Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer

Gu, Zhenyang; Pei, Wenlong; Zhang, Yi; Zhu, Jun; Li, Lei; Zhang, Zhan

doi:10.1097/cm9.0000000000001829

Cited by 20 publications

(14 citation statements)

References 17 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…calcoaceticus, and Ak. muciniphila were higher, whereas Bacteroidetes, Rikenellaceae, Ruminococcaceae, C. cluster XIVa, and Flavovobacterium showed low abundance [134][135][136][137][138][139][140][141][142][143][144] (Fig. 4).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

The role of gut microbiota in T cell immunity and immune mediated disorders

Shim¹,

Ryu²,

Jo³

et al. 2023

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug.

show abstract

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

The role of gut microbiota in T cell immunity and immune mediated disorders

Shim¹,

Ryu²,

Jo³

et al. 2023

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…It also reversed the high fat-induced pro-in ammatory cytokine IL-6 and visceral adipose tissue in ammation through Treg induction [53]. In in ammatory bowel diseases, A. muciniphila showed decreased abundance and is a potential target for dietary and/or pharmaceutical interventions [54]. The abundance of Parasutterella showed a positive correlation with the in ammatory cells in subcutaneous tissue during IBS development and progression in patients [55].…”

Section: Discussionmentioning

confidence: 98%

Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model

Gao

Yan

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Chinese medicines (CMs) have emerged as an alternative therapy for ulcerative colitis through reinforcing the vital qi and/or eliminating the pathogenic factors according to the traditional Chinese medicinal theory. Presystemic interactions of CMs with gut microbiota and the associated host metabolic network shift are believed to be essential to achieve their holistic health benefits in traditional oral application. Methods: This study first employed 16S rDNA-based microbial profiling and mass spectrometry-based urinary metabolomics to simultaneously evaluate single CMs frequently prescribed as main constituent herbs for alleviating UC, the tonic ginseng and Astragali Radix (AR) and the detoxifying Scutellaria Radix (SR) and Rhubarb, on a dextran sodium sulfate (DSS)-induced colitis rat model, with aims to understanding the tonifying or detoxifying properties of CMs through clinical phenotypes, the common features and herb-specific signatures in gut microbial alterations and the associated host metabolic shifts. Colitis was induced in rats receiving 5% DSS for consecutive 7 days. Control group received water alone. Herbal groups received 5% DSS and respective herbal preparation by gavage once daily. Body weight, stool consistency, and rectal bleeding were recorded daily. Feces and urine were freshly collected at multiple time points. On day 7, blood and colon tissues were collected to determine anti-/pro-inflammatory cytokines levels, colonic myeloperoxidase activity, and histopathologic alterations. Results: Gut microbiome was more prone to herb intervention than metabolome and displayed increasing associations with metabolic dynamics. Although both the tonic and the detoxifying herbs alleviated colitis and caused some similar changes in DSS-induced microbiome and metabolome disturbance, the tonic herbs were more effective and shared more common microbial and metabolic signatures. The detoxifying herbs elicited herb-specific changes. Rhubarb uniquely affected phenylalanine metabolism and established high correlations between Akkermansia muciniphila and Parasutterella and hydroxyphenylacetylglycine and phenylbutyrylglycine, while SR caused significant elevation of steroidal glucuronides dehydropregnenolone glucuronide and estriol glucuronide, both displaying exclusive correlations with genus Acetatifactor. Conclusions: Both tonic and detoxifying herbs tested ameliorated experimental colitis and elicited alternative microbial and host metabolic reprogramming. The findings highlight the importance of presystemic interactions with gut microbiota to host metabolic shifts and promote modern translation of tonifying and detoxifying properties of CMs.

show abstract

“…Upregulation of Akkermansia by metformin improved glucose homeostasis in diet-induced obesity in mice [ 60 ]. Additionally, the abundance of these bacteria is inversely associated with inflammatory diseases of the gut, such as IBD and Crohn’s disease [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Khalili

Centner

Salazar

2023

IJMS

View full text Add to dashboard Cite

Atherosclerosis is a major cause of death and disability. The beneficial effects of phytochemicals and probiotics on atherosclerosis have gained significant interest since these functional foods can improve inflammation, oxidative stress, and microbiome dysbiosis. The direct effect of the microbiome in atherosclerosis, however, needs further elucidation. The objective of this work was to investigate the effects of polyphenols, alkaloids, and probiotics on atherosclerosis using a meta-analysis of studies with mouse models of atherosclerosis. Identification of eligible studies was conducted through searches on PubMed, Embase, Web of Science, and Science Direct until November 2022. The results showed that phytochemicals reduced atherosclerosis, which was significant in male mice, but not in females. Probiotics, on the other hand, showed significant reductions in plaque in both sexes. Berries and phytochemicals modulated gut microbial composition by reducing the Firmicutes/Bacteroidetes (F/B) ratio and by upregulating health-promoting bacteria, including Akkermansia muciniphila. This analysis suggests that phytochemicals and probiotics can reduce atherosclerosis in animal models, with a potentially greater effect on male animals. Thus, consumption of functional foods rich in phytochemicals as well as probiotics are viable interventions to improve gut health and reduce plaque burden in patients suffering from cardiovascular disease (CVD).

show abstract

Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer

Cited by 20 publications

References 17 publications

The role of gut microbiota in T cell immunity and immune mediated disorders

The role of gut microbiota in T cell immunity and immune mediated disorders

Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model

Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Contact Info

Product

Resources

About