Akinetic Mutism Following Unilateral Anterior Cerebral Artery Occlusion

Anderson, Charles A.; Arciniegas, David B.; Huddle, Daniel C.; Leehey, Maureen A.

doi:10.1176/jnp.15.3.385

Cited by 17 publications

(5 citation statements)

References 4 publications

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“…It is a severe clinical condition in which the person is totally deprived of motivation, devoid of primary needs, and characterized by a severe reduction of motricity, facial expressions, gestures, and verbal communication. However, these persons still retain some degree of alertness (16,17).…”

Section: Motivational Disorders In Acquired Brain Injury Survivorsmentioning

confidence: 99%

Neurobehavioral Initiation and Motivation Problems After Acquired Brain Injury

2020

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Motivation is a primary and permanent source of human behavior and adaptation. Motivational deficits, along with deficiencies in initiation, frequently occur in individuals with acquired brain injury (ABI). These neurobehavioral problems are associated with consequences at the participation level: patients are reluctant to engage in rehabilitation, and their subsequent social reintegration is often at risk. The same problems may also become a heavy burden for the families of individuals with ABI. In the present paper, we will critically review both the current definitions and the instruments used to measure motivational disorders following ABI. We will also describe the neural system underlying motivation and its impairments. What emerges is the need to develop specific rehabilitative treatments, still absent at the moment, with the ultimate aim of ensuring a better quality of life for both the patients and their proxies.

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Section: Motivational Disorders In Acquired Brain Injury Survivorsmentioning

confidence: 99%

Neurobehavioral Initiation and Motivation Problems After Acquired Brain Injury

2020

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“…Verbal output is absent and the patients cannot follow commands. The most pronounced cases follow bilateral AC lesions (Oberndorfer et al, 2002;Tengvar et al, 2004), while unilateral lesions tend to result in transient forms of the syndrome (Anderson et al, 2003;Oomman and Madhusudhanan, 1999). Lesions to subcortical components of the circuit (globus pallidus, dorsomedial thalami), internal capsule and the adjacent structures (e.g.…”

Section: Human Lesion and Neurodegenerative Studiesmentioning

confidence: 99%

Neurobiological basis of motivational deficits in psychopathology

Salamone

Koychev

Correa

et al. 2015

European Neuropsychopharmacology

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“… 81 Unilateral lesions of the anterior cingulate cortex tend to produce transient akinetic mutism. 82 , 83 The term “abulia,” derived from the Greek boul, or “will,” 77 refers to a similar but less severe psychomotor syndrome, encompassing lack of spontaneity, apathy, and paucity of speech and movement.…”

Section: The Anterior Cingulate Circuitmentioning

confidence: 99%

Frontal-subcortical circuitry and behavior

Bonelli

Cummings

2007

Dialogues in Clinical Neuroscience

514

154

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The neuropsychiatric manifestations of neurodegenerative diseases are closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, are effector mechanisms that allow the organism to act on its environment. In this paper, we present the three main frontal-subcortical circuits: the dorsolateral prefrontal circuit allows the organization of information to facilitate a response; the anterior cingulate circuit is required for motivated behavior; and the orbitofrontal circuit allows the integration of limbic and emotional information into behavioral responses. Impaired executive functions, apathy, and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. A variety of other neuropsychiatric disorders, such as Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, schizophrenia, and mood disorders may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.

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Akinetic Mutism Following Unilateral Anterior Cerebral Artery Occlusion

Cited by 17 publications

References 4 publications

Neurobehavioral Initiation and Motivation Problems After Acquired Brain Injury

Neurobehavioral Initiation and Motivation Problems After Acquired Brain Injury

Neurobiological basis of motivational deficits in psychopathology

Frontal-subcortical circuitry and behavior

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