover, stronger cytotoxic effects on estrogen negative breast cancer cell line (MDA-MB-231(ER−)) in comparison to estrogen positive cells (MCF-7 and T-47D) suggest that the extract of G. foliifera and Cladophoropsis sp. may have an estrogen receptor/progesterone receptor-independent mechanism for their cellular growth inhibition.

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Section: Discussionmentioning

confidence: 94%

“…C. zollingeri extract was observed to have moderate telomerase inhibitory effect on MOLT-4 leukemic cell line. [ 34 ] Studies done by Harada et al . on 306 marine algae revealed that the methanol extract of C. vaucheriaeformis with the concentrations of 50–100 μg/ml has a high cytocidal effect on L1210 murine leukemic cells.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic activity of ten algae from the Persian Gulf and Oman Sea on human breast cancer cell lines; MDA-MB-231, MCF-7, and T-47D

Erfani¹,

Nazemosadat²,

Moein

2015

Phcog Res

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“…Following up reports on the inhibitory activity of CYN ( 1 ) on microtubule protein polymerization, first synthetic CYN analogues in form of colchicine hybrids were generated, however with limited activity 3. CYN ( 1 ) itself is also active as inhibitor of telomerase,4 amylase,5 xanthine oxidase6 and plant lipoxygenases (LOs) 7. We reported that CYN ( 1 ) inhibits soybean LO with an IC 50 value of 5.1 μ M in an uncompetitive manner 7b.…”

Section: Methodsmentioning

confidence: 99%

Photoredox Catalysis of Intramolecular Cyclizations with a Reusable Silica‐Bound Ruthenium Complex

et al. 2015

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Photoredox catalysis with the use of a stable, reusable silica‐bound chromophore was applied to the intramolecular cyclization of a series of 2‐benzylidenehydrazinecarbothioamides to give 5‐phenyl‐1,3,4‐thiadiazol‐2‐amines. The catalyst was readily prepared by carbodiimide‐mediated coupling of commercially available amine‐functionalized silica beads to a carboxylic acid functionalized ruthenium complex. The immobilized catalyst was readily removed from the reaction product by filtration and was used eight times without loss of catalytic activity. This simple, safe, and practical method is an attractive alternative to conventional procedures.

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Caulerpenyne and Related Bis‐enol Esters Are Novel‐Type Inhibitors of Human 5‐Lipoxygenase

et al. 2014

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Caulerpenyne (CYN) is a sesquiterpene from green algae with known inhibitory properties against soybean lipoxygenase. Here we introduce a detailed structure-activity study elucidating the inhibitory effects of CYN and a library of six synthetic CYN analogues on isolated human 5-lipoxygenase (5-LO) and cellular 5-LO in polymorphonuclear leukocytes. Essential structural elements are identified and a structurally simplified inhibitor is introduced. The modes of 5-LO inhibition by CYN and the synthetic inhibitors cannot be assigned to any of the known categories of lipoxygenase inhibitors. These compounds clearly interfere directly with 5-LO and represent rather small and flexible molecules, with unique structures among 5-LO inhibitors identified thus far.

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Cited by 14 publications

References 28 publications

Cytotoxic activity of ten algae from the Persian Gulf and Oman Sea on human breast cancer cell lines; MDA-MB-231, MCF-7, and T-47D

Cytotoxic activity of ten algae from the Persian Gulf and Oman Sea on human breast cancer cell lines; MDA-MB-231, MCF-7, and T-47D

Photoredox Catalysis of Intramolecular Cyclizations with a Reusable Silica‐Bound Ruthenium Complex

Caulerpenyne and Related Bis‐enol Esters Are Novel‐Type Inhibitors of Human 5‐Lipoxygenase

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