Aislamiento de Pandoraea pulmonicola en paciente con fibrosis quística

Ayala-Balzola, Ana Pérez de; Buendía-Moreno, Buenaventura; Girón-Moreno, Rosa María; López-Brea, M

doi:10.1157/13091792

Cited by 2 publications

(1 citation statement)

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“…In humans, Pandoraea spp. are mainly isolated from Cystic Fibrosis (CF) patients, and may cause chronic lung colonization [ 7 – 9 ]. Several Pandoraea species have been reported in CF patients.…”

Section: Introductionmentioning

confidence: 99%

Epidemic spread of Pandoraea pulmonicola in a cystic fibrosis center

et al. 2015

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BackgroundPandoraea spp. are recently discovered bacteria, mainly recovered from cystic fibrosis (CF) patients, but their epidemiology and clinical significance are not well known. We describe an epidemic spread of Pandoraea pulmonicola from 2009 in our CF center, involving 6 out of 243 CF patients.MethodsBacterial identification used amplified ribosomal DNA restriction analysis (ARDRA), MALDI-TOF mass spectrometry (MALDI-TOF MS) and 16S rDNA gene sequencing. The clonal link between strains was assessed with pulsed field gel electrophoresis (PFGE) using XbaI. Clinical data were gathered for all patients.ResultsThe index case was chronically colonized since 2000. The main hypothesis for this bacterial spread was a droplet cross-transmission, due to preventive measures not being strictly followed. Antibiotic susceptibility testing revealed resistance to beta-lactams, ciprofloxacin and colistin. However, there was susceptibility to trimethoprim-sulfamethoxazole. All patients were chronically colonized with Pseudomonas aeruginosa, and the acquisition of P. pulmonicola resulted in chronic colonization in all patients. Three patients died, and two patients remained clinically stable, whereas one patient had a decline in lung function.ConclusionsThis study, which is the first to describe an epidemic spread of P. pulmonicola, notes the potential transmissibility of this bacterial species and the need for infection control measures.

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Section: Introductionmentioning

confidence: 99%

Epidemic spread of Pandoraea pulmonicola in a cystic fibrosis center

et al. 2015

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Pandoraea pulmonicola chronic colonization in a cystic fibrosis patient, France

Kokcha

Bittar

Reynaud-Gaubert

et al. 2013

New Microbes and New Infections

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Pandoraea are considered emerging multidrug resistant pathogens in the context of cystic fibrosis. We report herein for the first time the case of a 30-year-old woman with cystic fibrosis, living in France, who was chronically infected with Pandoraea pulmonicola and who died of Pseudomonas aeruginosa sepsis 3 weeks after bilateral lung transplantation.

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Aislamiento de Pandoraea pulmonicola en paciente con fibrosis quística

Cited by 2 publications

References 11 publications

Epidemic spread of Pandoraea pulmonicola in a cystic fibrosis center

Epidemic spread of Pandoraea pulmonicola in a cystic fibrosis center

Pandoraea pulmonicola chronic colonization in a cystic fibrosis patient, France

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