Al-Qaeda 2.0

Holbrook, Donald; Moore, Cerwyn

doi:10.1093/oso/9780190856441.001.0001

Cited by 6 publications

(4 citation statements)

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“…Five human 5-HT 3 receptor subunits have been cloned and homo-oligomeric assemblies of 5-HT 3 A and hetero-oligomeric assemblies of 5-HT 3 A and 5-HT 3 B subunits have been characterised in detail. The 5-HT 3 C (HTR3C, Q8WXA8), 5-HT 3 D (HTR3D, Q70Z44) and 5-HT 3 E (HTR3E, A5X5Y0) subunits [506,764], like the 5-HT 3 B subunit, do not form functional homomers, but are reported to assemble with the 5-HT 3 A subunit to influence its functional expression rather than pharmacological profile [419,766,1115]. 5-HT 3 A, -C, -D, and -E subunits also interact with the chaperone RIC-3 which predominantly enhances the surface expression of homomeric 5-HT 3 A receptor [1115].…”

Section: -Ht 3 Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: -Ht 3 Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

View full text Add to dashboard Cite

show abstract

“…These stipulated avoiding killing and harming civilians, the targeting of mosques and markets, and avoiding confrontation with Christians, Sikhs and Hindus in Islamic countries. 172 Amadou Koufa has continued this policy. Although Katiba Macina's initial expansion was predicated on killing local leaders and intimidating the population, Koufa has been careful in his choice of targets, predominantly focusing on Malian security forces, and French and international troops.…”

Section: Defeat and Elimination By Brute Force (Repression)mentioning

confidence: 99%

Pathways out of the Quagmire ? Perspectives for al-Quaeda in the Sahel

Boeke¹

2021

ICCT Journal

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This article focuses on counter-terrorism efforts against al-Qaeda in the Islamic Maghreb (AQIM) and the Group for the Support of Islam and Muslims (JNIM), its main confederation of combat units. Using literature on how terrorist groups end, the article analyses perspectives for AQIM and JNIM. It describes the conceptual distinction between insurgency and terrorism, and structures insights along six pathways of decline, namely reorientation, repression, decapitation, negotiation, failure or success. JNIM is currently fighting a large-scale insurgency in Mali, Niger and Burkina Faso, while policy responses remain grounded in the paradigm of counter-terrorism, not counter- insurgency. The search and destroy missions of recently terminated Operation Barkhane did not manage to secure areas, and tactical successes were offset by targeting errors and exactions, fuelling jihadist recruitment. Leadership decapitation – also a focus of future French counter- terrorist efforts - has proved ineffective. The option of negotiations merits further exploration, but France and the Sahelian countries diverge in their approaches. Bottom-up ceasefires have improved local security in some areas, but risk benefiting AQIM in the long term. Finally, violent conflict between AQIM and the Islamic State in the Greater Sahara (ISGS) has hurt both groups, and their vulnerabilities to internal strife and the loss of public support could be leveraged more in counter-terrorism efforts.

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“…Five human 5-HT 3 receptor subunits have been cloned and homo-oligomeric assemblies of 5-HT 3 A and hetero-oligomeric assemblies of 5-HT 3 A and 5-HT 3 B subunits have been characterised in detail. The 5-HT 3 C (HTR3C, Q8WXA8), 5-HT 3 D (HTR3D, Q70Z44) and 5-HT 3 E (HTR3E, A5X5Y0) subunits [470,705], like the 5-HT 3 B subunit, do not form functional homomers, but are reported to assemble with the 5-HT 3 A subunit to influence its functional expression rather than pharmacological profile [391,707,1041]. 5-HT 3 A, -C, -D, and -E subunits also interact with the chaperone RIC-3 which predominantly enhances the surface expression of homomeric 5-HT 3 A receptor [1041].…”

Section: Overviewmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander

Mathie

Peters

et al. 2019

British J Pharmacology

294

248

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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14749. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Al-Qaeda 2.0

Cited by 6 publications

References 0 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Pathways out of the Quagmire ? Perspectives for al-Quaeda in the Sahel

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

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